Natalizumab use while Breastfeeding

Drugs containing Natalizumab: Tysabri

Natalizumab Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of natalizumab during breastfeeding. Because natalizumab is a large protein molecule with a molecular weight of about 149,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, natalizumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. In a survey of women neurologists in the United States and Canada, 147 responded. Of these, 13% stated that they discourage breastfeeding with any immunomodulatory drug for their patient with multiple sclerosis, and 48% stated that they leave the decision on breastfeeding with interferon beta up to the patient.[1]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Inflammatory Bowel Disease) Budesonide, Infliximab, Mesalamine, Prednisone, (Multiple Sclerosis) Glatiramer Acetate, Interferon beta

References

1. Coyle PK, Christie S, Fodor P et al. Women Neurologists MS Initiative. Multiple sclerosis gender issues: clinical practices of women neurologists. Mult Scler. 2004;10:582-8. PMID: 15471377

Natalizumab Identification

Substance Name

Natalizumab

CAS Registry Number

189261-10-7

Drug Class

Antibodies, Monoclonal

Anti-Inflammatory Agents

Administrative Information

LactMed Record Number

716

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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