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Glucarpidase

Generic Name: glucarpidase (gloo-KAR-pid-ase)
Brand Name: Voraxaze

Glucarpidase is used for:

Treating dangerously high blood methotrexate levels in certain patients.

Glucarpidase is a carboxypeptidase. It works by converting methotrexate to an inactive substance.

Do NOT use glucarpidase if:

  • you are allergic to any ingredient in glucarpidase

Contact your doctor or health care provider right away if any of these apply to you.

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Before using glucarpidase:

Some medical conditions may interact with glucarpidase. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have normal kidney function

Some MEDICINES MAY INTERACT with glucarpidase. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Folates or similar medicines because their effectiveness may decreased by glucarpidase

This may not be a complete list of all interactions that may occur. Ask your health care provider if glucarpidase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use glucarpidase:

Use glucarpidase as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Glucarpidase is usually given as an injection at your doctor's office, hospital, or clinic.
  • If you are taking leucovorin, do not take it within 2 hours before or 2 hours after receiving glucarpidase.
  • Do not use glucarpidase if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of glucarpidase, contact your doctor right away.

Ask your health care provider any questions you may have about how to use glucarpidase.

Important safety information:

  • Rarely, an infusion reaction may occur with glucarpidase. Tell your doctor right away if you develop fever, chills, flushing, feeling hot, rash, hives, itching, throat tightness or breathing problems, tingling, numbness, or headache.
  • Lab tests, including kidney function and blood methotrexate levels, may be performed while you use glucarpidase and after you receive it. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: It is not known if glucarpidase can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using glucarpidase while you are pregnant. It is not known if glucarpidase is found in breast milk. If you are or will be breast-feeding while you use glucarpidase, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of glucarpidase:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); blurred vision; burning, numbness, or tingling; chills; fainting; fever; flushing of the skin; severe dizziness, drowsiness, or light-headedness; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of glucarpidase:

Glucarpidase is usually handled and stored by a health care provider. Keep glucarpidase out of the reach of children and away from pets.

General information:

  • If you have any questions about glucarpidase, please talk with your doctor, pharmacist, or other health care provider.
  • Glucarpidase is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take glucarpidase or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about glucarpidase. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to glucarpidase. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using glucarpidase.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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