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Hydrocortisone use while Breastfeeding

Drugs containing Hydrocortisone: Cortisporin Otic, Anusol-HC, Proctozone HC, Cortef, Solu-Cortef, Proctosol-HC, Anucort-HC, Westcort, Analpram-HC, Anusol-HC Suppositories, Show all 237 »Hydrocortisone 1% In Absorbase, Cortisporin Ophthalmic Suspension, Locoid, Pramosone, Proctofoam HC, Cortisporin-TC, Hytone, Cortizone-10, Cortaid, Cipro HC, Otomar HC, Coly-Mycin S, Epifoam, Cortifoam, Oticin HC, Xerese, Proctocream-HC, Preparation H Anti-Itch Cream Hydrocortisone 1%, Ana-Lex, Cortisporin Ophthalmic Ointment, Triple Antibiotic HC Ophthalmic Ointment, Vytone, Alcortin, Colocort, Cortenema, A-Hydrocort, Procto-Pak 1%, Vosol HC, Proctocort, HC Pramoxine, Exotic-HC, Scalpicin, Analpram Advanced, Trioxin, Locoid Lipocream, Antibiotic Ear, Instacort, Cortisporin Ointment, Cortane-B, Aeroseb-HC, Hydrocortone, Cetacort, Procort, Acetasol HC, Hemmorex-HC, Recort Plus, Pramcort, Anuzone HC, Zypram, Ala-Cort, Cortane, Cortisporin Cream, Hycort, Hydrocort cream, Hemril-HC Uniserts, Cortizone-10 Intensive Healing Formula, Rectacort-HC, Dermacort, Texacort, Rectasol-HC, Dermol HC, LidaMantle HC, AnaMantle HC, Lipsovir, Alcortin A, RectaGel HC, Senatec HC, Oticot HC, Uremol HC, Lidazone HC, Drotic, Otocort Sterile Solution, Corticaine, Anusol HC-1, Aloe Cort, Pandel, Cortizone for Kids, Pediotic, ProctoCare-HC, Proctozone-H, Acticort 100, Penecort, HC-Derma-Pax, Dermasorb AF, Vio-Tex-HC, Oto-End, Cortic-ND, Zolene HC, Analpram E, Neotricin HC, Pramox-HC, Novacort, Aero Otic HC, Ala-Quin, MyOxin, Monistat Soothing Care Itch Relief Cream, Nutracort, Dermazene, Oti-Sone, Cort-Biotic, Otobiotic, Xolegel CorePak, Ketocon+Plus, Lodocort Aloe, NuCort with Aloe, U-Cort, Cortaid Maximum Strength, Proctosert HC, Hemril-30, Dermtex HC, Cortizone-10 Plus, Cortaid Intensive Therapy, Encort, Cortatrigen, Cortalo with Aloe, Dermarest Eczema Medicated, Gynecort Maximum Strength, Tucks Hydrocortisone Anti-Itch Ointment, NuZon, Aqua Glycolic HC, Peranex HC, HC Pram, Zone-A, Cortatrigen Modified, Masporin Otic, AK-Spore HC Otic Suspension, Enzone, Zone-A Forte, Scalacort DK, Massengill Medicated Soft Cloth, Pramosone E, Hydropram, Rectocort HC, Cortomycin, Otimar, AnaMantle HC Forte, Rectacreme HC, Xyralid, Xyralid LP, BP Ana-Lex HC, LidaMantle HC Relief, Lidocort, Neo/PolyB/HC, Otocort Sterile Suspension, Cortomycin Suspension, Coraz, Xyralid RC, UAD Otic, Procto-Kit 1%, 1 Plus 1 F, FIRST Duke's Mouthwash, FIRST Mary's Mouthwash, Pedi-Cort V, Hysone, Iodo-HC, Steroform, Dek-Quin, Hydrocortone Phosphate, Vagisil Satin Anti-Itch Creme, Hydrocortisone with Aloe, Dermasorb HC, Cort-Dome High Potency, NuCort, Keratol HC, Carmol HC, MD Hydrocortisone, Ala-Scalp, Corque, Cortane-B Lotion, Ocu-Cort, Bencort, Vanoxide-HC, Neo-Poly-Bac, Cortomycin Eye Ointment, Vasotate HC, Earsol-HC, Neo-Polycin HC, Ophthocort, Mantadil, IvDerm, Cortamox, Hydro Ear, Otirx, Cyotic, Otozone, Zoto-HC Drops, Tri-Otic, GRx HiCort 25, Procto-Kit 2.5%, Scalp-Aid, Cort-Dome, Genasone/Aloe, Sarnol-HC, Rederm, Gly-Cort, Hi-Cor, Nogenic HC, Instacort 10, Scalp-Cort, Dermarest Plus Anti-Itch, Cortizone-5, Neutrogena T-Scalp, Nupercainal HC 1%, Bioelements Immediate Comfort, Beta HC, Ivocort, Cortizone-10 Anal Itch Cream, Scalacort, Dermolate, Ala-Scalp HP, Hemorrhoidal HC, Anutone-HC, Orabase HCA, Lacticare-HC, Anuprep-HC, Anumed-HC, Cotacort, Anurx-HC, Anusert HC-1, Corticreme, Delcort, Pediaderm HC, Itch-X Lotion, Caldecort, Cortaid with Aloe, Aquanil HC, Dermarest Dricort

