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Weight Gain From Antidepressants Is Minimal, Study Suggests

Posted 5 Jun 2014 by Drugs.com

THURSDAY, June 5, 2014 – While it has long been known that some antidepressants can help spur weight gain, a new study finds that the actual amount gained is usually small. "This study was motivated in the first place by the number of patients who have asked me if their medicine is going to make them gain weight," said study co-author Dr. Roy Perlis, director of Massachusetts General Hospital's Center for Experimental Drugs and Diagnostics, in Boston. "It's the most common question I get when prescribing any medication, frankly," he said. "But most antidepressant studies have been short term, looking at just a few months of treatment. So I wanted to look at it for a longer period of time," Perlis explained. "I think our findings should be reassuring to patients. Yes, antidepressants can lead in some cases to small amounts of weight gain, that's true. And we need to pay attention to it, ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Celexa, Paxil, Citalopram, Amitriptyline, Sertraline, Effexor XR, Bupropion, Fluoxetine, Venlafaxine, Wellbutrin XL, Mirtazapine, Remeron, Elavil

Drug Duo Might Help Smokers Quit Better Than Single Med

Posted 7 Jan 2014 by Drugs.com

TUESDAY, Jan. 7, 2014 – Two drugs in combination might be better than one when it comes to helping hardcore smokers quit, at least in the short term, a new study suggests. The drugs – varenicline (sold under the brand name Chantix) and bupropion (Zyban) – taken together increase the rates of quitting over 12 weeks compared with Chantix alone, the researchers found. After a year, however, relapse rates were similar using both approaches. "We believe this evidence strongly supports the idea that varenicline helps everybody quit," said lead researcher Dr. Jon Ebbert, a professor of medicine at the Mayo Clinic in Rochester, Minn. "But for heavier smokers and more dependent smokers, combination therapy with varenicline plus bupropion will increase quit rates more than varenicline alone." "This is how we are going to treat patients," he said. Combination therapy works better than a single ... Read more

Related support groups: Wellbutrin, Bupropion, Chantix, Wellbutrin XL, Smoking Cessation, Wellbutrin SR, Zyban, Budeprion, Aplenzin, Champix, Budeprion XL, Zyban Advantage Pack, Varenicline, Buproban, Budeprion SR

Psychiatric Drugs More Often Prescribed in the South

Posted 1 Feb 2013 by Drugs.com

FRIDAY, Feb. 1 – Use of psychiatric medications is most prevalent in the southern United States and least prevalent in the West, according to a new U.S. study. Although people living in the West are the least likely to use antipsychotics, antidepressants and stimulants, the Yale researchers found that the drugs' use is 40 percent higher in a large section of the South than in other parts of the country. The study authors attributed this discrepancy to variations in local access to health care and marketing efforts within the pharmaceutical industry. "The geographic patterns we identify are striking and map onto the patterns found for a host of other medical conditions and treatments, from cognitive decline to bypass surgery," Marissa King, assistant professor of organizational behavior at the Yale School of Management, said in a school news release. "Our work suggests that access to ... Read more

Related support groups: Depression, Bipolar Disorder, Adderall, Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Seroquel, Celexa, Paxil, Phentermine, Trazodone, Vyvanse, Abilify, Citalopram, Pristiq, Lithium, Viibryd

FDA Pulls One Generic Form of Wellbutrin Off the Market

Posted 5 Dec 2012 by Drugs.com

WEDNESDAY, Dec. 5 – People taking the antidepressant Wellbutrin now have one less option for a generic version of the drug. In October, the U.S. Food and Drug Administration recommended that generic Wellbutrin, or bupropion, made by Impax Laboratories and distributed by Teva Pharmaceuticals, be taken off the market, and Impax and Teva have agreed to stop shipping the drug. The decision is based on an FDA study that found that the extended release (XL) form of bupropion – Budeprion XL – at the 300 milligram (mg) dose was not bioequivalent to brand-name Wellbutrin XL at the same dose, suggesting that it may not be as safe and effective. The study was published Dec. 5 in the New England Journal of Medicine. Four other manufacturers make bupropion XL in 300 mg tablets, and patients can still get their prescription filled with these products. "The other four generic versions of 300 mg ... Read more

