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FDA Approves Targiniq ER Hard-to-Abuse Narcotic Painkiller

Posted 6 days ago by Drugs.com

THURSDAY, July 24, 2014 – A new formulation of a powerful narcotic painkiller that discourages potential abusers from snorting or injecting the drug has been approved by the U.S. Food and Drug Administration. Called Targiniq ER and made by Purdue Pharma, the pill is a combination of the narcotic oxycodone and naloxone, a drug that blocks the euphoric effects of oxycodone. The naloxone is only activated when the pill is crushed, snorted, dissolved or injected, according to the FDA. While Targiniq has only been approved for patients who have chronic pain that has not responded to other medications, the FDA acknowledged the medication can still be abused simply by taking too many pills. Currently, that is the most common way oxycodone is misused. Experts made the same point. "When the pills are swallowed they are as addictive and dangerous as pure oxycodone," Andrew Kolodny, chief medical ... Read more

Related support groups: Pain, Oxycodone

Targiniq ER Tough-to-Abuse Formulation of Oxycodone Approved

Posted 6 days ago by Drugs.com

THURSDAY, July 24, 2014 – Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended release) has been approved by the U.S. Food and Drug Administration as a long-term, around-the-clock treatment for severe pain when other therapies are ineffective or unavailable. The long-acting form of oxycodone, an opioid painkiller, has properties that are designed to deter abuse of the drug by snorting or injection, the FDA said in a news release. Targiniq contains naloxone, designed to block the euphoric effects of oxycodone, the agency said. Targiniq can still be abused by taking too many pills, the FDA warned, stressing that an overdose could cause death. The drug is not meant for as-needed pain relief, the agency said, repeating its warning of the potential for abuse and addiction. Targiniq ER was evaluated in a clinical study of 601 people with chronic lower back pain. The most ... Read more

Related support groups: Pain, Suboxone, Oxycodone, Percocet, OxyContin, Roxicodone, Endocet, Percocet 10/325, Roxicet, Naloxone, Talwin Nx, Narcan, Acetaminophen/Oxycodone, Percocet 5/325, Percodan, OxyIR, Oxyfast, Percocet 7.5/325, Naloxone/Pentazocine, Percocet 10/650

FDA Approves Targiniq ER Extended-Release Oxycodone with Abuse-Deterrent Properties

Posted 8 days ago by Drugs.com

July 23, 2014 – Today, the U.S. Food and Drug Administration approved Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended-release tablets), an extended-release/long-acting (ER/LA) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Targiniq ER is the second ER/LA opioid analgesic with FDA-approved labeling describing the product’s abuse-deterrent properties consistentwith the FDA’s 2013 draft guidance for industry, Abuse-Deterrent Opioids – Evaluation and Labeling. Targiniq ER has properties that are expected to deter, but not totally prevent, abuse of the drug by snorting and injection. When crushed and snorted, or crushed, dissolved and injected, the naloxone in Targiniq ER blocks the euphoric effects of oxycodone, making it less liked by abusers th ... Read more

Related support groups: Pain, Oxycodone, Chronic Pain, Severe Pain, Naloxone

Popping Pills in America: Can the DEA Fix This?

Posted 17 days ago by Drugs.com

There's no doubt about it - the U.S. is a big consumer of prescription painkillers. In fact, in 2010 enough prescription painkillers were prescribed to medicate each American adult every four hours for an entire month. A report released in March 2014 from the U.S. National Safety Council shows that prescription drug overdoses – more than car accidents – are the leading cause of accidental death among U.S. working-age adults. According to the Centers for Disease Control and Prevention (CDC), one person dies every 19 minutes from a prescription drug overdose, fueled mainly by opioids. The narcotic abuse epidemic has gotten out of control. But what is being done to stop it? The Drug Enforcement Agency (DEA) is taking action. The medical community awaits a final DEA decision on switching hydrocodone combination products like Lortab and Vicodin from schedule III to schedule II to help curb ab ... Read more

