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Osteoporosis Blog

Related terms: Bone Thinning

Osteoporosis Drugs Work, But Review Finds No Clear Winner

Posted 8 days ago by Drugs.com

MONDAY, Sept. 8, 2014 – Many osteoporosis drugs cut women's risk of suffering a bone fracture, though it's not clear whether any one medication works better than others, a new research review finds. Reporting Sept. 8 in Annals of Internal Medicine, researchers said that for women with the bone-thinning disease osteoporosis, various drugs cut the risk of a spine fracture by 40 to 60 percent, compared to a placebo. When it comes to other bone breaks, including hip fractures, the drugs lower the risk by 20 to 40 percent, the study said. The beneficial drugs included bisphosphonates, sold under brand names such as Actonel (risedronate), Boniva (ibandronate) and Fosamax (alendronate), and the injection drugs denosumab (Prolia) and teriparatide (Forteo). Meanwhile, raloxifene (Evista) – a daily pill that has estrogen-like effects on bones – seems to cut the risk of spine fractures only, ... Read more

Related support groups: Osteoporosis, Fosamax, Forteo, Boniva, Alendronate, Reclast, Prolia, Evista, Actonel, Prevention of Osteoporosis, Fracture, bone, Zometa, Aclasta, Xgeva, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Raloxifene

More Evidence Ties Some Bone-Building Drugs to Rare Fractures

Posted 13 days ago by Drugs.com

THURSDAY, Sept. 4, 2014 – Taking osteoporosis drugs called bisphosphonates to help prevent fractures may carry a slight risk for unusual breaks in the thigh bone, Swedish researchers report. For those who took bisphosphonates for four to five years, the so-called "relative risk" was 100 times higher than among people who didn't use the medications. But the researchers explained that the absolute risk of having such a fracture was small, and would affect only one in 1,000 people. "If you have osteoporosis, the benefit of bisphosphonates outweighs the risk during the first years of treatment. But if you don't have osteoporosis, but only a moderate decrease in bone density, the benefit is likely to be smaller than the risk," said lead researcher Dr. Per Aspenberg, a professor of orthopaedic surgery at Linkoping University in Sweden. However, U.S. experts said bisphosphonates still have a ... Read more

Related support groups: Osteoporosis, Fosamax, Boniva, Alendronate, Reclast, Actonel, Prevention of Osteoporosis, Fracture, bone, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Skelid, Etidronate, Fosamax Plus D, Actonel with Calcium

Bone Drugs Don't Lower Breast Cancer Risk After All, Study Finds

Posted 11 Aug 2014 by Drugs.com

MONDAY, Aug. 11 – Drugs known as bisphosphonates, commonly prescribed to treat the bone-weakening disease osteoporosis, don't appear to reduce the risk of breast cancer as previously thought, new research finds. "We found that postmenopausal women who took a bisphosphonate for three or four years did not have a decreased risk in breast cancer," said study author Trisha Hue, an epidemiologist at the University of California, San Francisco. When prior observational studies noted links between the drugs' use and lower breast cancer risk in, experts assumed the drugs deserved the credit. However, based on the new findings, Hue suspects that low estrogen levels may have been the risk-reducer. "Women who get bisphosphonates have a low bone mass density," she said. "If you have low bone mass density, you probably have low estrogen." This is because the hormone, which is depleted after ... Read more

Related support groups: Breast Cancer, Osteoporosis, Fosamax, Boniva, Alendronate, Reclast, Actonel, Prevention of Osteoporosis, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Binosto, Fosamax Plus D

