Hydrocortisone use while Breastfeeding
Drugs containing Hydrocortisone: Cortisporin Otic, Cortef, Solu-Cortef, Anusol-HC, Proctozone HC, Anusol-HC Suppositories, Cortifoam, Anucort-HC, Proctosol-HC, Hydrocortisone 1% In Absorbase, Show all 226 »Westcort, Analpram-HC, Cortizone-10, Cortaid, Proctofoam HC, Cipro HC, Cortisporin Ophthalmic Suspension, Hycort, Locoid, Pramosone, Epifoam, HC Pramoxine, Vosol HC, Proctocort, Hytone, Xerese, Antibiotic Ear, Locoid Lipocream, Ketocon+Plus, Cortisporin Ointment, AnaMantle HC, Hydrocortone, Analpram Advanced, Anusol HC-1, Acetasol HC, Analpram E, Vytone, Cortenema, Nutracort, Hydrocortisone with Aloe, Uremol HC, Texacort, Otocort Sterile Solution, Hemril-30, Hydrocort cream, Zypram, Cortane-B, Cortizone-10 Anal Itch Cream, Hysone, Cortisporin Ophthalmic Ointment, A-Hydrocort, LidaMantle HC, Xyralid, Cortizone-5, Scalacort, Proctocream-HC, Proctosert HC, Dermarest Eczema Medicated, Nupercainal HC 1%, Zolene HC, Otocort Sterile Suspension, Cortomycin, Zone-A, Neo/PolyB/HC, Hemorrhoidal HC, Cortaid with Aloe, Ala-Cort, Preparation H Anti-Itch Cream Hydrocortisone 1%, MD Hydrocortisone, Dermacort, Aeroseb-HC, Aquanil HC, Cortane, Delcort, Cortisporin Cream, Alcortin, Dermazene, Zoto-HC Drops, Itch-X Lotion, NuZon, Monistat Soothing Care Itch Relief Cream, Sarnol-HC, Genasone/Aloe, Proctozone-H, Corticaine, Cort-Dome, Cortisporin-TC, Ala-Quin, Earsol-HC, Lipsovir, Aero Otic HC, Coly-Mycin S, Coraz, Carmol HC, Ala-Scalp, Cortizone-10 Intensive Healing Formula, Keratol HC, Pediaderm HC, Aqua Glycolic HC, Hydropram, Xolegel CorePak, Lodocort Aloe, Novacort, Rectocort HC, Xyralid RC, NuCort with Aloe, Tucks Hydrocortisone Anti-Itch Ointment, Dermtex HC, Anuzone HC, Massengill Medicated Soft Cloth, Dermarest Dricort, Neutrogena T-Scalp, Cortizone-10 Plus, U-Cort, Otobiotic, Gynecort Maximum Strength, Encort, Cortaid Intensive Therapy, Cortaid Maximum Strength, Procto-Pak 1%, Rectacreme HC, Cortomycin Suspension, Cortizone for Kids, Scalacort DK, Zone-A Forte, Enzone, Drotic, Masporin Otic, Cort-Biotic, Cortatrigen, Pediotic, Otimar, Cortatrigen Modified, HC Pram, BP Ana-Lex HC, Lidazone HC, AnaMantle HC Forte, UAD Otic, Lidocort, AK-Spore HC Otic Suspension, Senatec HC, Oti-Sone, Xyralid LP, LidaMantle HC Relief, Peranex HC, RectaGel HC, Pramosone E, Cort-Dome High Potency, Oto-End, Cortane-B Lotion, Iodo-HC, Hydro Ear, Cortamox, Otirx, Cortic-ND, IvDerm, Steroform, Dek-Quin, FIRST Duke's Mouthwash, FIRST Mary's Mouthwash, Hydrocortone Phosphate, HC-Derma-Pax, 1 Plus 1 F, Vio-Tex-HC, Corque, Pedi-Cort V, Cyotic, Exotic-HC, Cortomycin Eye Ointment, Neo-Poly-Bac, Triple Antibiotic HC Ophthalmic Ointment, Neotricin HC, Ocu-Cort, Vasotate HC, Oticot HC, Alcortin A, Trioxin, MyOxin, Otozone, Tri-Otic, Otomar HC, Pramox-HC, Mantadil, Vanoxide-HC, Bencort, Ophthocort, Colocort, Cortalo with Aloe, Dermolate, Gly-Cort, Hi-Cor, Dermol HC, Corticreme, Acticort 100, Aloe Cort, Caldecort, Nogenic HC, Procort, Beta HC, Ivocort, Pandel, Scalp-Cort, Instacort 10, Recort Plus, Rederm, Scalp-Aid, Anusert HC-1, Anurx-HC, Procto-Kit 1%, Procto-Kit 2.5%, Anuprep-HC, Cetacort, Vagisil Satin Anti-Itch Creme, ProctoCare-HC, Instacort, Scalpicin, Rectasol-HC, Anumed-HC, Orabase HCA, Ala-Scalp HP, Anutone-HC, Lacticare-HC, Cotacort, Hemril-HC Uniserts, Penecort, Dermarest Plus Anti-Itch
Hydrocortisone Levels and Effects while Breastfeeding
Summary of Use during Lactation
Hydrocortisone (cortisol) is a normal component of breastmilk that passes from the mother's bloodstream into milk. Hydrocortisone has not been studied in breastmilk after exogenous administration in pharmacologic amounts. Although it is unlikely that dangerous amounts of hydrocortisone would reach the infant, a better studied alternate corticosteroid might be preferred. Use of hydrocortisone as an enema would not be expected to cause any adverse effects in breastfed infants. See also Hydrocortisone, Topical.