Related support groups: Oxycodone, Percocet, Hydrocodone, OxyContin, Vicodin, Opiate Dependence, Norco, Lortab, Roxicodone, Endocet, Hydromet, Vicoprofen, Acetaminophen/Hydrocodone, Tussionex Pennkinetic, Percocet 10/325, Roxicet, Lorcet 10/650, Vicodin ES, Hycodan, Acetaminophen/Oxycodone

Prescriptions for Powerful Painkillers Vary Widely Among States: CDC

Posted 1 Jul 2014 by Drugs.com

TUESDAY, July 1, 2014 – Doctors in some states seem to wield a freer hand issuing prescriptions for powerful narcotic medications, leading to wide variations in narcotic drug use among states, U.S. health officials reported Tuesday. Physicians in Alabama – the state with the highest number of narcotic painkiller prescriptions – issued nearly three times as many of those prescriptions as doctors in Hawaii – the lowest prescribing state, according to researchers with the Centers for Disease Control and Prevention. "The bottom line is we're not seeing consistent, effective, appropriate prescribing of painkillers across the nation, and this is a problem because of the deaths that result," Dr. Tom Frieden, director of the CDC, said at a news conference. Frieden added that every day 46 people die from an overdose of prescription painkillers. Overall, health-care providers wrote 259 ... Read more

Related support groups: Pain, Suboxone, Oxycodone, Tramadol, Methadone, Percocet, Hydrocodone, OxyContin, Vicodin, Morphine, Norco, Fentanyl, Lortab, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta

Many U.S. Vets Suffer Chronic Pain, Take Narcotic Painkillers: Study

Posted 30 Jun 2014 by Drugs.com

MONDAY, June 30, 2014 – Nearly half of U.S. soldiers returning home are caught in the grip of chronic pain, with a substantial number of them relying on addictive narcotic painkillers to help them cope, a new study finds. About 44 percent of the members of an Army infantry brigade reported chronic pain even three months after returning from their tour of duty in Afghanistan or Iraq, nearly double the estimate for the civilian population. Civilian chronic pain rates are about 26 percent. Soldiers also are nearly four times more likely than civilians to use prescription narcotics to treat their pain, according to the report published online June 30 in the journal JAMA Internal Medicine. About 15 percent of soldiers in the brigade reported using narcotic painkillers within the last month, compared to 4 percent of civilians. "War is really hard on the body," said study author Lt. Cmdr. ... Read more

Related support groups: Suboxone, Oxycodone, Tramadol, Methadone, Percocet, Hydrocodone, OxyContin, Vicodin, Morphine, Norco, Fentanyl, Lortab, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta, Roxicodone

Use Prescription Painkillers Safely

Posted 8 Jun 2014 by Drugs.com

FRIDAY, June 6, 2014 – Powerful prescription painkillers known as opioids are often involved in accidental overdoses, so experts offer tips on how to take these highly addictive medications safely. "Prescription painkiller misuse is a growing epidemic. However, most people who abuse these drugs are struggling with an addiction they never intended to have," said John Ulczycki, vice president of strategic initiatives at the National Safety Council. "This National Safety Month, we hope to educate Americans on proper use so they can relieve pain without the tragic consequences of drug dependence or death." Dr. Don Teater, a medical advisor at the National Safety Council provided the following five tips to help ensure the safe use of prescription painkillers: Consider other options. Talk to your doctor about other medications that may be more effective in controlling your pain. In most ... Read more

Related support groups: Pain, Oxycodone, Tramadol, Methadone, Hydrocodone, OxyContin, Morphine, Fentanyl, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta, Roxicodone, MS Contin, Butrans, Hydromorphone, Buprenorphine

FDA Approves Quick-Acting Drug to Reverse Prescription Painkiller ODs

Posted 3 Apr 2014 by Drugs.com

THURSDAY, April 3, 2014 – The first prescription treatment that can be used by family members or caregivers to treat an overdose of narcotic painkillers has been approved by the U.S. Food and Drug Administration. Evzio is a hand-held auto injector that delivers a single dose of the drug naloxone into the muscle or beneath the skin. The injector can be carried in a pocket or stored in a medicine cabinet and is meant as an emergency treatment for people who have suffered a known or suspected overdose of powerful pain drugs called opioids. Opioids include prescription narcotic painkillers such as Oxycontin, Vicodin and Percocet – all of which have shown increasing rates of abuse in recent years. "Tragically, the most recent data shows that more than 16,000 lives are lost each year due to opioid-related overdoses," FDA Commissioner Margaret Hamburg said in an agency statement. "In fact, ... Read more