Novel Osteoporosis Drug Could Change Treatment: Study

Posted 2 Jan 2014 by Drugs.com

THURSDAY, Jan. 2, 2014 – A new medication for osteoporosis prompts the body to rebuild bone and could potentially strengthen the skeleton against fractures, researchers report. The experimental drug, romosozumab, frees the body's ability to stimulate bone production by blocking biochemical signals that naturally inhibit bone formation, explained Dr. Michael McClung, founding director of the Oregon Osteoporosis Center in Portland, Ore. The treatment is one-and-a-half to three times more effective than current osteoporosis drugs in rebuilding bone density at the lumbar spine, according to clinical trial results McClung and his colleagues reported in the Jan.1 online edition of the New England Journal of Medicine. "Most osteoporosis drugs work by stopping the progression of bone loss, but they don't have the capability of rebuilding the skeleton," McClung said. "This really is a new day ... Read more

Related support groups: Osteoporosis

Ladies, Take 5 Steps to Avoid Osteoporosis

Posted 18 Oct 2013 by Drugs.com

FRIDAY, Oct. 18 – As the population ages, experts expect the number of women with the bone-thinning disease osteoporosis to surge. "Osteoporosis is a serious threat to women's health – worldwide one in three women over the age of 50 will suffer a broken bone due to osteoporosis," John Kanis, president of the International Osteoporosis Foundation, said in a foundation news release. "Yet too many women are unaware of their increased risk after menopause and fail to take preventive measures." Once they reach menopause, women's risk for osteoporosis increases as bone loss accelerates and bones weaken. Women older than 45 spend more time in the hospital because of osteoporosis than any other chronic disease, including diabetes, heart attack or breast cancer, according to the news release. Fractures because of osteoporosis often lead to immobility, diminished quality of life and early ... Read more

Related support groups: Osteoporosis, Prevention of Osteoporosis

No Sign That Vitamin D Supplements Help Aging Bones: Study

Posted 11 Oct 2013 by Drugs.com

THURSDAY, Oct. 10 – Taking vitamin D supplements does not prevent the bone weakening of osteoporosis in healthy adults, a new review finds. Nearly half of people aged 50 and older use vitamin D supplements, but these findings suggest that there is no need for healthy adults to take these supplements to combat osteoporosis. Instead, the use of these supplements should be focused only on people who are likely to be vitamin D deficient, the New Zealand researchers said. One expert in the United States agreed with that advice. "The review supports previous studies that found that vitamin D alone is not preventative in healthy adults," said Victoria Richards, an assistant professor of medical sciences at the Netter School of Medicine at Quinnipiac University in Hamden, Conn. "From this study, consumers may no longer feel the need to continue purchasing vitamin D supplements for the ... Read more

Related support groups: Osteoporosis, Vitamin D Deficiency, Vitamin D Insufficiency

Little Benefit Seen in Repeat Bone-Density Testing

Posted 24 Sep 2013 by Drugs.com

TUESDAY, Sept. 24 – For many seniors, it may not be worthwhile to undergo frequent imaging tests to see if they're at risk for broken bones, a new study suggests. Repeating a bone-mineral-density test four years after the initial one did not provide substantially more information to predict fracture risk among older men and women who did not yet have osteoporosis, the study found. "We found that the initial bone-density test did a good job of identifying individuals at risk for a fracture," said Dr. Sarah D. Berry, a research scientist at the Institute for Aging Research at Hebrew Senior Life and an assistant professor of medicine at Harvard Medical School in Boston. The bone-mineral-density DEXA test often is repeated every two years, Berry said, as Medicare part B will reimburse for it every two years, and more often if medically necessary. DEXA stands for dual energy X-ray ... Read more

Related support groups: Osteoporosis, Prevention of Osteoporosis, Fracture, bone, Diagnosis and Investigation, Prevention of Fractures

Vitamin D Alone Doesn't Boost Bone Health, Study Says

Posted 24 Sep 2013 by Drugs.com

TUESDAY, Sept. 24 – Calcium supplements improve bone health in postmenopausal women, but vitamin D supplements provide no benefit in women with normal vitamin D levels, a new study finds. "These findings suggest that vitamin D supplements over the recommended dietary allowance do not protect bone health, whereas calcium supplements do have an effect," study lead author Dr. John Aloia, of Winthrop University Hospital in Mineola, N.Y., said in a news release from the Endocrine Society. For the study, published Sept. 24 in the Journal of Clinical Endocrinology & Metabolism, the researchers examined bone turnover in 159 postmenopausal women. Bone turnover is the body's natural process for breaking down old bone. Young people produce enough new bone to replace what is lost, but bone mass in women begins to decline after age 30, and this loss speeds up after menopause. The women in the study ... Read more

