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Antipsychotics Don't Ease Delirium in Hospitalized Patients

Posted 29 Mar 2016 by Drugs.com

TUESDAY, March 29, 2016 – Antipsychotic medications, such as haloperidol (Haldol) or clozapine (Clozaril), aren't appropriate for preventing or routinely treating delirium in hospitalized patients, a new study suggests. The researchers reviewed past studies and found that antipsychotic drugs given before surgery didn't prevent delirium. These drugs also didn't make any difference in the course of delirium in medical or surgical patients, the study authors said. "The American Geriatrics Society guidelines suggest avoiding using these medications as a part of routine care of a patient with delirium," said lead researcher Dr. Karin Neufeld, clinical director of psychiatry at Johns Hopkins Bayview Medical Center in Baltimore. Delirium causes confused thinking and diminished awareness of the environment, such as time and place. Delirium is often caused by physical or mental illness, such as ... Read more

Related support groups: Seroquel, Abilify, Lithium, Latuda, Risperdal, Zyprexa, Risperidone, Geodon, Saphris, Seroquel XR, Quetiapine, Olanzapine, Haldol, Psychiatric Disorders, Invega, Clozapine, Haloperidol, Compazine, Aripiprazole, Prochlorperazine

Antipsychotic Drugs Tied to Risk of Early Death in Parkinson's Patients

Posted 22 Mar 2016 by Drugs.com

TUESDAY, March 22, 2016 – New research suggests that Parkinson's patients who are given antipsychotics to treat dementia and psychosis may be more likely to die early. However, the medications provide important benefits and the study authors aren't suggesting that these patients stop taking them. And it's still not clear exactly why there seems to be an increased risk of early death. "This [study] does not necessarily answer whether the drugs themselves lead to more deaths, or if it's instead the reasons they were prescribed," said Dr. Mark Baron, interim director of Virginia Commonwealth University's Parkinson's Disease and Movement Disorders Center. He wrote a commentary accompanying the new study. Antipsychotic drugs, despite their name, are used to treat a variety of mental conditions other than psychosis, including anxiety and dementia. As many as 60 percent of long-term ... Read more

Related support groups: Seroquel, Risperdal, Zyprexa, Risperidone, Parkinson's Disease, Seroquel XR, Quetiapine, Agitation, Psychosis, Olanzapine, Haldol, Agitated State, Psychiatric Disorders, Haloperidol, Symbyax, Thorazine, Zyprexa Zydis, Chlorpromazine, Risperdal Consta, Haldol Decanoate

Schizophrenia Tied to Much Higher Risk of Suicide Attempts

Posted 19 Feb 2016 by Drugs.com

THURSDAY, Feb. 18, 2016 – Schizophrenia patients are at significantly increased risk of attempting suicide, a new study finds. Researchers analyzed data from more than 21,700 Canadians, including 101 who had been diagnosed with schizophrenia. About 39 percent of people (two in five) with schizophrenia had attempted suicide, compared with about 3 percent of people without the mental health disorder. "Even after taking into account most of the known risk factors for suicide attempts, those with schizophrenia had six times the odds of having attempted suicide in comparison to those without schizophrenia," study author Esme Fuller-Thomson said in a University of Toronto news release. Fuller-Thomson is a professor of social work at the university. When researchers focused only on the 101 individuals with schizophrenia, they found that "women and those with a history of drug or alcohol abuse ... Read more

Related support groups: Depression, Wellbutrin, Seroquel, Abilify, Major Depressive Disorder, Lithium, Amitriptyline, Viibryd, Bupropion, Schizophrenia, Wellbutrin XL, Mirtazapine, Remeron, Nortriptyline, Latuda, Risperdal, Elavil, Zyprexa, Risperidone, Schizoaffective Disorder

Drug Helps Those With Tough-to-Treat Schizophrenia: Study

Posted 25 Nov 2015 by Drugs.com

WEDNESDAY, Nov. 25, 2015 – The drug clozapine reduces symptoms in schizophrenia patients who don't benefit from other antipsychotic medications, a new study indicates. The finding, culled from an analysis of Medicaid data on more than 6,200 patients with treatment-resistant schizophrenia, was published recently in the American Journal of Psychiatry. "These results give clinicians important guidance for how to help an extremely vulnerable group of people," said study author Dr. T. Scott Stroup, a professor of psychiatry at Columbia University Medical Center in New York City and a research psychiatrist at New York State Psychiatric Institute. "By helping individuals with treatment-resistant schizophrenia get effective treatment sooner, we can expect better outcomes," Stroup said in a Columbia news release. Antipsychotic drugs relieve symptoms in most people with schizophrenia, but up to ... Read more

