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Does Auvelity cause weight gain or loss?

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 8, 2023.

Official answer

by Drugs.com

Weight gain has not been reported with Auvelity, but in one 6-week study, participants lost, on average, half a pound, while those taking placebo gained about one pound. Animal studies have also reported that the administration of dextromethorphan/bupropion did not affect body weight, weight gain, or food consumption.

References
  • Auvelity Prescribing Information. https://www.axsome.com/auvelity-prescribing-information.pdf
  • Auvelity FAQs. https://www.auvelity.com/resources#faq

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Auvelity worked significantly better than Wellbutrin (bupropion) at relieving symptoms of depression in a small randomized double-blind, parallel trial that lasted for 6 weeks. It also had a faster onset of effect, with improvement in the Montgomery-Åsberg Depression Rating Scale (MADRS) score being observed as early as week 1 and differences being statistically significant by week 2. Continue reading

Both Auvelity and Wellbutrin are effective for depression but a small RCT (n=80) reported that Auvelity worked significantly better than Wellbutrin and took less time to start working. 43 people prescribed Auvelity experienced an overall decrease in their Montgomery-Åsberg Depression Rating Scale (MADRS) score of 13.7 points after 6 weeks compared to a decrease of 8.8 points in the 37 people prescribed bupropion (least-squares mean difference=-4.9; 95% CI=-3.1, -6.8). Continue reading

Auvelity may start to lessen your symptoms of depression after one week of treatment. The percentage of patients who achieved symptoms that were “very much improved / much improved” at one week were 22% for Auvelity vs. 13% for placebo, a significant effect. In studies, over 50% of patients achieved a clinical response by the 6th week of treatment. Continue reading

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