Related support groups: Osteoporosis, Vitamin D, Vitamin D3, Prevention of Osteoporosis, D3, Cholecalciferol, Ergocalciferol, Drisdol, Caltrate 600 with D, Hectorol, Os-Cal 500 with D, Calcium/Vitamin D, Replesta, Oysco 500 with D, Citracal + D, Calcet, Oyster Shell Calcium, Delta D3, Doxercalciferol, Calcium 600 D

Bone Marrow Fat May Raise Osteoporosis Risk, Study Says

Posted 16 Jul 2013 by Drugs.com

TUESDAY, July 16 – Excess fat in blood, muscle and the liver may increase the risk of osteoporosis, a new study suggests. Researchers measured fat in more than 100 men and women, ageD 19 to 45, who were obese but otherwise healthy. Those with more liver and muscle fat had higher levels of fat in their bone marrow, the study found. Higher levels of bone marrow fat put people at increased risk of fractures, according to the authors of the study published online July 16 in the journal Radiology. "Bone marrow fat makes bones weak. If you have a spine that's filled with fat, it's not going to be as strong," study lead author Dr. Miriam Bredella, a radiologist at Massachusetts General Hospital and associate professor of radiology at Harvard Medical School in Boston, said in a journal news release. She and her colleagues also found that people with elevated levels of fat in their blood had ... Read more

Related support groups: Osteoporosis

Combo Drug Therapy May Work Best to Strengthen Bones: Study

Posted 14 May 2013 by Drugs.com

TUESDAY, May 14 – A new combination drug therapy for osteoporosis appears to increase bone density more effectively than any treatment now on the market, according to the results of a small clinical trial. Researchers found that postmenopausal women experienced significant amounts of bone growth by taking a bone-building drug called teriparatide with denosumab, a targeted therapy drug used to stop bone loss. "A combination of these two medications increased bone density more than either does on its own, and it is more effective than any currently approved therapy," said study author Dr. Benjamin Leder, who is with the endocrine unit at Massachusetts General Hospital in Boston. The 12-month study, published online May 15 in The Lancet, was funded in part by the drugs' makers, Eli Lilly and Amgen. It involved 94 postmenopausal women being treated for osteoporosis, a bone-thinning ... Read more

Related support groups: Osteoporosis, Forteo, Prolia, Xgeva, Denosumab, Teriparatide

Gene Discoveries Give Hope Against 'Brittle Bone' Disease

Posted 8 May 2013 by Drugs.com

WEDNESDAY, May 8 – Mutations in a gene involved in bone development appear to cause certain severe forms of bone loss, a finding that could lead to new therapies for the common bone-thinning disorder osteoporosis, researchers report. The mutations were found in a Swedish family with 10 members affected by a severe, early onset form of osteoporosis, as well as a Hmong family from Laos in which two sisters suffered from osteogenesis imperfecta. Osteogenesis imperfecta, which is also known as brittle bone disease, affects six to seven out of every 100,000 people worldwide. The disease causes the bones to break easily, often from little or no trauma. There are four main forms, the most severe of which is fatal before or soon after birth. The most common – and mildest – form is Type 1, in which most of a child's bone fractures happen before puberty. Some other problems, such as weak ... Read more