Related support groups: Seroquel, Abilify, Schizophrenia, Latuda, Risperdal, Zyprexa, Risperidone, Schizoaffective Disorder, Geodon, Saphris, Seroquel XR, Quetiapine, Agitation, Psychosis, Olanzapine, Psychiatric Disorders, Invega, Clozapine, Aripiprazole, Rexulti

Beware Safety Risks Posed by 'Off-Label' Drug Use

Posted 2 Nov 2015 by Drugs.com

MONDAY, Nov. 2, 2015 – "Off-label" drug use puts patients at risk for serious side effects, especially when scientific evidence is lacking, a new study finds. Physicians prescribe "off-label" when they recommend drugs for uses that have not been approved by the U.S. Food and Drug Administration. It's a common and legal practice. It's also hard to track, because U.S. doctors aren't required to document the reason for prescribing a treatment. But in what may be the most extensive review of the practice to date, a Canadian-U.S. research team found reason for concern. Patients prescribed off-label drugs without strong scientific evidence were 54 percent more likely to experience an adverse event, such as a drug reaction, drug interaction or allergic response, forcing them to stop taking the drugs, the study found. "We are not saying that off-label is bad," said Dr. Tewodros Eguale, who led ... Read more

Related support groups: Migraine, Seroquel, Amitriptyline, Migraine Prevention, Risperdal, Elavil, Zyprexa, Risperidone, Seroquel XR, Quetiapine, Olanzapine, Migraine Prophylaxis, Quinine, Nocturnal Leg Cramps, Symbyax, Endep, Zyprexa Zydis, Risperdal Consta, Qualaquin, Triavil

Many Seniors Given Antipsychotic Meds, Despite Potential Problems

Posted 21 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 21, 2015 – Antipsychotic drug use in American seniors increases with age, a new study cautions. The researchers found that the percentage of people aged 80 to 84 who received a prescription for an antipsychotic drug was twice that of people aged 65 to 69. This increase is occurring despite the known risks of serious side effects such as stroke, kidney damage, and death, they added. "The results of the study suggest a need to focus on new ways to treat the underlying causes of agitation and confusion in the elderly," study author Dr. Mark Olfson, from the College of Physicians and Surgeons and Columbia University in New York City, said in a news release from the U.S. National Institute of Mental Health (NIMH). "The public health community needs to give greater attention to targeted environmental and behavioral treatments rather than medications," he added. The ... Read more

Related support groups: Seroquel, Abilify, Lithium, Latuda, Risperdal, Zyprexa, Risperidone, Geodon, Saphris, Seroquel XR, Quetiapine, Olanzapine, Haldol, Invega, Haloperidol, Clozapine, Compazine, Aripiprazole, Prochlorperazine, Perphenazine

Brain Inflammation May Be Linked to Schizophrenia

Posted 16 Oct 2015 by Drugs.com

FRIDAY, Oct. 15, 2015 – Researchers say they've found a link between brain inflammation and schizophrenia. British investigators used PET scans to assess immune cell activity in the brains of 56 people. Some had schizophrenia, some were at risk for the mental disorder, and others had no symptoms or risk of the disease. The results showed that immune cells are more active in the brains of people with schizophrenia and those at risk for the disease. "Our findings are particularly exciting because it was previously unknown whether these cells become active before or after onset of the disease," lead author Peter Bloomfield, of the Medical Research Council's Clinical Sciences Center at Imperial College London, said in a college news release. "Now we have shown this early involvement, mechanisms of the disease and new medications can hopefully be uncovered," he added. The findings could ... Read more

Related support groups: Seroquel, Abilify, Lithium, Schizophrenia, Latuda, Risperdal, Zyprexa, Risperidone, Schizoaffective Disorder, Geodon, Saphris, Seroquel XR, Quetiapine, Oppositional Defiant Disorder, Agitation, Psychosis, Olanzapine, Haldol, Agitated State, Invega

ERs Often 'Safety Net' Care for People With Schizophrenia: CDC

Posted 23 Sep 2015 by Drugs.com

WEDNESDAY, Sept. 23, 2015 – A new report finds that, too often, under-medicated Americans suffering from schizophrenia end up seeking care in the nation's hospital emergency rooms. The report, issued Wednesday by the U.S. Centers for Disease Control and Prevention, found that between 2009 and 2011, over 382,000 visits to ERs were recorded for people aged 18 to 64 with schizophrenia. Many of these cases involved people on Medicaid who were either homeless or living in places such as nursing homes or group homes, the researchers said. Emergency departments "may serve as a safety net for schizophrenic patients not otherwise receiving care," said Dr. Michael Albert and Linda McCaig, both of whom work at the CDC's National Center for Health Statistics (NCHS). Mental health expert Dr. Michael Birnbaum said the new findings were "not surprising." "Unfortunately many people with mental illness ... Read more