Related support groups: Wellbutrin, Bupropion, Wellbutrin XL, Wellbutrin SR, Zyban, Budeprion, Aplenzin, Budeprion XL, Zyban Advantage Pack, Buproban, Budeprion SR

FDA Update: Budeprion XL 300 mg Not Therapeutically Equivalent to Wellbutrin XL 300 mg

Posted 9 Oct 2012 by Drugs.com

October 3, 2012 – The U.S. Food and Drug Administration (FDA) has reviewed new data that indicate Budeprion XL 300 mg (bupropion hydrochloride extended-release tablets), manufactured by Impax Laboratories, Inc., and marketed by Teva Pharmaceuticals USA, Inc., is not therapeutically equivalent to Wellbutrin XL 300 mg. FDA has changed the therapeutic equivalence rating for this product in the Agency’s Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) from AB to BX, signifying that Budeprion XL 300 mg fails to demonstrate therapeutic equivalence to Wellbutrin XL 300 mg. Impax has requested that the Agency withdraw approval of budeprion XL 300 mg extended-release tablets. Impax and Teva have stopped shipping the product and are issuing detailed information to their customers. This announcement relates only to Budeprion XL 300 mg manufactured by Impax and m ... Read more

Related support groups: Wellbutrin, Bupropion, Wellbutrin XL, Wellbutrin SR, Zyban, Budeprion, Aplenzin, Budeprion XL, Zyban Advantage Pack, Buproban, Budeprion SR

Genes Might Help Some Smokers Kick the Habit

Posted 31 May 2012 by Drugs.com

THURSDAY, May 31 – Smokers' genes may help predict whether they'll respond to drug treatments for nicotine addiction, a new study indicates. Researchers analyzed data from more than 6,000 smokers in community-based studies and a clinical treatment study and found that the same gene variations that make it difficult to stop smoking also increase the chances that heavy smokers will respond to nicotine-replacement therapy and drugs that reduce the craving for nicotine. "People with the high-risk genetic markers smoked an average of two years longer than those without these high-risk genes, and they were less likely to quit smoking without medication," study first author Dr. Li-Shiun Chen, an assistant professor of psychiatry at Washington University of Medicine in St. Louis, said in a university news release. "The same gene variants can predict a person's response to smoking-cessation ... Read more

Related support groups: Wellbutrin, Smoking, Bupropion, Wellbutrin XL, Smoking Cessation, Wellbutrin SR, Nicotine, Zyban, Nicorette, Nicoderm CQ, Nicotrol Inhaler, Budeprion, Aplenzin, Commit, Budeprion XL, Zyban Advantage Pack, Buproban, Habitrol, Budeprion SR, Nicorelief

Minorities, Medicare Recipients Less Likely to Get Antidepressants

Posted 9 Apr 2012 by Drugs.com

MONDAY, April 9 – Hispanics and blacks are less likely to be prescribed antidepressants than whites, and Medicare and Medicaid patients are less likely to receive the drugs than those with private insurance, a new study says. University of Michigan School of Public Health researchers examined data from 1993 to 2007 and found that whites were 1.5 times more likely to receive antidepressants than blacks or Hispanics with major depression. The study also found that Medicare and Medicaid patients were 31 percent and 38 percent less likely to be prescribed antidepressants than privately insured patients. Race didn't play a role in the type of antidepressants prescribed to patients, but insurance did. Medicare and Medicaid patients were 58 percent and 61 percent less likely to receive newer antidepressants than privately insured patients. Newer types of antidepressants such as serotonin ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Celexa, Paxil, Trazodone, Citalopram, Pristiq, Viibryd, Amitriptyline, Sertraline, Effexor XR, Bupropion, Fluoxetine, Venlafaxine, Savella

Prescription Meds Can Put on Unwanted Pounds

Posted 2 Mar 2012 by Drugs.com

FRIDAY, March 2 – Medications taken by millions of Americans for mood disorders, high blood pressure, diabetes and other chronic conditions can have an unhealthy side effect: weight gain. While other choices exist for some types of drugs, adjusting medications is not simply a matter of switching, said Ryan Roux, chief pharmacy officer with the Harris County Hospital District, in Houston. In the late 1990s, Dr. Lawrence Cheskin conducted early research on prescription medicines and obesity. "Some medicines make an early, noticeable difference, causing patients to become ravenously hungry, while changes are subtle for others. A few months taking them and you've gained 10 pounds," said Cheskin, now director of the Johns Hopkins Weight Management Center, in Baltimore. To help increase awareness, Roux and his pharmacist group have compiled a list of "weight-promoting" and "weight-neutral or ... Read more

