Doxazosin use while Breastfeeding

Drugs containing Doxazosin: Cardura, Cardura XL, Cascor, Carduran, Doxadura

Doxazosin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited information indicates that maternal doses of 4 mg daily produce low very levels in milk and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Maternal Levels. A woman who was nursing a 6-month-old infant received 2 doses of doxazosin 4 mg 24 hours apart. Four milk samples were obtained after the second dose. A peak milk level of 4.2 mcg/L occurred at 1 hour after the dose. The average concentration over the 18-hour study period was 2.9 mcg/L. The authors estimated that a fully breastfed infant would receive an average daily dosage of 440 ng/kg daily or about 0.6% of the maternal weight-adjusted dosage.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. However, the pharmacologically similar drug prazosin does not affect serum prolactin concentration in patients with hypertension,[2][3] indicating that doxazosin may not affect prolactin levels. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Jensen BP, Dalrymple JM, Begg EJ. Transfer of doxazosin into breast milk. J Hum Lact. 2013;29:150-3. (corrected in J Hum Lact 2014 30: NP3-NP4). PMID: 23439864

2. Barbieri C, Caldara R, Ferrari C et al. Metabolic effects of prazosin. Clin Pharmacol Ther. 1980;27:313-6. PMID: 6102000

3. Barbieri C, Ferrari C, Borzio M et al. Metabolic effects of chronic prazosin treatment. Horm Metab Res. 1980;12:331-4. PMID: 6105121

Doxazosin Identification

Substance Name

Doxazosin

CAS Registry Number

74191-85-8

Drug Class

Adrenergic alpha-Antagonists

Antihypertensive Agents

Administrative Information

LactMed Record Number

745

Last Revision Date

20141003

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide
(web1)