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Mitomycin

Generic Name: mitomycin (mye-toe-MYE-sin)
Brand Name: Mutamycin

Mitomycin may cause bone marrow suppression, which may cause severe blood problems such as low platelet levels (thrombocytopenia) and low white blood cell levels (leukopenia). These blood problems may increase your risk of developing severe bleeding or a severe and possibly fatal infection. Mitomycin may also increase your risk of developing hemolytic uremic syndrome (HUS), which may cause problems such as hemolytic anemia, low platelet count, and permanent kidney failure. HUS may occur at any time during treatment. Higher doses may increase your risk for developing this side effect. Blood transfusions may make the symptoms of this syndrome worse. Notify your doctor immediately if you develop symptoms of an infection (eg, fever, chills, persistent sore throat), fatigue, unusual bleeding or bruising, or a change in the amount of urine produced.


Mitomycin is used for:

Treating cancer of the stomach or pancreas in combination with other medicines. It may also be used to reduce the severity of these cancers when they have not responded to other treatments. It may also be used for other conditions as determined by your doctor.

Mitomycin is an antibiotic that has been shown to have action against tumors. It works by blocking growth of the cancer cell.

Do NOT use mitomycin if:

  • you are allergic to or have had an unusual reaction to any ingredient in mitomycin
  • you have low blood platelet levels (thrombocytopenia), low white blood cell levels (leukopenia), blood clotting problems, or bleeding problems
  • you have active severe bleeding
  • you have shingles or chickenpox

Contact your doctor or health care provider right away if any of these apply to you.

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Before using mitomycin:

Some medical conditions may interact with mitomycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems, breathing problems, or bone marrow problems

Some MEDICINES MAY INTERACT with mitomycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Vinca alkaloids (eg, vincristine) or other cancer medicines because lung problems, such as severe shortness of breath, may occur
  • Tamoxifen because risk of anemia, low blood platelet levels, or hemolytic uremic syndrome may be increased
  • Doxorubicin because risk of heart failure may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if mitomycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use mitomycin:

Use mitomycin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Mitomycin is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using mitomycin at home, carefully follow the injection procedures taught to you by your health care provider.
  • If nausea, vomiting, or loss of appetite occur, ask your doctor or pharmacist for ways to lessen these effects.
  • Mitomycin may cause a serious reaction if it comes in contact with your skin. If this happens, wash the area with soap and water for approximately 15 minutes. Contact your doctor as soon as possible. The use of gloves while handling mitomycin is recommended.
  • If mitomycin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of mitomycin, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use mitomycin.

Important safety information:

  • Mitomycin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Mitomycin may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
  • Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking mitomycin. Talk to your doctor before having any vaccinations while you are using mitomycin.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using mitomycin.
  • LAB TESTS, including platelet count, complete blood cell count, and kidney function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use mitomycin with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if mitomycin can cause harm to the fetus. If you become pregnant while taking mitomycin, discuss with your doctor the benefits and risks of using mitomycin during pregnancy. It is unknown if mitomycin is excreted in breast milk. Do not breast-feed while taking mitomycin.

Possible side effects of mitomycin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Hair loss; loss of appetite; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; decreased urination; dizziness; dry cough; fever, chills, or sore throat; pain, redness, or swelling at the injection site; shortness of breath; sores or swelling of the mouth, lips, hands, or feet; unusual bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of mitomycin:

Mitomycin is usually handled and stored by a health care provider. If you are using mitomycin at home, store mitomycin as directed by your pharmacist or health care provider.

General information:

  • If you have any questions about mitomycin, please talk with your doctor, pharmacist, or other health care provider.
  • Mitomycin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take mitomycin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mitomycin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mitomycin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using mitomycin.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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