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Generic Name: desogestrel/ethinyl estradiol (DES-oh-JES-trel/ETH-i-nil ES-tra-DYE-ol)
Brand Name: Examples include Desogen and Mircette

Cigarette smoking increases the risk of serious heart problems associated with use of Desogen. This risk increases with age and with heavy smoking. Women who are older than 35 years old have a greater risk. Women who are older than 35 years old and smoke should not use Desogen.


Desogen is used for:

Preventing pregnancy. It may also be used for other conditions as determined by your doctor.

Desogen is a combination progesterone and estrogen birth control pill. It works by preventing ovulation. It may also change the cervical mucus to prevent the sperm from reaching the egg and change the lining of the uterus to prevent a fertilized egg from implanting in the uterus.

Do NOT use Desogen if:

  • you are allergic to any ingredient in Desogen
  • you are pregnant or think you may be pregnant
  • you have blood clots (eg, in the legs, lungs, eyes) or a history of blood clots or blood clotting problems
  • you have chest pain caused by angina or a history of heart or brain blood vessel problems, heart attack, or stroke
  • you have known or suspected breast cancer or cancer of the lining of the uterus, cervix, or vagina
  • you have a history of breast cancer
  • you have abnormal vaginal bleeding of an unknown cause
  • you have certain heart valve problems, diabetes that affects circulation, uncontrolled high blood pressure, liver disease, or liver tumor or cancer, or a history of yellowing of the eyes or skin during pregnancy or previous birth control use
  • you have certain types of headaches or migraines with aura
  • you have had surgery and are or will be confined to a bed or a chair for an extended period of time
  • you are older than 35 years old and you smoke

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

Before using Desogen:

Some medical conditions may interact with Desogen. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of porphyria, diabetes or high blood sugar, gallbladder problems, heart problems (eg, angina), high blood pressure, high cholesterol or triglycerides, high blood calcium levels, kidney or liver problems, mental or mood problems (eg, depression), migraines or headaches, pancreas problems, or seizures
  • if you have endometriosis, growths in the uterus, abnormal mammogram, irregular menstrual periods, abnormal vaginal bleeding, a lump in the breast, or fibrocystic breast disease, or if a family member has had breast cancer
  • if a family member has a history of high blood triglyceride levels
  • if you are having surgery or will be confined to a bed or a chair for a long period of time
  • if you smoke, are very overweight, or have fluid retention or swelling problems

Some MEDICINES MAY INTERACT with Desogen. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Tranexamic acid because the risk of blood clots may be increased
  • Atorvastatin, azole antifungals (eg, ketoconazole), nonnucleoside reverse transcriptase inhibitors (NNRTIs) (eg, etravirine, nevirapine), protease inhibitors (eg, boceprevir, ritonavir), or rosuvastatin because they may decrease Desogen's effectiveness, resulting in pregnancy or breakthrough bleeding, or they may increase the risk of Desogen's side effects
  • Aprepitant, armodafinil, barbiturates (eg, phenobarbital), bosentan, carbamazepine, clobazam, colesevelam, felbamate, griseofulvin, hydantoins (eg, phenytoin), mifepristone, modafinil, oxcarbazepine, rifamycins (eg, rifampin), rufinamide, St. John's wort, topiramate, and troglitazone because they may decrease the effectiveness of Desogen, resulting in pregnancy or breakthrough bleeding
  • Cyclosporine, prednisolone, theophyllines, tizanidine, troleandomycin, and voriconazole because the risk of their side effects may be increased by Desogen
  • Clofibric acid, lamotrigine, morphine, temazepam, thyroid hormones (eg, levothyroxine), or valproic acid because their effectiveness may be decreased by Desogen

This may not be a complete list of all interactions that may occur. Ask your health care provider if Desogen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Desogen:

