I noticed some of the pills (though of the same dosage) have sometime an NRP imprint or S489 imprint on the other side of the pill. To me, the ones with S489 are like placebo! Anyone else noticed or sensed this?? I am over-senstive and very alert to how medicine works. Thanks.
Vyvanse NRP vs Vyvanse S489?
Question posted by Ms. Common Sense on 17 June 2010
Last updated on 4 November 2023 by joisAn
6 Answers
joisAn
4 Nov 2023
Since late 2022 and thus far during all of 2023 I have noticed my Vyvanse RX did not seem to be working. I told my Doctor and she increased the dosage. I never looked at the NRP imprint until I read your comments. I just checked a couple of capsules left over from early 2022 and my recent refill in 2023 the imprint is 489 on both capsules. Maybe that is why my RX has not worked for me the past year or so. My doctor sent in the RX for higher dosage in June but local pharmacies did not have the higher dosage because of supply issues due to manufacturing delays. So I have continued at the lower dose. This afternoon I received my new RX with the higher dosage and will begin taking the higher dose tomorrow -- the imprint is 489. I’ll comment in a week or so about whether the higher dose is working. It could be the capsules imprinted with 489 is the culprit not the dose.
BrandisB
13 Feb 2023
Personally, no I didn't even know there were two different kinds. I get the S489 version and it seems to work great. I was recently in a psychiatric hospital and they gave me 20mg which worked great even after dropping me 40mg. However, I was eating much better, including a large breakfast and only one cup of coffee. Now that has changed and I don't eat a very large or healthy breakfast. I drink many cups of coffee and have to take supplements such as a pre-workout to feel the effects of my medication working such as focus, motivation, and all-around energy. I am also on other medications. I feel great today but had to take a pre-workout. I don't think I would feel it at all if I didn't take a pre-workout.
greenpoor
26 Sep 2022
Call your manufacturer first! Write the lot number and date the prescription was filled even before you call.
Just since Feb-March 2020 my local pharmacies volume of prescriptions, vaccines, etc. has exploded, and I believe local pharmacists, pharmacy techs need all the relief you can give them.
Manufacturers are more likely to hear about issues, or questions about products as they receive reports from across the entire country.
Always ask & record the name or employee # or ID # if the person won't share their name, the day/ date & time of your call whether you call your pharmacy or manufacturer.
Different companies have different names for the same employee: product safety, customer support, customer service, help, etc; if the Rx product has large annual sales it may have a dedicated group of employees in a section just for that specific product.
Never hesitate to ask your contact to repeat something, or to speak more slowly, or to spell words you don't know.
If you call when the pharmacy is overwhelmed, buried w new and prescription refills, imagine the stress n inadvertent error possibility?
Depending on the Rx medication and online or telephone access to community groups, especially w pediatric and senior citizen Rx medications may also be a resource to consider?
If the information you receive just doesn't feel right, you have a "gut reaction" call at another day or time. Consider reporting your issues & concerns to the FDA, initially, before calling the manufacturer or your pharmacy. FDA has a toll-free number to call, as well as an online form you can complete, or print out and mail to the FDA.
Trust your senses, your intuition, whatever you call the basis of your reaction.
your majesty
15 July 2022
I’m looking for the same answer. The S489 are different for some reason. One thing is that the capsule coating is not as shiny as the other ones.
lilyblue
21 June 2022
I noticed the capsule color and imprint changes with the dosage. As I have gone from 30 to 50,60, and 70… (as there is no FDA approved generic for Vyvanse).
sbh12nw
11 Nov 2010
Oh my God, yes! My son takes vyvanse 20 mg and has always done well on it. I refilled his prescription 2 days ago and noticed his behavior was different, unfocused and starting to have eye ticks. I checked his medicine to see if the pharmacy made a mistake and saw the S489 on the pill but the label said NRP 104. I believe their is definitely something different about the formulas. Now what am I going to do? The pharmacy says its the right medicine.
psych0tr0picnewbie
11 July 2017
APOLOGIES!! Waaaaaayyyy past post date (any answered inquiries about formulated meds consistency?
Related topics
vyvanse, chronic fatigue syndrome (cfs)
Further information
- Vyvanse uses and safety info
- Vyvanse prescribing info & package insert (for Health Professionals)
- Side effects of Vyvanse (detailed)
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