Related support groups: Seroquel, Abilify, Lithium, Schizophrenia, Latuda, Risperdal, Zyprexa, Risperidone, Schizoaffective Disorder, Geodon, Saphris, Seroquel XR, Quetiapine, Psychosis, Haldol, Olanzapine, Invega, Clozapine, Haloperidol, Compazine

Drug May Calm Agitation in Alzheimer's Patients

Posted 22 Sep 2015 by Drugs.com

TUESDAY, Sept. 22, 2015 – A drug that combines a cough suppressant with a heart medication might offer a safer option for calming the agitation that commonly affects people with Alzheimer's disease, an early clinical trial suggests. The study, of 220 Alzheimer's patients, found that the drug – called Nuedexta – generally eased agitation symptoms over 10 weeks. And it did not worsen patients' problems with memory, thinking and judgment, researchers reported in the Sept. 22/29 issue of the Journal of the American Medical Association. As Alzheimer's disease progresses, people often go through periods of agitation that can range from restlessness and pacing to aggressive behavior like yelling, fighting and destroying objects. If those issues can be managed without medication, that's always best, said Dr. Sam Gandy, a professor of neurology and psychiatry at Mount Sinai Hospital, in New ... Read more

Related support groups: Bipolar Disorder, Seroquel, Abilify, Schizophrenia, Latuda, Risperdal, Zyprexa, Risperidone, Schizoaffective Disorder, Geodon, Saphris, Seroquel XR, Quetiapine, Alzheimer's Disease, Agitation, Olanzapine, Agitated State, Invega, Clozapine, Aripiprazole

Antipsychotic Drugs Will Become More Affordable, Study Predicts

Posted 4 Sep 2015 by Drugs.com

FRIDAY, Sept. 4, 2015 – Patent expirations on several leading antipsychotic drugs could save Medicaid billions of dollars a year as the medications become available in cheaper generic versions, a new study finds. Patients covered by Medicaid – the publicly funded insurance program for the poor – account for 70 to 80 percent of all antipsychotic prescriptions in the United States, the researchers said. The lower costs of "second-generation" antipsychotics, such as Abilify and Seroquel, could prompt Medicaid to lift restrictions on access to the drugs, the study authors predicted. The drugs are used to treat mental illnesses such as schizophrenia and bipolar disorder. "Mental health medications are among the most prescribed drugs in Medicaid, and many of these medications have recently become available as generics or soon will be," said Eric Slade, an economist and associate professor ... Read more

Related support groups: Bipolar Disorder, Seroquel, Abilify, Schizophrenia, Zyprexa, Geodon, Seroquel XR, Quetiapine, Olanzapine, Invega, Aripiprazole, Zyprexa Zydis, Ziprasidone, Invega Sustenna, Paliperidone, Abilify Maintena, Abilify Discmelt, Zyprexa Intramuscular, Zyprexa Relprevv, Invega Trinza

Are Too Many Young Americans Getting Antipsychotics for ADHD?

Posted 1 Jul 2015 by Drugs.com

WEDNESDAY, July 1, 2015 – A growing number of teens and young adults are being prescribed powerful antipsychotics, even though the medications aren't approved to treat two disorders – ADHD and depression – they are commonly used for, a new study shows. Researchers found that antipsychotic use rose among children aged 13 and older – from 1.1 percent in 2006 to nearly 1.2 percent in 2010. And among young adults – people aged 19 to 24 – antipsychotic use increased from 0.69 percent in 2006 to 0.84 percent in 2010. Of concern to some experts are the conditions for which many of these antipsychotic prescriptions are being written, namely attention-deficit hyperactivity disorder (ADHD) and depression. Currently, the U.S. Food and Drug Administration approves this class of drugs for psychiatric conditions such as psychosis, bipolar disorder, schizophrenia or impulsive aggression tied to ... Read more

Related support groups: Depression, Seroquel, Abilify, Attention Deficit Hyperactivity Disorder (ADHD), Major Depressive Disorder, Lithium, Latuda, Risperdal, Zyprexa, Risperidone, Geodon, Saphris, Seroquel XR, Quetiapine, Oppositional Defiant Disorder, Olanzapine, Haldol, Invega, Dysthymia, Haloperidol