Use Desogen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Desogen. Talk to your pharmacist if you have questions about this information.
  • Take Desogen by mouth with or without food.
  • If you are also taking colesevelam, take it at least 4 hours before or after taking Desogen.
  • Eating grapefruit or drinking grapefruit juice while you are taking Desogen may increase the amount of Desogen in your blood, which may increase your risk for side effects. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
  • Talk with your doctor about how you should start to take your first pack of Desogen. If you begin to take Desogen during the first 24 hours of your period, you do not need to use an extra form of birth control. If you begin to take Desogen on the Sunday after your period starts, you will need to use an extra form of birth control (eg, condoms) for 7 days after you start taking Desogen.
  • To achieve maximum effectiveness of Desogen, it must be taken every day (every 24 hours) and at the same time each day.
  • For Desogen to be effective, it must be taken every day. Do not skip doses even if you do not have sex very often. Do not skip pills if you are spotting, bleeding, or nauseated. If you have these side effects and they do not go away, check with your doctor.
  • Be sure to have an extra full pack of this medication available at all times.
  • If you miss 1 dose of Desogen, take it as soon as you remember. Take your next dose at the regular time. This means you may take 2 doses on the same day. You do not need to use a backup method of birth control if you only miss 1 pill. If you miss more than 1 active dose of Desogen, read the extra patient information leaflet that comes with Desogen or contact you doctor for instructions. You must use a backup method of birth control if you miss more than 1 active dose of Desogen. If you are not sure about how to handle missed doses, use an extra form of birth control (eg, condoms) and talk with your doctor.

Ask your health care provider any questions you may have about how to use Desogen.

Important safety information:

  • Desogen may increase the risk of a stroke, a heart attack, blood clots, high blood pressure, or similar problems. The risk is greater if you smoke. Do not smoke or use other tobacco products while taking Desogen.
  • If you miss 2 periods in a row, or if you miss 1 period when you have not taken your pills correctly, contact your doctor right away to determine if you are pregnant.
  • Desogen may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths.
  • Tell your doctor or dentist that you take Desogen before you receive any medical or dental care, emergency care, or surgery. If possible, Desogen should be stopped at least 4 weeks before through 2 weeks after surgery or any time you might be confined to a bed or chair for a long period of time (eg, long plane flight, bed rest, lengthy illness).
  • You should usually not take Desogen within 4 weeks after giving birth or after a second-trimester abortion. Talk with your doctor about how to start taking Desogen in these instances.
  • Bleeding or spotting may occur while taking Desogen, especially during the first few months. Do not stop taking Desogen if this occurs. If bleeding or spotting is persistent, or if it occurs after menstrual cycles that were previously regular, contact your doctor.
  • Certain antibiotics, anticonvulsants, and other medicines may decrease the effectiveness of Desogen. Ask your pharmacist if you have questions about which medicines may decrease Desogen's effectiveness. To prevent pregnancy while taking these medicines, use an extra form of birth control (eg, condoms). You may also need to use an extra form of birth control for a period of time after you stop taking these medicines. Check with your doctor for more information.
  • If you wear contact lenses and you develop problems with them or other vision changes, contact your doctor.
  • Desogen does not stop the spread of HIV or other sexually transmitted diseases (STDs) to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection or an STD.
  • Diabetes patients - Desogen may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Desogen may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Desogen.
  • Lab tests, including breast exams, Pap tests, physicals, and blood pressure, may be performed while you use Desogen. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Examine your breasts monthly as directed by your doctor. Report any lumps right away.
  • Desogen should not be used in CHILDREN who have not had their first menstrual period; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Desogen if you are pregnant. If you think you may be pregnant, contact your doctor right away. Desogen is found in breast milk. Do not breast-feed while you are taking Desogen.

Possible side effects of Desogen:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast tenderness or enlargement; changes in appetite; changes in weight; dizziness; headache; loss of scalp hair; nausea; nervousness; stomach cramps or bloating; vaginal spotting or breakthrough bleeding; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody diarrhea; breast lumps, pain, or discharge; bulging eyes; calf or leg pain, swelling, redness, or tenderness; changes in vision (eg, double vision, vision loss); chest pain; coughing up blood; decreased urination; fainting; frequent or painful urination; migraines; missed menstrual period; mood or mental changes (eg, depression); persistent or recurrent abnormal vaginal bleeding; severe pain or tenderness in the stomach area; severe or persistent headache or dizziness; shortness of breath; swelling of fingers, hands, legs, or ankles; symptoms of heart attack (eg, chest, jaw, or arm pain; sudden severe nausea or vomiting; shortness of breath; sudden unusual sweating); symptoms of liver problems (eg, dark urine, fever, loss of appetite, pale stools, unusual tiredness, yellowing of the skin or eyes); symptoms of stroke (eg, one-sided weakness, slurred speech, confusion); trouble sleeping; vaginal discharge, itching, or odor; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Desogen:

Store Desogen at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Desogen out of the reach of children and away from pets.

General information:

  • If you have any questions about Desogen, please talk with your doctor, pharmacist, or other health care provider.
  • Desogen is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Desogen or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Desogen. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Desogen. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Desogen.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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