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Lodosyn

Generic Name: carbidopa (KAR-bi-DOE-pa)
Brand Name: Lodosyn

Lodosyn is used for:

Treating symptoms associated with Parkinson disease and parkinsonism-like symptoms caused by other conditions. It is used in combination with another medicine called levodopa. It may also be used for other conditions as determined by your doctor.

Lodosyn is an antiparkinson agent. It works by helping levodopa to reach the brain.

Do NOT use Lodosyn if:

  • you are allergic to any ingredient in Lodosyn
  • you have narrow-angle glaucoma
  • you have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Lodosyn:

Some medical conditions may interact with Lodosyn. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have undiagnosed skin growths, skin cancer, or a history of skin cancer
  • if you have an irregular heartbeat, heart disease, ulcer, seizures, blood pressure problems, asthma, lung problems, liver or kidney problems, blood or hormone problems, sleep problems, stomach or intestinal bleeding, glaucoma, or a history of heart attack, mental or mood problems, or suicidal thoughts or attempts

Some MEDICINES MAY INTERACT with Lodosyn. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • MAOIs (eg, phenelzine) because the risk of severe high blood pressure may be increased
  • Tricyclic antidepressants (eg, amitriptyline) because the risk of high blood pressure or unusual muscle movements may be increased
  • Blood pressure medicines or selegiline because the risk of severe dizziness on standing may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lodosyn may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lodosyn:

Use Lodosyn as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Lodosyn by mouth with or without food.
  • Diets that are high in protein may decrease your body's ability to absorb Lodosyn. Discuss any questions or concerns with your doctor. Tell your doctor if you have a diet that is high in protein, or if you will be changing your diet to include more protein.
  • Carefully follow the dosing schedule given to you by your health care provider. It may take several weeks to a few months to notice benefit from use because the dose is carefully adjusted over time.
  • If you are also taking iron salts (eg, ferrous sulfate), do not take them within 2 hours before or 2 hours after taking Lodosyn. Check with your doctor if you have questions.
  • Take Lodosyn on a regular schedule to get the most benefit from it. Taking Lodosyn at the same times each day will help you to remember to take it.
  • Continue to take Lodosyn even if you feel well. Do not miss any doses.
  • If you have been taking levodopa alone, do not start taking Lodosyn until at least 12 hours after your final dose of levodopa.
  • If you miss a dose of Lodosyn, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lodosyn.

Important safety information:

  • Lodosyn may cause drowsiness, dizziness, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Lodosyn with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Lodosyn; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Lodosyn may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Some patients who take Lodosyn have reported suddenly falling asleep while performing daily activities (eg, driving, eating, talking). Some patients did not experience drowsiness and felt that they were alert immediately before suddenly falling asleep. Some of these events have been reported as late as 1 year after Lodosyn was started. Use caution when driving, operating machinery, or performing other activities that could be dangerous. Inform your doctor if you experience unusual drowsiness or sleepiness while using Lodosyn.
  • Tell your doctor or dentist that you take Lodosyn before you receive any medical or dental care, emergency care, or surgery.
  • You may experience an increase in involuntary movements while taking Lodosyn. Check with your doctor if this occurs.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Lodosyn. Symptoms may include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your doctor at once if you have any of these symptoms.
  • Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Lodosyn. Tell your doctor right away if you notice such effects.
  • Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Lodosyn also increases the risk of melanoma. You may need to have skin exams while you are using Lodosyn. Discuss any questions or concerns with your doctor.
  • Diabetes patients - Lodosyn may cause the results of some tests for urine glucose or urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Do not change your dose or suddenly stop taking Lodosyn. Side effects may occur. They may include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Your dose may need to be slowly lowered by your doctor to avoid side effects.
  • Gradually increase physical activity as your symptoms improve.
  • A dark color (red, brown, or black) may appear in your saliva, urine, or sweat after taking Lodosyn. This is not harmful.
  • The effects of Lodosyn might start to wear off between doses. Talk with your doctor if Lodosyn stops working well or if your condition worsens.
  • Lodosyn may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Lodosyn
  • LAB TESTS, including complete blood cell counts and heart, kidney, and liver function tests, may be performed while you use Lodosyn. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Lodosyn with caution in ELDERLY patients; they may be more sensitive to its effects.
  • Lodosyn should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lodosyn while you are pregnant. It is not known if Lodosyn is found in breast milk. If you are or will be breast-feeding while you use Lodosyn, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Lodosyn:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); black, tarry stools; burning, numbness, or tingling; chest pain; confusion; depression; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; increased sweating; mental or mood changes; muscle pain or unusual stiffness; severe light-headedness or fainting; severe or persistent stomach pain, nausea, or vomiting; suicidal thoughts or actions; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; unusual skin growths or change in the appearance or size of a mole; vision changes (blurred/double vision); vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Lodosyn:

Store Lodosyn at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lodosyn out of the reach of children and away from pets.

General information:

  • If you have any questions about Lodosyn, please talk with your doctor, pharmacist, or other health care provider.
  • Lodosyn is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Lodosyn or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Lodosyn. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Lodosyn. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Lodosyn.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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