I’ve been on Zoloft for 3 years, and decided to reduce the dose due to weight gain. I went down a bit too far and had a recurrent episode because of changes happening in my life currently. I didn’t want to go all the way back to 150mg because of the weight issue. This brings me to the crux of this post...

I’ve been on Wellbutrin 150mg XL for 3 weeks now (so obviously not up to therapeutic levels in the system yet) to augment the Zoloft and maybe, just maybe, replace Zoloft down the road because of the weight gain side effect. I started drinking coffee again about a week ago and had to stop today. I was starting to have serious issues with nervous stomach and general discomfort, as well as my appetite being destroyed. Caffeine and Zoloft were no problem, but now that I’ve been on the introductory dose of Wellbutrin for 3 weeks I’m not handling the caffeine super well. It’s also making me a bit depressed/anxious and I’m thinking about sex more. My question is should I wait to re-introduce caffeine until the Wellbutrin has had a chance to do its thing, and/or wait until I get to the proper dose since I may have to go up more? What do people think?

Thanks much!