Paclitaxel use while Breastfeeding

Drugs containing Paclitaxel: Taxol, Onxol

Paclitaxel Levels and Effects while Breastfeeding

Summary of Use during Lactation

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. Based on limited data, paclitaxel appears to be excreted into milk in relatively large amounts. It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence, but the duration abstinence is not clear. In one case, paclitaxel was detectable in milk for at least a week, but not at 13 days after a dose of 30 mg per square meter.

Drug Levels

Maternal Levels. A woman with a history of treatment for thyroid cancer and recurrence during pregnancy was treated postpartum with paclitaxel and carboplatin. Her intravenous paclitaxel dose was 56.1 mg (20 mg per square meter) weekly for 6 weeks. Whole milk samples were obtained before her 6th dose and at 4, 28, 172, and 316 hours after the dose. The highest milk paclitaxel level was 1.17 mg/L in the 28-hour sample and paclitaxel was undetectable (<80 mcg/L) in the 317 hour sample. Metabolites were not measured. The average milk paclitaxel level over the 317 hour collection period was 0.78 mg/L, resulting in an estimated infant dose of 16.7% of the maternal dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Griffin SJ, Milla M, Baker TE et al. Transfer of carboplatin and paclitaxel into breast milk. J Hum Lact. 2012;28:457-9. PMID: 23087196

Paclitaxel Identification

Substance Name

Paclitaxel

CAS Registry Number

33069-62-4

Drug Class

Antineoplastic Agents

Administrative Information

LactMed Record Number

1013

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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