Imiglucerase Side Effects

Brand Names: Cerezyme

Please note - some side effects for Imiglucerase may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Imiglucerase - for the Consumer

Imiglucerase

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Imiglucerase:

Backache; chills; diarrhea; dizziness; fever; general body discomfort; headache; nausea; rash; stomach pain; swelling of the legs and feet; tiredness; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bluish skin discoloration; fast heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Hypersensitivity

Hypersensitivity side effects including symptoms suggestive of hypersensitivity have been noted in approximately 6.6% of patients. Anaphylactoid reaction has also been reported.

Onset of hypersensitivity symptoms has occurred during or shortly after infusions. These symptoms include pruritus, flushing, urticaria, angioedema, chest discomfort, dyspnea, coughing, cyanosis, and hypotension. Each of these events was found to occur in less than 1.5% of the total patient population. Pretreatment with antihistamines and/or corticosteroids and reduced rate of infusion have allowed continued use of imiglucerase in most patients.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and diarrhea have been reported have been reported in less than 1.5% of the total patient population.

General

General side effects including fatigue, headache, abdominal pain, fever, dizziness, chills, and backache have been reported in less than 1.5% of the total patient population.

Local

Local side effects including discomfort, pruritus, burning, swelling or sterile abscess at the site of venipuncture. Each of these events was found to occur in less than 1% of the total patient population.

Cardiovascular

Cardiovascular side effects including tachycardia (less than 1.5%) have been reported. In addition to the adverse reactions that have been reported in patients treated with imiglucerase, transient peripheral edema has been reported for this therapeutic class of drug.

Dermatologic

Dermatologic side effects including rash (less than 1.5%) have been reported.

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