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Non-Small Cell Lung Cancer Blog

Related terms: Cancer, Lung, Non-Small Cell, Lung Cancer, Non-Small Cell, NSCLC

Cancer Patients' Secondary Symptoms Need Attention: Study

Posted 11 Oct 2010 by Drugs.com

MONDAY, Oct. 11 – Many cancer patients with pain or depression also experience physical symptoms, such as fatigue, dry mouth and nausea, that can cause disability, a new study shows. Doctors need to recognize and treat these symptoms in order to improve quality of life for cancer patients, said Dr. Kurt Kroenke, of the Richard Roudebush VA Medical Center, Indiana University, and Regenstrief Institute Inc. in Indianapolis, and colleagues. They analyzed data from 405 cancer patients who had either pain or depression and found that all the patients had at least one of 22 physical symptoms examined in the study. More than half of patients reported 15 of the 22 symptoms. The most common symptoms were fatigue (97.5 percent), difficulty sleeping (about 79 percent), pain in limbs or joints (78 percent), back pain (nearly 75 percent) and memory problems (72 percent). The patients also reported ... Read more

Related support groups: Cancer, Breast Cancer, Prostate Cancer, Lung Cancer, Renal Cell Carcinoma, Colorectal Cancer, Breast Cancer, Metastatic, Basal Cell Carcinoma, Non-Small Cell Lung Cancer, Brain Tumor, Pancreatic Cancer, Ovarian Cancer, Skin Cancer, Melanoma, Osteosarcoma, Breast Cancer - Adjuvant, Bladder Cancer, Endometrial Cancer, Cervical Cancer, Melanoma - Metastatic

Blacks Likely to Benefit From Targeted Lung Cancer Therapy

Posted 28 Sep 2010 by Drugs.com

TUESDAY, Sept. 28 – Despite previous findings to the contrary, new research indicates that black patients with non-small cell lung are as likely to harbor a specific mutation in tumors as white patients. This means that black patients should be at least as likely as white patients to benefit from highly effective therapies that target the mutation, such as the drug known as erlotinib, the researchers said. "This study has immediate implications for patient management," Ramsi Haddad, director of the Laboratory of Translational Oncogenomics at the Barbara Ann Karmanos Cancer Institute in Detroit, said in a news release from the American Association for Cancer Research. The mutation involves the epidermal growth factor receptor (EGFR) protein, which is seen in abnormally high numbers on the surface of cancer cells and associated with cancer spread. EGFR mutations increase the tumor's ... Read more

Related support groups: Non-Small Cell Lung Cancer

Can Fruits, Veggies Help Ward Off Lung Cancer?

Posted 1 Sep 2010 by Drugs.com

TUESDAY, Aug. 31 – Eating a wide variety of fruits and vegetables may help protect some smokers from lung cancer, a new European study suggests. But, the researchers stressed that quitting smoking will do far more to reduce risk than "an apple a day" or having a salad for lunch. In the study, participants who ate a diet that contained a diverse mix of fruits and vegetables appeared to have a 27 percent lowered risk of a common type of lung cancer, the researchers reported. "First and foremost, the best way to reduce one's risk of lung cancer is to quit smoking. That is of paramount importance," said principal investigator Dr. H. Bas Bueno-de-Mesquita, project director of cancer epidemiology at the National Institute for Public Health and the Environment in the Netherlands. "However, we realize that there are still millions worldwide who cannot and don't want to quit smoking. To just ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer

Many Docs Deliver Cancer Diagnosis Badly: Study

Posted 7 Jul 2010 by Drugs.com

WEDNESDAY, July 7 – One patient found out he had cancer by reading his radiology report. Another got the news when her neurologist called to say he had arranged for her to see a neurosurgeon. When she asked why, the doctor told her she had a brain tumor and hung up. A third learned she had breast cancer listening to her answering machine with her grandson sitting on her lap. A new study about how people learn of cancer diagnoses finds that many doctors have poor communication skills and often leave patients stranded with devastating information about a deadly illness, sometimes in a public setting. One-third of the cancer patients in the U.S. National Cancer Institute study recalled being told on the phone, in an emergency room, radiology department or other public hospital setting that they had cancer, most often leukemia, lymphoma or brain tumors. "It's really dismaying to think that ... Read more