Related support groups: Bipolar Disorder, High Blood Pressure, Zoloft, Diabetes, Type 2, Wellbutrin, Plan B, Prozac, Prednisone, Gabapentin, Seroquel, Metformin, Hypertension, Sprintec, Paxil, Lamictal, Mirena, Implanon, Provera, Metoprolol, Neurontin

Best Antidepressant May Depend on Patient: Study

Posted 5 Dec 2011 by Drugs.com

TBD – Newer antidepressants seem to be about as effective as one another, a new analysis indicates. This suggests that the choice of which drug is appropriate for which patient should be made on the basis of such considerations as side effects, cost and patient preference. "They're all equally effective," said Dr. David Schlager, a clinical assistant professor of psychiatry and behavioral science at Texas A&M Health Science Center College of Medicine. "They're interchangeable except for side effects," he added, so psychiatrists do tend to "exploit the side-effect profile" to find suitable medications for individual patients, he added. According to the background information in the new study, appearing in the Dec. 6 issue of Annals of Internal Medicine, some 27 million people in the United States had taken antidepressants as of 2005. Most of these drugs are "second-generation" ... Read more

Related support groups: Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Celexa, Paxil, Citalopram, Pristiq, Sertraline, Effexor XR, Bupropion, Fluoxetine, Venlafaxine, Savella, Wellbutrin XL, Wellbutrin SR, Escitalopram, Paroxetine

Patches, Counseling, Persistence Can Help Smokers Quit

Posted 28 Nov 2011 by Drugs.com

MONDAY, Nov. 28 – Quitting smoking isn't easy for most people but medication and counseling can help them succeed, according to the results of two new studies. In the first of the two reports published in the Nov. 28 issue of the Archives of Internal Medicine, a team led by Dr. Anne Joseph, co-leader of the Prevention & Etiology Research Program at the Masonic Cancer Center at the University of Minnesota, tried helping people by keeping in touch with them and reminding them to quit smoking. "We looked at a model that treated smoking as a chronic condition like high blood pressure or diabetes," Joseph said. "We know that using a combination of behavioral therapy and medication therapy, people do better than quitting on their own," she said. For the study, more than 400 smokers received counseling over the phone along with nicotine replacement therapy (such as patches, gums, lozenges) ... Read more

Related support groups: Wellbutrin, Smoking, Bupropion, Chantix, Wellbutrin XL, Smoking Cessation, Wellbutrin SR, Nicotine, Zyban, Nicorette, Nicoderm CQ, Nicotrol Inhaler, Budeprion, Aplenzin, Champix, Commit, Budeprion XL, Zyban Advantage Pack, Varenicline, Buproban

Smokeout Day: The Best Ways to Quit

Posted 16 Nov 2011 by Drugs.com

WEDNESDAY, Nov. 16 – As thousands of smokers across the United States try to kick their bad habit as part of the Great American Smokeout on Thursday, experts agree that a two-pronged strategy is the best bet for success. "The U.S. Public Health Service has twice done very extensive reviews of all the evidence, and [best] is a combination of counseling/advice, by pharmacists, physicians or quitlines, plus medicine," said Thomas Glynn, director of cancer science and trends and of international cancer control for the American Cancer Society. A lot has changed since 1976, when the first smokeout took place, Glynn noted. "People could smoke on airplanes and in restaurants; the person sitting next to you in the movie theater could be smoking. Two of every five people smoked; now it's one of five." Another difference: "Now, there are a number of ways that people can succeed, [including] seven ... Read more

Related support groups: Wellbutrin, Smoking, Bupropion, Chantix, Wellbutrin XL, Smoking Cessation, Wellbutrin SR, Zyban, Budeprion, Aplenzin, Champix, Budeprion XL, Zyban Advantage Pack, Varenicline, Buproban, Budeprion SR