Related support groups: Oxycodone, OxyContin, Morphine, Heroin, Naloxone, Opioid Overdose

FDA Approves Evzio (naloxone) Hand-Held Auto-Injector to Reverse Opioid Overdose

Posted 3 Apr 2014 by Drugs.com

April 3, 2014 – The U.S. Food and Drug Administration today approved a prescription treatment that can be used by family members or caregivers to treat a person known or suspected to have had an opioid overdose. Evzio (naloxone hydrochloride injection) rapidly delivers a single dose of the drug naloxone via a hand-held auto-injector that can be carried in a pocket or stored in a medicine cabinet. It is intended for the emergency treatment of known or suspected opioid overdose, characterized by decreased breathing or heart rates, or loss of consciousness. Drug overdose deaths, driven largely by prescription drug overdose deaths, are now the leading cause of injury death in the United States – surpassing motor vehicle crashes. In 2013, the Centers for Disease Control and Prevention reported the number of drug overdose deaths had steadily increased for more than a decade. Naloxone is a ... Read more

Related support groups: Oxycodone, OxyContin, Morphine, Narcotic, Heroin, Naloxone

More ERs Treating Headaches With Narcotics, Study Finds

Posted 2 Apr 2014 by Drugs.com

WEDNESDAY, April 2, 2014 – There's been a big increase in prescriptions for powerful narcotic painkillers given to headache patients at hospital emergency departments, a new U.S. study finds. This increase has occurred even though guidelines from a number of medical groups, including the American Academy of Neurology and the American College of Emergency Physicians, say these pain drugs should not be used as a first-line treatment for headache. The study authors pointed out that this trend in emergency department prescribing practices has occurred at the same time that rates of abuse, overdose and deaths due to narcotics are on the rise in the United States. The researchers analyzed national data from 2001 to 2010 and found a 65 percent increase in emergency department use of narcotic prescriptions for headaches during that period. The largest rise (450 percent) was in the use of ... Read more

Related support groups: Suboxone, Oxycodone, Tramadol, Methadone, Percocet, Hydrocodone, OxyContin, Vicodin, Morphine, Norco, Fentanyl, Lortab, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta, Roxicodone

ERs Dispensing More Narcotic Painkillers: Study

Posted 23 Mar 2014 by Drugs.com

FRIDAY, March 21, 2014 – More and more Americans are being prescribed powerful narcotic drugs when they visit the emergency department for problems such as low back pain or a pounding headache, a new study finds. Between 2001 and 2010, emergency departments in the United States showed a 49 percent increase in prescriptions for narcotic painkillers – also known as opiates. That was despite the fact that there was only a small increase in the percentage of visits for painful conditions. Experts said the trend is concerning because narcotic painkillers – which include drugs like OxyContin, Percocet and Vicodin – can be addictive, or abused by people with existing drug problems. And while the drugs may be necessary for more-severe pain, ER doctors see many patients who can stick with over-the-counter pain relievers. "In many cases, naproxen, Tylenol (acetaminophen) and ibuprofen are the ... Read more

Related support groups: Pain, Suboxone, Oxycodone, Tramadol, Methadone, Percocet, Hydrocodone, OxyContin, Vicodin, Morphine, Norco, Fentanyl, Lortab, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta

FDA Approves Xartemis XR (oxycodone hydrochloride and acetaminophen) Extended-Release Tablets (CII)