First Generic Abilify Approved

Posted 29 Apr 2015 by Drugs.com

WEDNESDAY, April 29, 2015 – The first generic versions of the atypical antipsychotic drug Abilify (aripiprazole) have been approved by the U.S. Food and Drug Administration to treat schizophrenia or bipolar disorder. License to produce the drug in multiple strengths was approved for Alembic Pharmaceuticals, Hetero Labs, Teva Pharmaceuticals, and Torrent Pharmaceuticals, the agency said in a news release. Bipolar disorder, also known as manic depression or manic-depressive illness, is a brain disorder that causes unusual moods and activities, affecting the ability to carry out day-to-day tasks. Symptoms typically include alternating periods of depression (lows) and increased activity and restlessness (highs). Schizophrenia, another brain disorder, affects about 1 percent of Americans. Symptoms typically begin in people younger than 30, and include hearing voices, believing other people ... Read more

Related support groups: Bipolar Disorder, Seroquel, Abilify, Schizophrenia, Mania, Latuda, Risperdal, Zyprexa, Risperidone, Schizoaffective Disorder, Geodon, Saphris, Seroquel XR, Quetiapine, Olanzapine, Invega, Clozapine, Aripiprazole, Clozaril, Fanapt

FDA Medwatch Alert: Zyprexa Relprevv (olanzapine pamoate): Drug Safety Communication - FDA Review of Study Sheds Light on Two Deaths Associated with the Injectable Schizophrenia Drug

Posted 23 Mar 2015 by Drugs.com

ISSUE: FDA has concluded a review of a study undertaken to determine the cause of elevated levels of the injectable schizophrenia drug Zyprexa Relprevv (olanzapine pamoate) in two patients who died. The study results were inconclusive. FDA is unable to exclude the possibility that the deaths were caused by rapid, but delayed, entry of the drug into the bloodstream following intramuscular injection. The study suggested that much of the drug level increase could have occurred after death, a finding that could explain the extremely high blood levels found in the two patients who died 3 to 4 days after receiving injections of appropriate doses of Zyprexa Relprevv. On the basis of all of the information reviewed (refer to the Drug Safety Communication for a full data summary), FDA is not recommending any changes to the current prescribing or use of Zyprexa Relprevv injection at this time. ... Read more

Related support groups: Schizophrenia, Zyprexa, Olanzapine, Zyprexa Relprevv

Medication Errors Occur Every 8 Minutes in U.S. Children

Posted 20 Oct 2014 by Drugs.com

MONDAY, Oct. 20, 2014 – A child receives the wrong medication or the wrong dosage every eight minutes in the United States, according to a recent study. Nearly 700,000 children under 6 years old experienced an out-of-hospital medication error between 2002 and 2012. Out of those episodes, one out of four children was under a year old. As the age of children decreased, the likelihood of an error increased, the study found. Though 94 percent of the mistakes didn't require medical treatment, the errors led to 25 deaths and about 1,900 critical care admissions, according to the study. "Even the most conscientious parents make errors," said lead author Dr. Huiyun Xiang, director of the Center for Pediatric Trauma Research at Nationwide Children's Hospital in Columbus, Ohio. That conscientiousness may even lead to one of the most common errors: Just over a quarter of these mistakes involved a ... Read more

Related support groups: Xanax, Klonopin, Clonazepam, Seroquel, Ativan, Valium, Abilify, Lorazepam, Alprazolam, Azithromycin, Soma, Diazepam, Benadryl, Flexeril, Cyclobenzaprine, Zyrtec, Latuda, Baclofen, Hydroxyzine, Risperdal

Certain Antipsychotic Meds Tied to Kidney Problems in Elderly

Posted 19 Aug 2014 by Drugs.com

TUESDAY, Aug. 19, 2014 – Kidney injury can be added to the list of possible harms related to use of three antipsychotic medications often prescribed to treat behavioral symptoms of dementia in older adults, a new study finds. Quetiapine (Seroquel), risperidone (Risperdal) and olanzapine (Zyprexa) are approved by the U.S. Food and Drug Administration to treat bipolar disorder, schizophrenia and other serious mental disorders. They are also frequently used "off-label" to treat behavioral concerns such as aggression or agitation in seniors with Alzheimer's and similar neurodegenerative diseases. "The side effect profile with antipsychotics is particularly concerning, so there is ample evidence to worry about their use in older adults unless they're absolutely necessary," said Dr. Anton Porsteinsson, director of Alzheimer's disease care, research and education at the University of ... Read more

Related support groups: Seroquel, Schizophrenia, Risperdal, Zyprexa, Risperidone, Seroquel XR, Quetiapine, Olanzapine, Zyprexa Zydis, Risperdal Consta, Risperdal M-Tab, Zyprexa Intramuscular, Zyprexa Relprevv

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