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Imiglucerase

Generic Name: imiglucerase (eye-mih-GLOO-ser-ace)
Brand Name: Cerezyme

Imiglucerase is used for:

Treatment of type I Gaucher disease that has caused anemia (eg, low red blood cell count), thrombocytopenia (low platelet count), bone disease, or enlargement of the liver or spleen.

Imiglucerase is an enzyme. It works by supplementing a deficiency of an enzyme that is found naturally in the body. Without the enzyme, substances accumulate in the liver, spleen, bone marrow, and sometimes the lung, kidney, and intestine, causing complications, such as anemia and thrombocytopenia.

Do NOT use imiglucerase if:

  • you are allergic to any ingredient in imiglucerase

Contact your doctor or health care provider right away if any of these apply to you.

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Before using imiglucerase:

Some medical conditions may interact with imiglucerase. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with imiglucerase. However, no specific interactions with imiglucerase are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if imiglucerase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use imiglucerase:

Use imiglucerase as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Imiglucerase is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using imiglucerase at home, carefully follow the injection procedures taught to you by your health care provider.
  • Gently swirl imiglucerase when mixing. Do not shake.
  • If imiglucerase contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • After using imiglucerase, discard any open vials.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of imiglucerase, contact your doctor for advice on when to schedule the next dose.

Ask your health care provider any questions you may have about how to use imiglucerase.

Important safety information:

  • Imiglucerase may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to imiglucerase. Using imiglucerase alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Several months may pass before imiglucerase reaches its full effect. Continue to use imiglucerase during this time.
  • Limit alcohol intake while using imiglucerase.
  • LAB TESTS, including immunoglobulin G antibody levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using imiglucerase during pregnancy. It is unknown if imiglucerase is excreted in breast milk. If you are or will be breast-feeding while you are using imiglucerase, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of imiglucerase:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Backache; chills; diarrhea; dizziness; fever; general body discomfort; headache; nausea; rash; stomach pain; swelling of the legs and feet; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bluish skin discoloration; fast heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of imiglucerase:

Imiglucerase is usually handled and stored by a health care provider. If you are using imiglucerase at home, store imiglucerase as directed by your pharmacist or health care provider. Keep imiglucerase out of the reach of children and away from pets.

General information:

  • If you have any questions about imiglucerase, please talk with your doctor, pharmacist, or other health care provider.
  • Imiglucerase is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take imiglucerase or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about imiglucerase. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to imiglucerase. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using imiglucerase.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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