Posted 12 Mar 2014 by Drugs.com

DUBLIN--(BUSINESS WIRE)--Mar. 12, 2014-- Mallinckrodt plc today announced that the U.S. Food and Drug Administration (FDA) has approved Xartemis XR (oxycodone hydrochloride and acetaminophen) Extended-Release Tablets (CII), previously known as MNK-795, for the management of acute pain severe enough to require opioid treatment and in patients for whom alternative treatment options (e.g., non-opioid analgesics) are ineffective, not tolerated or would otherwise be inadequate. Xartemis XR is the first and only extended-release oral combination of two clinically proven pain medications – oxycodone and acetaminophen. Xartemis XR has both immediate- and extended-release components: formulated to provide onset of pain relief in less than one hour and to allow twice daily dosing. The product’s release profile combines Mallinckrodt’s newly patented technology, including design, formulation, pha ... Read more

Related support groups: Pain, Oxycodone, Acetaminophen/Oxycodone

Study Finds 1 in 3 Tennesseans Uses Narcotic Painkillers Each Year

Posted 3 Mar 2014 by Drugs.com

MONDAY, March 3, 2014 – One of every three Tennesseans fills a prescription for narcotic painkillers at least once a year, creating a free-floating pool of available medication that helps feed the state's growing problem with prescription drug abuse, a new study has found. Nearly 5.2 million Tennessee residents received painkillers – 37 million total prescriptions – between 2007 and 2011, which works out to about 1.4 prescriptions per resident, according to a report published online March 3 in the journal JAMA Internal Medicine. A small but significant percentage of those residents appeared to be engaging in "doctor shopping," which indicates drug abuse and increases their risk of overdose death, said senior study author Dr. Timothy Jones, state epidemiologist for the Tennessee Department of Health. Among patients who received narcotic pain killers in 2011, 7.6 percent got ... Read more

Related support groups: Suboxone, Oxycodone, Tramadol, Methadone, Percocet, Hydrocodone, OxyContin, Vicodin, Morphine, Norco, Fentanyl, Lortab, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta, Roxicodone

Many U.S. Seniors Get Prescription Painkillers From Multiple Doctors

Posted 19 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 19, 2014 – About one-third of Medicare patients who get prescriptions for powerful narcotic painkillers receive them from multiple doctors, which raises their risk for hospitalization, according to a new study. Narcotics (also called opioids) include painkillers such as hydrocodone (Vicodin), oxycodone (Oxycontin) and morphine. Prescriptions for these drugs have risen sharply in the United States in the past 20 years – as have overdoses. "As physicians, we tell patients not to drive when they take opioids, but we also need to tell them that it can be dangerous to receive these medications from more than one provider," said study author Dr. Anupam Jena, an assistant professor of health care policy at Harvard Medical School. Jena and his colleagues also found that having multiple doctors prescribe prescription painkillers increased patients' risk of being hospitalized ... Read more

Related support groups: Suboxone, Oxycodone, Tramadol, Methadone, Percocet, Hydrocodone, OxyContin, Vicodin, Morphine, Norco, Fentanyl, Lortab, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta, Roxicodone

U.S. Officials Target Escalating Drug Overdoses

Posted 11 Feb 2014 by Drugs.com

TUESDAY, Feb. 11 – As deaths from heroin and prescription painkillers mount across the United States, government officials are searching for ways to stem the toll of addiction. The death last week of Oscar-winning actor Philip Seymour Hoffman, 46, in New York City from an apparent heroin overdose highlighted this escalating problem. "The use of opioids – a group of drugs that includes heroin and prescription painkillers – is having a devastating impact on public health and safety in communities across the nation," Gil Kerlikowske, director of the U.S. Office of National Drug Control Policy, said during a Tuesday morning news conference in Washington, D.C. "In 2010, approximately 100 Americans died from overdoses every day," Kerlikowske said. Prescription painkillers were involved in more than 16,600 deaths that year, and heroin was involved in about 3,000 deaths, he added. Overdose ... Read more

Related support groups: Suboxone, Oxycodone, Tramadol, Methadone, Percocet, Hydrocodone, OxyContin, Vicodin, Morphine, Norco, Fentanyl, Lortab, Codeine, Opana, Subutex, Dilaudid, Ultram, Opana ER, Nucynta, Roxicodone

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