Chlorpheniramine/ dextromethorphan/ phenylephrine drops

Generic Name: chlorpheniramine/dextromethorphan/phenylephrine (KLOR-fen-IR-a-meen/DEX-troe-meth-OR-fan/FEN-il-EF-rin)
Brand Name: Examples include Bronkids and Neo DM

Chlorpheniramine/ dextromethorphan/ phenylephrine drops is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, itchy nose or throat, itchy or watery eyes, and cough due to colds, upper respiratory tract infections, and allergies. It may also be used for other conditions as determined by your doctor.

Chlorpheniramine/dextromethorphan/phenylephrine drops is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use chlorpheniramine/ dextromethorphan/ phenylephrine drops if:

  • you are allergic to any ingredient in chlorpheniramine/dextromethorphan/phenylephrine drops
  • you have severe or uncontrolled high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • you are unable to urinate or are having an asthma attack
  • you are taking droxidopa or sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using chlorpheniramine/ dextromethorphan/ phenylephrine drops:

Some medical conditions may interact with chlorpheniramine/dextromethorphan/phenylephrine drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of adrenal gland problems (eg, an adrenal gland tumor), heart problems (eg, fast, slow, or irregular heartbeat; heart disease), high or low blood pressure, low blood volume, diabetes, blood vessel problems, a stroke, glaucoma, increased pressure in the eye, trouble sleeping, or thyroid problems
  • if you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea); chronic cough; or if your cough produces large amounts of mucus
  • if you have a history of stomach or bowel ulcers; a blockage of your stomach, bladder, or bowel; kidney problems; an enlarged prostate or other prostate problems; or trouble urinating

Some MEDICINES MAY INTERACT with chlorpheniramine/dextromethorphan/phenylephrine drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or droxidopa because the risk of irregular heartbeat or a heart attack may be increased
  • Abiraterone, beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, linezolid, MAOIs (eg, phenelzine), selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram, fluoxetine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of chlorpheniramine/dextromethorphan/phenylephrine drops's side effects
  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by chlorpheniramine/dextromethorphan/phenylephrine drops
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by chlorpheniramine/dextromethorphan/phenylephrine drops

This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorpheniramine/dextromethorphan/phenylephrine drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use chlorpheniramine/ dextromethorphan/ phenylephrine drops:

Use chlorpheniramine/dextromethorphan/phenylephrine drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take chlorpheniramine/dextromethorphan/phenylephrine drops by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Use the dropper that comes with chlorpheniramine/dextromethorphan/phenylephrine drops to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of chlorpheniramine/dextromethorphan/phenylephrine drops and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use chlorpheniramine/dextromethorphan/phenylephrine drops.

Important safety information:

  • Chlorpheniramine/dextromethorphan/phenylephrine drops may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use chlorpheniramine/dextromethorphan/phenylephrine drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using chlorpheniramine/dextromethorphan/phenylephrine drops.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using chlorpheniramine/dextromethorphan/phenylephrine drops; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not take diet or appetite control medicines while you are taking chlorpheniramine/dextromethorphan/phenylephrine drops without checking with your doctor.
  • Before you start any new medicine, check the label to see if it has a decongestant, antihistamine, or cough suppressant in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not use chlorpheniramine/dextromethorphan/phenylephrine drops for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 5 to 7 days; if they go away and come back; if they get worse; if they occur along with a fever, rash, or persistent headache; or if new symptoms occur, check with your doctor.
  • Chlorpheniramine/dextromethorphan/phenylephrine drops may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to chlorpheniramine/dextromethorphan/phenylephrine drops. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Chlorpheniramine/dextromethorphan/phenylephrine drops may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking chlorpheniramine/dextromethorphan/phenylephrine drops for a few days before the tests.
  • Tell your doctor or dentist that you take chlorpheniramine/dextromethorphan/phenylephrine drops before you receive any medical or dental care, emergency care, or surgery.
  • Use chlorpheniramine/dextromethorphan/phenylephrine drops with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, nervousness, sleeplessness, and trouble urinating.
  • Caution is advised when using chlorpheniramine/dextromethorphan/phenylephrine drops in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • Different brands of chlorpheniramine/dextromethorphan/phenylephrine drops may have different dosing instructions for CHILDREN. They may also be indicated for different age ranges of children. Follow the dosing instructions that your doctor has given you. If you are unsure of the dose to give to your child or if you are unsure if chlorpheniramine/dextromethorphan/phenylephrine drops is appropriate for your child, check with your doctor or pharmacist.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using chlorpheniramine/dextromethorphan/phenylephrine drops while you are pregnant. It is not known if chlorpheniramine/dextromethorphan/phenylephrine drops is found in breast milk. Do not breast-feed while taking chlorpheniramine/dextromethorphan/phenylephrine drops.

Possible side effects of chlorpheniramine/ dextromethorphan/ phenylephrine drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; loss of coordination; mental or mood changes (eg, depression, nervousness); seizures; severe dryness of mouth, nose, or throat; severe or persistent dizziness, drowsiness, light-headedness, or headache; severe or persistent trouble sleeping; shortness of breath; tremor; unusual bruising or bleeding; unusual tiredness or weakness; vision problems (eg, double vision, severe or persistent blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; flushing; hallucinations; mental or mood changes; muscle spasms; seizures; severe dizziness, light-headedness, or headache; severe drowsiness; trouble breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of chlorpheniramine/dextromethorphan/phenylephrine drops:

Store chlorpheniramine/dextromethorphan/phenylephrine drops between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep chlorpheniramine/dextromethorphan/phenylephrine drops out of the reach of children and away from pets.

General information:

  • If you have any questions about chlorpheniramine/dextromethorphan/phenylephrine drops, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpheniramine/dextromethorphan/phenylephrine drops is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take chlorpheniramine/dextromethorphan/phenylephrine drops or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about chlorpheniramine/dextromethorphan/phenylephrine drops. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to chlorpheniramine/dextromethorphan/phenylephrine drops. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using chlorpheniramine/dextromethorphan/phenylephrine drops.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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