Related support groups: Cancer, Breast Cancer, Prostate Cancer, Lung Cancer, Renal Cell Carcinoma, Colorectal Cancer, Breast Cancer, Metastatic, Basal Cell Carcinoma, Non-Small Cell Lung Cancer, Brain Tumor, Pancreatic Cancer, Ovarian Cancer, Skin Cancer, Melanoma, Osteosarcoma, Breast Cancer - Adjuvant, Bladder Cancer, Endometrial Cancer, Melanoma - Metastatic, Cervical Cancer

Tailored Treatment for Advanced Lung Cancer?

Posted 23 Jun 2010 by Drugs.com

WEDNESDAY, June 23 – Advanced lung cancer is notoriously hard to treat, but a team of Japanese scientists reports that a cancer drug known as Iressa was significantly more effective than standard chemotherapy for patients with a certain genetic profile. These patients have an advanced form of the most common type of lung cancer – non-small cell lung cancer – and a mutation of a protein found on the surface of certain cells that causes them to divide. This protein – known as epidermal growth factor receptor (EGFR) – is found in unusually high numbers on the surface of some cancer cells. The researchers focused on gefitinib (Iressa), which stops the protein receptor from sending a message to the cancer cells to divide and grow. In their study, reported in the June 24 issue of the New England Journal of Medicine, the drug had a better safety profile and improved survival time with no ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Iressa

Cost-Conscious Cancer Survivors Skip Care

Posted 14 Jun 2010 by Drugs.com

MONDAY, June 14 – Millions of Americans with a history of cancer, particularly people under age 65, are delaying or skimping on medical care because of worries about the cost of treatment, a new study suggests. The finding raises troubling questions about the long-term survival and quality of life of the 12 million adults in the United States whose lives have been forever changed by a diagnosis of cancer. "I think it's concerning because we recognize that cancer survivors have many medical needs that persist for years after their diagnosis and treatment," said study lead author Kathryn E. Weaver, an assistant professor in the Department of Social Sciences & Health Policy at Wake Forest University Baptist Medical Center in Winston-Salem, N.C. The report was published online June 14 in Cancer, a journal of the American Cancer Society. Cost concerns have posed a threat to cancer ... Read more

Related support groups: Cancer, Breast Cancer, Prostate Cancer, Lung Cancer, Renal Cell Carcinoma, Colorectal Cancer, Breast Cancer, Metastatic, Basal Cell Carcinoma, Non-Small Cell Lung Cancer, Brain Tumor, Pancreatic Cancer, Ovarian Cancer, Skin Cancer, Melanoma, Osteosarcoma, Breast Cancer - Adjuvant, Bladder Cancer, Endometrial Cancer, Cervical Cancer, Melanoma - Metastatic

Researchers Report Treatment Headway Against Lung Cancer

Posted 7 Jun 2010 by Drugs.com

SATURDAY, June 5 – Researchers report they prolonged survival for some patients with advanced non-small cell lung cancer, for whom the median survival is currently only about six months. One study discovered that an experimental drug called crizotinib shrank tumors in the majority of lung cancer patients with a specific gene variant. An estimated 5 percent of lung cancer patients, or roughly 40,000 people worldwide, have this gene variant. A second study found that a double-chemotherapy regimen benefited elderly patients, who represent the majority of those with lung cancer worldwide. Roughly 100,000 patients with lung cancer in the United States are over the age of 70. "This is our toughest cancer in many ways," said Dr. Mark Kris, moderator of a Saturday press conference at the annual meeting of the American Society of Clinical Oncology (ASCO), in Chicago. "It affects 220,000 ... Read more