Fear of Antidepressants Keep Many From Disclosing Depression

Posted 13 Sep 2011 by Drugs.com

TUESDAY, Sept. 13 – For a nation that seems ready to pop a pill for any ill, a new study suggests that the opposite seems true for some people with symptoms of depression, whose concerns about the side effects of antidepressants were the top reason they wouldn't disclose warning signs to their doctors. A phone survey of more than 1,000 adults who had previously participated in the California Behavioral Risk Factor Survey System, which probed depression-related beliefs, showed that 43 percent reported one or more reasons for not talking to their primary care physician about their depression. Nearly a quarter of them worried that their doctor would recommend antidepressants – the most frequently cited reason for withholding the information. Other stated barriers to sharing depressive symptoms included the belief that it's not a primary care physician's job to deal with emotional issues ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Celexa, Paxil, Trazodone, Citalopram, Pristiq, Viibryd, Amitriptyline, Sertraline, Effexor XR, Bupropion, Fluoxetine, Venlafaxine, Savella

Certain Antidepressants Linked to Falls in Nursing Homes

Posted 26 Jul 2011 by Drugs.com

TUESDAY, July 26 – In the days after they start taking non-SSRI (selective serotonin reuptake inhibitor) antidepressants, such as bupropion or venlafaxine, nursing home residents are at significantly greater risk for falls, according to a new study. Researchers found the increased risk for falls also applies to those who had a dosage increase of their current prescription. "Our results identify the days following a new prescription or increased dose of a non-SSRI antidepressant as a window of time associated with a particularly high risk of falling among nursing home residents," said study author Dr. Sarah D. Berry, a scientist at the Institute for Aging Research of Hebrew SeniorLife in Boston. More closely monitoring these nursing home residents for two days after a change in these antidepressants could help prevent falls, the researchers said. In conducting the study, recently ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Celexa, Paxil, Citalopram, Pristiq, Sertraline, Effexor XR, Bupropion, Fluoxetine, Venlafaxine, Savella, Wellbutrin XL, Wellbutrin SR, Escitalopram

Studies Decipher How Anti-Smoking Drugs Work

Posted 3 Jan 2011 by Drugs.com

MONDAY, Jan.3 – Two drugs that help people stop smoking – bupropion and varenicline – may change the way the brain reacts to seeing someone else smoke, new studies report. And that may be how they cut cravings. Bupropion (Wellbutrin, Zyban) is prescribed around the world to help people resist smoking cues. But it has not been clear how the drug does this. Using brain scans, Christopher S. Culbertson, of the University of California, Los Angeles, and his colleagues examined what happened in the brains of 30 smokers who took the drug or a placebo for eight weeks. The researchers gauged how much the participants craved cigarettes by asking them to respond after watching "neutral" cues that did not involve smoking or 45-second videos of actors and actresses smoking. Those who took the drug instead of the placebo reported less craving. They also showed less activity in areas of the brain ... Read more

Related support groups: Wellbutrin, Bupropion, Chantix, Wellbutrin XL, Smoking Cessation, Wellbutrin SR, Zyban, Budeprion, Aplenzin, Champix, Budeprion XL, Zyban Advantage Pack, Varenicline, Budeprion SR

Antidepressant Use Rising as Psychotherapy Rates Fall

Posted 6 Dec 2010 by Drugs.com

MONDAY, Dec. 6 – Even as fewer Americans have sought psychotherapy for their depression, antidepressant prescription rates have continued to climb in recent years, a new survey reveals. "This is an encouraging trend as it suggests that fewer depressed Americans are going without treatment," said study author Dr. Mark Olfson, a professor of clinical psychiatry at Columbia University/New York State Psychiatric Institute in New York City. "At the same time, however, the decline in psychotherapy raises the possibility that many depressed patients are not receiving optimal care." "While progress is being made in increasing the availability of depression care, a mismatch is opening up between clinical evidence and practice," Olfson cautioned. "For many depressed adults and youth, a combination of psychotherapy and antidepressants is the most effective approach. Yet, only about one-third of ... Read more

Related support groups: Depression, Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Celexa, Paxil, Trazodone, Citalopram, Pristiq, Amitriptyline, Sertraline, Effexor XR, Bupropion, Fluoxetine, Venlafaxine, Savella, Wellbutrin XL

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