Eculizumab use while Breastfeeding

Drugs containing Eculizumab: Soliris

Eculizumab Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited information indicates that maternal doses of eculizumab 900 mg daily produce undetectable levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.

Drug Levels

Maternal Levels. One woman was receiving eculizumab 900 mg every 21 days during pregnancy and the immediate postpartum period. No eculizumab was detected in the breast milk during the first week after delivery. The time since the last dose and limit of detection were not mentioned in the abstract.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Kelly R, Arnold LM, Richards SJ et al. Successful pregnancy outcome in paroxysmal nocturnal haemoglobinuria on long term eculizumab. Haematologica. 2009;94 (Suppl. 2):452. Abstract.

Eculizumab Identification

Substance Name

Eculizumab

CAS Registry Number

219685-50-4

Drug Class

  • Antibodies, Monoclonal

Administrative Information

LactMed Record Number

785

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2009-09-29

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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