Related support groups: Non-Small Cell Lung Cancer

Don't Count on Selenium to Prevent Lung Cancer Recurrence

Posted 7 Jun 2010 by Drugs.com

SATURDAY, June 5 – Taking the popular mineral supplement selenium doesn't reduce the likelihood of lung cancer recurrence, a new study reveals. Lead author Dr. Daniel D. Karp, a professor in the department of thoracic/head and neck medical oncology at the University of Texas M.D. Anderson Cancer Center, is scheduled to present the finding Saturday at the American Society of Clinical Oncology annual meeting, in Chicago. "Several epidemiological and animal studies have long-suggested a link between deficiency of selenium and cancer development," said Karp in a news release. "Interest and research escalated in the late 1990s after a skin cancer and selenium study, published in 1996, found no benefit against the skin cancer, but did suggest an approximate 30 percent reduction of prostate and lung cancers. Our lung cancer research and another major study for the prevention of prostate ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Selenium, Selepen, Selenium TR, Sele-Pak

IV Treatment May Thwart Advanced Cancers

Posted 22 May 2010 by Drugs.com

FRIDAY, May 21 – New preliminary research suggests that intravenous delivery of a cancer-destroying virus – a form of gene therapy – can destroy tumor cells throughout the body. Twenty-three patients whose colorectal, skin, ovarian and lung cancers had spread through their bodies received one of five dose levels of IV treatment. In 75 percent of those who received the highest doses, the treatment reached tumors and stopped cancer growth, the researchers said in a news release. Cancer was also suppressed in some who got lower doses. The patients reported mild side effects, such as symptoms similar to that of flu. "This is the first time that we've been able to treat patients intravenously and had proven success in targeting and destroying metastatic cancers in the body with an armed oncolytic virus product," said Dr. David H. Kirn, president and chief executive officer of Jennerex ... Read more

Related support groups: Cancer, Lung Cancer, Colorectal Cancer, Basal Cell Carcinoma, Non-Small Cell Lung Cancer, Ovarian Cancer, Skin Cancer, Melanoma, Melanoma - Metastatic, Small Cell Lung Cancer, Squamous Cell Carcinoma

Post-Chemo Treatment May Boost Lung Cancer Survival

Posted 20 May 2010 by Drugs.com

THURSDAY, May 20 – Among people with non-small-cell lung cancer, treatment with the drug erlotinib (Tarceva) after chemotherapy appears to slightly boost survival rates, a new study suggests. Non-small-cell lung cancer makes up about 85 percent of lung cancer cases. About half the time, people have advanced disease when diagnosed and are treated solely with chemotherapy, usually platinum-based chemo. But chemotherapy only boosts survival by eight to 10 months, the study authors noted. The study findings, which support the use of erlotinib as a "maintenance" treatment, are based on research by Dr. Federico Cappuzzo of the Civil Hospital of Livorno in Italy and his colleagues. The researchers tested the drug in 889 people who'd had chemotherapy and whose disease had not gotten worse. They were randomly assigned to take erlotinib an inactive placebo. According to the study, published ... Read more

Related support groups: Tarceva, Non-Small Cell Lung Cancer, Erlotinib

Lung Cancer Increase in Women Tied to Genes, Estrogen

Posted 19 Apr 2010 by Drugs.com

MONDAY, April 19 – Researchers working with mice report they've gained insight into why lung cancer rates are going up in women, including those who don't smoke. In a new study, they say they've found that smoke exposure leads to changes in how genes operate in female mice. This, in turn, appears to affect the body's processing of estrogen, which could contribute to lung cancer in non-smoking women as well as smokers. "Previous work has suggested that estrogen may play a role in lung cancer, but no one has shown that smoke can actually accelerate the metabolism of estrogen within the lungs," said Margie Clapper, co-leader of the Cancer Prevention and Control Program at Fox Chase Cancer Center in Philadelphia, in a statement. The research jibes with other findings that suggest women with lung cancer who are on hormone replacement therapy do worse than women who aren't, regardless of ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer

