I will be starting the medication next week and am terrifed of gaining weight. I'm on the hearvier side which has a lot to do with my depression, anxiety, negative self-image, mood swings etc. If I eat healthy and exercise, what are the chances that I will gain weight? In other words, does it make you eat more or does it contain some sort of chemical that adds pounds beyond my control? Any advise would be extremely helpful.
3 Jul 2012
Several side effects are possible with Depakote, and weight gain does appear to be one of them. This data comes from clinical trials that extensively studied Depakote and documented its side effects.
Up to 9% of people taking Depakote reported weight gain. This was most common in people taking the drug for migraine prevention (8%) or for complex partial seizures (9%).
Depakote has a tendency of people who take it may gain weight, some suggestions include: Eating a heart-healthy diet. This diet should include: Lots of fruits, vegetables, grains, and fat-free or low-fat milk and milk products; lean meats, poultry, fish, beans, eggs, and nuts; limited amounts of saturated fats, trans fats, cholesterol, sodium (salt), and added sugars. Participating in regular physical activity for at least 30 minutes a day on most days of the week. Limiting your intake of alcohol.
If the weight gain continues, the doc may recommend other lifestyle changes or possibly switching to a different migraine, bipolar disorder, or epilepsy medicine.
Take care, best wishes!
3 Jul 2012
Depakote made me gain weight. I found that I craved sweets more, ate more and eventaully packed on the pounds. When I stopped the depakote I quickly lost 10 lbs. If you control what you eat, don't give into the cravings and exercise, you should be able to ward off any major weight gain.
3 Jul 2012
I was on this stuff for 5 months. Aside from the blood tests to monitor Valporic Acid there were no other hassles with it. It had no impact on my appetite or my weight. My wife was put on it for her migraine's and the Dr got her so worked up about the possibility of weight gain she asked to stop taking it after just 10-days, she had not gained any weight in that time.
I just looked this up and saw that 9% (nine) percent of people reported weight gain. Best I can say is monitor your weight and if you see it start to go up from the med tell your Dr., maybe there's an alternative. Best to you; Hope this helps.
13 Jul 2012
Honestly, my findings here. It is the only drug I have consumed non-stop for the past eight years. When combined with ZYPREXA, yes, absolutely it seems to be a given that big weight gain will occur. But I had zero weight gain when I combined it with Abilify. Now I take a relatively large dose of it alone (1,250mgs)... have been on the large dose since January, and my weight has remained constant at 118lbs. So although Rajive says that statistically 10% report weight gain, I say what about the other 90% who don't find this! Now of course I am fanatical about monitoring my weight... step on the scales daily, watch my diet like a hawk, and walk a good old 5 miles daily; probably just as any person who is trying to be weight conscious would do. So it would be my bet that if you can adhere to these lifestyle habits, there is no good reason why the pounds should stack on.
And in fact, you might have an "edge" on your pals who hare NOT worrying about weight gain; because this gives you an added motivation to be extra fussy with yourself! So try it, watch the scales, and work hard at weight control. And soon you might just put us all to shame with the "new you"!!! Kathleen
28 Jan 2013
My 19 yo daughter is taking one med. 750mg depakote for 5 months now. She has put on about 30lbs despite while eating an extremely healthy diet. Every bite, meal and snack is measured and counted. Prior to taking this med she was naturally thin ate anything anytime she wanted. Now she constantly fights hunger despite a well balanced diet. The challenge is that though it is not a perfect solution to her Bi Polar mood swings she is far more stable and productive. If the weight gain continues as it does not seem to be leveling off then not only will she be dealing with self esteem issues for the first time in life related to weight but her weight will become a new health issue itself. so while some do not have weight gain issues many do and based on what my daughter is dealing with diet and excersice is not counter acting the drugs effect.
8 Jan 2014
I have been on Depakote for about 10 years now.(between 1500mg and 2000mg dosages) Upon first starting the medication, I gained 40 lbs in 3 months. I have been told that this amount of gain in a short time is rare... lucky me. I stay on the med as it is the only one to control my seizures. But it did make me fat.
3 Mar 2014
Absolutly weight gain is a possible side effect. It is noted as a side effect. My daughter gained 65 pounds in 9 months. Another side effect she suffered that was the final straw were tremors and the possibility of them becoming permanent. When she changed doctors another potential issue was brought up. We ere told it should never be given to someone up during child bearing years. Weight gain is a potential side effect in most of the drugs in this class. The drug was effective in stabilizing her BiPolar.
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