Hydrocortisone Levels and Effects while Breastfeeding

Summary of Use during Lactation

Hydrocortisone (cortisol) is a normal component of breastmilk that passes from the mother's bloodstream into milk. Hydrocortisone has not been studied in breastmilk after exogenous administration in pharmacologic amounts. Hydrocortisone in breastmilk is stable at room temperature and during repeated freeze-thaw cycles.[1]

Although it is unlikely that dangerous amounts of hydrocortisone would reach the infant, a better studied alternate corticosteroid might be preferred. Use of hydrocortisone as an enema would not be expected to cause any adverse effects in breastfed infants. Local injections, such as for tendinitis, would not be expected to cause any adverse effects in breastfed infants, but might occasionally cause temporary loss of milk supply. See also Hydrocortisone, Topical.

Drug Levels

Numerous methods have been used to measure cortisol in milk. Some have measured only unconjugated cortisol and others have hydrolyzed sulfate and glucuronide conjugates to measure total cortisol. Neonates are unable to deconjugate these moieties, so the age of the infant affects the relevance of findings.[1]

Maternal Levels. Cortisol was measured in the colostrum and milk of 11 women monthly for up to 12 months postpartum. Levels in late pregnancy averaged 24.5 mcg/L and fell over the first 10 days postpartum to an average of 1.8 mcg/L. Milk cortisol levels between months 2 and 12 averaged 7.2 mcg/L, but varied with time and among individuals (range 0.2 to 32 mcg/L).[2]

Free cortisol was measured in 13 women on days 1, 2, and 3 postpartum (7 spontaneous births) or days 3, 4, and 5 postpartum (6 elective cesarean sections). Milk levels were measured before and after nursing, but the values were not statistically different. In the women with spontaneous deliveries, before and after milk levels averaged 17.2 mcg/L on day 1, 16.8 mcg/L on day 2, and 7.4 mcg/L on day 3 postpartum. In the women with cesarean deliveries, before and after milk levels averaged 26.5 mcg/L on day 3, 15.1 mcg/L on day 4, and 14.1 mcg/L on day 6 postpartum.[3]

Thirteen full-term mothers donated milk between 8 and 28 weeks postpartum. Unconjugated cortisol concentrations ranged from 1.45 to 8.34 mcg/L.[1] Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

None reported with any systemic corticosteroid.

Effects on Lactation and Breastmilk

Published information on the effects of hydrocortisone on serum prolactin or on lactation in nursing mothers was not found as of the revision date. However, medium to large doses of depot corticosteroids injected into joints have been reported to cause temporary reduction of lactation.[4][5]

A study of 46 women who delivered an infant before 34 weeks of gestation found that a course of another corticosteroid (betamethasone, 2 intramuscular injections of 11.4 mg of betamethasone 24 hours apart) given between 3 and 9 days before delivery resulted in delayed lactogenesis II and lower average milk volumes during the 10 days after delivery. Milk volume was not affected if the infant was delivered less than 3 days or more than 10 days after the mother received the corticosteroid.[6] An equivalent dosage regimen of hydrocortisone might have the same effect.

A study of 87 pregnant women found that betamethasone given as above during pregnancy caused a premature stimulation of lactose secretion during pregnancy. Although the increase was statistically significant, the clinical importance appears to be minimal.[7] An equivalent dosage regimen of hydrocortisone might have the same effect.

Alternate Drugs to Consider

(Systemic) Methylprednisolone, Prednisolone, Prednisone

References

1. van der Voorn B, Martens F, Peppelman NS et al. Determination of cortisol and cortisone in human mother's milk. Clin Chim Acta. 2015;444:154-5. PMID: 25687161

2. Kulski JK, Hartmann PE. Changes in the concentration of cortisol in milk during different stages of human lactation. Aust J Exp Biol Med Sci. 1981;59 (Pt 6):769-78. PMID: 7340774

3. Patacchiolo FR, Cigliana G, Cilumbriello A et al. Maternal plasma and milk free cortisol during the first 3 days of breast-feeding following spontaneous delivery or elective cesarean section. Gynecol Obstet Investig. 1992;34:159-63. PMID: 1427417

4. McGuire E . Sudden loss of milk supply following high-dose triamcinolone (Kenacort) injection. Breastfeed Rev. 2012;20:32-4. PMID: 22724311

5. Babwah TJ, Nunes P, Maharaj RG. An unexpected temporary suppression of lactation after a local corticosteroid injection for tenosynovitis. Eur J Gen Pract. 2013;19:248-50. PMID: 24261425

6. Henderson JJ, Hartmann PE, Newnham JP, Simmer K. Effect of preterm birth and antenatal corticosteroid treatment on lactogenesis ii in women. Pediatrics. 2008;121:e92-100. PMID: 18166549

7. Henderson JJ, Newnham JP, Simmer K, Hartmann PE. Effects of antenatal corticosteroids on urinary markers of the initiation of lactation in pregnant women. Breastfeed Med. 2009;4:201-6. PMID: 19772378

Hydrocortisone Identification

Substance Name

Hydrocortisone

CAS Registry Number

50-23-7

Drug Class

Corticosteroids, Systemic

Glucocorticoids

Anti-Inflammatory Agents

Administrative Information

LactMed Record Number

138

Last Revision Date

20160204

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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