FDA Approves Tarceva as a Maintenance Therapy for Advanced Non-Small Cell Lung Cancer

Posted 18 Apr 2010 by Drugs.com

MELVILLE, N.Y., Apr 16, 2010 (BUSINESS WIRE) – OSI Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved the daily pill Tarceva (erlotinib) as a maintenance treatment for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose disease has not progressed after four cycles of platinum-based first-line chemotherapy. "We are delighted that lung cancer patients and their physicians will have the option of beginning Tarceva therapy in the first-line maintenance setting. We believe that Tarceva, as the only medicine approved in the maintenance setting for the squamous and non-squamous forms of NSCLC, offers a valuable treatment option for these patients," said Colin Goddard, Ph.D., Chief Executive Officer of OSI Pharmaceuticals. "We remain committed to a strategy of maximizing the value of Tarceva as an important therapy ... Read more

Related support groups: Tarceva, Non-Small Cell Lung Cancer

Matching Tumor Types to Drugs Boosts Lung Cancer Outcomes

Posted 18 Apr 2010 by Drugs.com

SUNDAY, April 18 – The number one cancer killer, lung cancer, may be more susceptible to treatment when doctors match up targeted drugs to tumors with key genetic traits, a new study finds. The study – the first of its kind – found that, overall, 46 percent of patients with stage IV (advanced) non-small cell lung cancer gained control of their disease (a measure of overall survival) within two months of treatment when doctors matched chemotherapy to tumor biomarkers, compared to the 30 percent seen when patients were treated in the usual way. The finding "is an important step toward personalized medicine and marks a paradigm shift for clinical trials by demonstrating the feasibility of a biopsy-based, hypothesis-driven biomarker trial," study co-principal investigator Dr. Roy Herbst, professor of thoracic/head and neck medical oncology at the University of Texas M.D. Anderson Cancer ... Read more

Related support groups: Non-Small Cell Lung Cancer

Simple Test May Spot Early Lung Cancer

Posted 7 Apr 2010 by Drugs.com

WEDNESDAY, April 7 – Researchers may have found an easy way to detect lung cancer in its early or even pre-cancerous stages, as well as a way to reverse the start of the deadly disease with a readily available, over-the-counter drug. "It's incredibly, incredibly exciting," said Dr. Patrick Nana-Sinkam, a lung cancer expert with the Ohio State University Comprehensive Cancer Center, who was not involved with the new study. "This definitely has potential." The minimally invasive procedure involves using a small brush to collect a smattering of cells from the windpipe (a bronchoscopy), explained study co-author Andrea Bild, an assistant professor of pharmacology and toxicology at the University of Utah in Salt Lake City. Maybe one day, screening could be done using an even simpler nasal or sputum test, the researchers said. Currently, there is no good way to detect lung cancer – the ... Read more

Related support groups: Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer

Chemo May Boost Survival After Lung Cancer Surgery

Posted 24 Mar 2010 by Drugs.com

WEDNESDAY, March 24 – Chemotherapy improves survival for patients with operable non-small cell lung cancer, say researchers who reviewed nearly 50 studies. The first meta-analysis of 34 studies involving almost 8,500 patients (and more than 3,300 deaths) showed that survival at five years was 64 percent for patients who had chemotherapy and surgery, and 60 percent for patients who had surgery alone. The second meta-analysis of 13 studies with 2,660 patients (1,909 deaths) showed that survival at five years was 33 percent for patients who had surgery plus radiotherapy and chemotherapy, and 29 percent for patients who had surgery plus radiotherapy alone. The report was released online March 23 in advance of publication in an upcoming print issue of The Lancet. "In both meta-analyses we noted little variation in effect according to the type of chemotherapy, other trial characteristics, or ... Read more

Related support groups: Non-Small Cell Lung Cancer

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