Why is it preferable to apply Androgel in the morning? As opposed to the evening? Wouldn't?

I have been on testosterone 12.5% gel for 2 months. First month and half I was applying gel in the am. Then I tried it at 8 pm, after bath. Before I changed to nights, I did not really see change in sleep pattern. 1 week moving to night, I have spent 3 nights with no sleep at all. Today going back to am. Dr says he has not seen positive results from blood work, yet. Praying it works.

I think they are both right about when Andro-gel testosterone should be taken and for what reason. There aren't any studies of evening testosterone dosing but it is true that testosterone levels peak in the mornings (AM). I know when I take it any time, I'm more alert and would have trouble sleeping if it were in the evening but then I don't have a night time job, if I did, I'd probably take Andro-gel in the evenings (PM).

What about for trans men? I have been taking it for a few weeks and I haven't really noticed any changes except feeling sick and slightly having a lower voice. Do you guys think it would work better if I used it in the morning?

Everything he said is true, but a pharmacist that works for the manufacture of Androgel told me the main reason is because morning is the time of day when the body would naturally have its highest testosterone levels or peak. Androgel causes testosterone to peak shortly after (within hours) of application. So all said and done, it is to keep, as close as possible, with your body's hormonal balance... as it would be naturally in a healthy adult male without hypogonadism.

The assumption is that the longer the gel sets upon your skin, the longer it is available to be absorbed. Therefore, if you apply it first thing in the morning, you have the longest period of time in contact with your skin.

Someone who applies the gel in the evening, is likely to lay down and fall asleep. That means a lower metabolism and less active body, so blood circulation falls, etc. Also, there is a greater chance that you'll be moved to engage in skin-to-skin contact with your partner during the night, which is warned against in all the literature.

So, the best timing is the morning for the longest period of exposure for you (even under your clothes) and the least chance of cross-contaimination.