Maternal Levels. An unspecified number of mothers had endogenous breastmilk cortisol (hydrocortisone) levels measured at various random times postpartum. Milk cortisol levels ranged from 7 to 33 mcg/L during the first 10 days postpartum; levels after 40 days postpartum were 6 to 17 mcg/L.
Cortisol was measured in the colostrum and milk of 11 women monthly for up to 12 months postpartum. Levels in late pregnancy averaged 24.5 mcg/L and fell over the first 10 days postpartum to an average of 1.8 mcg/L. Milk cortisol levels between months 2 and 12 averaged 7.2 mcg/L, but varied with time and among individuals (range 0.2 to 32 mcg/L).
Free cortisol was measured in 13 women on days 1, 2, and 3 postpartum (7 spontaneous births) or days 3, 4, and 5 postpartum (6 elective cesarean sections). Milk levels were measured before and after nursing, but the values were not statistically different. In the women with spontaneous deliveries, before and after milk levels averaged 17.2 mcg/L on day 1, 16.8 mcg/L on day 2, and 7.4 mcg/L on day 3 postpartum. In the women with cesarean deliveries, before and after milk levels averaged 26.5 mcg/L on day 3, 15.1 mcg/L on day 4, and 14.1 mcg/L on day 6 postpartum.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
None reported with any systemic corticosteroid.
Possible Effects on Lactation
Published information on the effects of hydrocortisone on serum prolactin or on lactation in nursing mothers was not found as of the revision date.
A study of 46 women who delivered an infant before 34 weeks of gestation found that a course of another corticosteroid (betamethasone, 2 intramuscular injections of 11.4 mg of betamethasone 24 hours apart) given between 3 and 9 days before delivery resulted in delayed lactogenesis II and lower average milk volumes during the 10 days after delivery. Milk volume was not affected if the infant was delivered less than 3 days or more than 10 days after the mother received the corticosteroid. An equivalent dosage regimen of hydrocortisone might have the same effect.
A study of 87 pregnant women found that betamethasone given as above during pregnancy caused a premature stimulation of lactose secretion during pregnancy. Although the increase was statistically significant, the clinical importance appears to be minimal. An equivalent dosage regimen of hydrocortisone might have the same effect.
Alternate Drugs to Consider
1. Rosner W, Beers PC, Awan T, Khan MS. Identification of corticosteroid-binding globulin in human milk: measurement with a filter disk assay. J Clin Endocrinol Metab. 1976;42:1064-73. PMID: 932172
2. Kulski JK, Hartmann PE. Changes in the concentration of cortisol in milk during different stages of human lactation. Aust J Exp Biol Med Sci. 1981;59 (Pt 6):769-78. PMID: 7340774
3. Patacchiolo FR, Cigliana G, Cilumbriello A et al. Maternal plasma and milk free cortisol during the first 3 days of breast-feeding following spontaneous delivery or elective cesarean section. Gynecol Obstet Investig. 1992;34:159-63. PMID: 1427417
4. Henderson JJ, Hartmann PE, Newnham JP, Simmer K. Effect of preterm birth and antenatal corticosteroid treatment on lactogenesis ii in women. Pediatrics. 2008;121:e92-100. PMID: 18166549
5. Henderson JJ, Newnham JP, Simmer K, Hartmann PE. Effects of antenatal corticosteroids on urinary markers of the initiation of lactation in pregnant women. Breastfeed Med. 2009;4:201-6. PMID: 19772378
CAS Registry Number
- Corticosteroids, Systemic
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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