Related support groups: Osteoporosis

Healthy Older Women Advised Against Taking Calcium

Posted 25 Feb 2013 by Drugs.com

MONDAY, Feb. 25 – Healthy older women should not take calcium and vitamin D supplements to prevent fractures, according to a final recommendation issued Monday by the U.S. Preventive Services Task Force. In healthy adults, lower doses of calcium and vitamin D seem to be ineffective. As for higher doses, it's still up in the air, the government group said. The new recommendations do not apply to people who are known to be vitamin D-deficient or who already have osteoporosis, the U.S. Preventive Services Task Force (USPSTF) noted. Every year about 1.5 million fractures in the United States are attributed to osteoporosis, which is caused by a decrease in bone mass and density that makes bones fragile and more susceptible to a break. Almost half of all women older than 50 will have an osteoporosis-related fracture in their lifetime, according to the USPSTF. Calcium is one of the main ... Read more

Related support groups: Osteoporosis, Tums, Prevention of Osteoporosis, Caltrate, Calcium Citrate, Calcium Carbonate, Pepcid Complete, Citracal, Arthritis Pain Formula, Rolaids, Oyster, Oyster Shell, Calcium Chloride, Titralac, Calcium Gluconate, Os-Cal, Titralac Plus, Os-Cal 500, Slow-Mag, Ascriptin

Health Tip: You May Need a Bone Density Test

Posted 4 Jan 2013 by Drugs.com

-- A bone density test measures the amounts of calcium and other minerals in your bones, and how likely you are to develop thin and brittle bones – characteristics of a condition called osteoporosis. The womenshealth.gov website says your doctor should evaluate the following factors before recommending a bone density test: Your age, and whether you have become menopausal. How tall you are and how much you weigh. Whether you are a smoker and drink alcohol. Your family history of a broken hip, particularly among your parents. Medications you take. Whether you have a disorder that increases your risk of osteoporosis. Read more

Related support groups: Osteoporosis, Prevention of Osteoporosis, Osteopenia

Teen Girls Who Smoke May Up Risk for Future Bone Disease

Posted 4 Dec 2012 by Drugs.com

TUESDAY, Dec. 4 – Teen girls who smoke may be at greater risk for osteoporosis, according to a new study that found girls who smoke build up less bone during this critical growth period in their lives. In osteoporosis, bones lose mineral density and become brittle. People with the condition – which is much more common in women than men – are susceptible to fractures. "As much bone is accrued in the two years surrounding a girl's first menstrual cycle as is lost in the last four decades of life," said principal investigator, Lorah Dorn, director of research in the division of adolescent medicine at Cincinnati Children's Hospital Medical Center, in a center news release. The researchers examined how smoking, depression, anxiety and alcohol affected the buildup of bone among 262 girls ranging in age from 11 to 19 years old. Over the course of three years, the girls underwent clinical ... Read more

Related support groups: Smoking, Osteoporosis

Steroid Injections for Back Pain May Lower Bone Mass

Posted 2 Dec 2012 by Drugs.com

SATURDAY, Dec. 1 – Older women who get steroid injections in the spine to treat lower back pain may be at risk for bone loss in their hips, a small study suggests. It is well known that the anti-inflammatory steroid medications used to treat diseases such as asthma and rheumatoid arthritis may decrease a person's bone mass over time. But it hasn't been clear whether steroid shots – one treatment option for lower back pain – are connected to bone loss. "It's been thought that [the steroids] might stay in the epidural space of the spine," explained study author Dr. Shlomo Mandel, an orthopedic physician at Henry Ford West Bloomfield Hospital, in Michigan. Safety questions about steroid injections also have been raised in recent months, as U.S. health officials investigate a deadly outbreak of fungal meningitis linked to steroid shots produced by a Massachusetts compounding pharmacy ... Read more

Related support groups: Back Pain, Prednisone, Osteoporosis, Methylprednisolone, Prednisolone, Cortisone, Hydrocortisone, Medrol, Dexamethasone, Triamcinolone, Betamethasone, Decadron, Budesonide, Entocort, Solu-Medrol, Cortef, Celestone, Entocort EC, Orapred, Depo-Medrol

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