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Is a Better Sleeping Pill on the Way?

Posted 3 Apr 2013 by Drugs.com

WEDNESDAY, April 3 – A new class of sleep medications appears to help people fall asleep without causing grogginess the next day, researchers say. These new medications – known as dual orexin receptor antagonists (DORA) – target a more specific region of the brain than popular sleep drugs such as Ambien and Lunesta, promoting sleep without affecting learning and memory (also called "cognition"), according to the new research. "We've shown that these compounds improve sleep at doses that don't impact cognition," said Jason Uslaner, lead author of a study published in the April 3 issue of Science Translational Medicine. Uslaner is director of In Vivo Pharmacology at Merck & Co., which funded the study. Merck already has one such drug, suvorexant, under review by the U.S. Food and Drug Administration (FDA). More than 30 million Americans struggle to get a good night's sleep, and about ... Read more

Sedatives May Raise Pneumonia Risk

Posted 5 Dec 2012 by Drugs.com

WEDNESDAY, Dec. 5 – People taking the widely prescribed sedatives known as benzodiazepines may be putting themselves at greater risk for developing pneumonia, British researchers report. Moreover, they may also face an increased risk of dying from the disease, the investigators added. Benzodiazepines such as Halcyon, Librium, Valium and Xanax are commonly prescribed for anxiety, epilepsy, muscle spasm and insomnia. "Our study calls into question the safety of benzodiazepine drugs in the context of infection," said study author Dr. Robert Sanders, a senior clinical research associate at the Wellcome Department of Imaging Neuroscience at the Institute of Cognitive Neuroscience at University College London. "While further study is required, this initial analysis suggests that benzodiazepine exposure may increase the risk of developing pneumonia or dying from pneumonia," he said. Sanders ... Read more

Psych, Sleep Meds May Affect Driving

Posted 13 Sep 2012 by Drugs.com

WEDNESDAY, Sept. 12 – People who take medication for anxiety, depression or insomnia may be at greater risk of having a car accident than drivers not taking psychotropic drugs, according to a new study. Noting that these drugs alter brain functioning and could impair driving ability, researchers from Taiwan said doctors should think about advising patients not to drive while taking these medications. "Our findings underscore that people taking these psychotropic drugs should pay increased attention to their driving performance in order to prevent motor vehicle accidents," said the study's lead researcher, Hui-Ju Tsai, who is based at the National Health Research Institutes in Zhunan. In conducting the study, the researchers compared drug use in nearly 5,200 people involved in major car accidents with that of more than 31,000 similar people with no record of serious accidents. The ... Read more

Another Drug 'Take-Back Day' Scheduled for Saturday

Posted 26 Apr 2012 by Drugs.com

THURSDAY, April 26 – The fourth National Prescription Drug Take-Back Day is scheduled for Saturday from 10 a.m. to 2 p.m., the U.S. Drug Enforcement Administration says. The event gives Americans an opportunity to safely dispose of unwanted and unused prescription drugs. At the third Take-Back Day last October, participants turned in more than 377,000 pounds (188.5 tons) of unwanted or expired medications at more than 5,300 sites located in all 50 states. In total, the three Take-Back Days have taken in nearly 1 million pounds of prescription drugs during the past 13 months. "The amount of prescription drugs turned in by the American public during the past three Take-Back Day events speaks volumes about the need to develop a convenient way to rid homes of unwanted or expired prescription drugs," DEA administrator Michele Leonhart said in an agency news release. "The DEA remains hard at ... Read more

Sleeping Pills Linked to Raised Risk of Death, Cancer: Study

Posted 27 Feb 2012 by Drugs.com

MONDAY, Feb. 27 – Prescription sleeping pills may help you get some much needed rest at night, but using them routinely might also make it more likely that you will die or develop certain types of cancer, research suggests. A new study suggests that those who take these medications are four times more likely to die than people who don't take them. What's more, the research shows that sleeping pills is also associated with a raised risk for certain cancers. The findings appear online Feb. 27 in the journal BMJ Open. Sleeping pills linked to these risks included benzodiazepines such as temazepam; non-benzodiazepines such as Ambien (zolpidem), Lunesta (eszopiclone) and Sonata (zaleplon); barbiturates; and sedative antihistamines. The new study only shows an association between the sleeping aids and death risk, not cause-and-effect, and many experts are urging caution in jumping to any ... Read more

Accidental Medication Poisonings in Kids on the Rise

Posted 16 Sep 2011 by Drugs.com

FRIDAY, Sept. 16 – Despite ongoing prevention efforts, a growing number of young children are being accidentally poisoned with medications, according to new research. The study, which was based on data reported to the American Association of Poison Control Centers between 2001 and 2008, found that medication poisoning among children aged 5 and under increased by 22 percent, although the number of children in the United States in this age group rose by only 8 percent during the study period. "The problem of pediatric poisoning in the U.S. is getting worse, not better," Dr. Randall Bond, of Cincinnati Children's Hospital Medical Center, said in a hospital news release. In conducting the study, which is scheduled for publication in the Journal of Pediatrics, the researchers reviewed information on over 544,000 children who landed in the emergency department due to medication poisoning ... Read more

Treatment for Abuse of Anti-Anxiety Drugs Tripled Over 10 Years

Posted 9 Jun 2011 by Drugs.com

THURSDAY, June 9 – Admissions for treatment of benzodiazepine abuse nearly tripled in the United States between 1998 and 2008, while overall admissions for substance abuse rose only 11 percent, according to a government study released Thursday. Benzodiazepines – a class of drugs prescribed to treat anxiety, insomnia and seizure disorders – include Valium, Halcion, Xanax, Ativan and Librium. Abuse of benzodiazepines, which were introduced in the 1950s to replace barbiturates, can lead to addiction, injury and death. The Substance Abuse and Mental Health Services Administration (SAMHSA) study found that admissions for treatment of benzodiazepine abuse among patients 12 and older rose from 22,400 in 1998 to 60,200 a decade later. Benzodiazepine-related admissions accounted for 3.2 percent of all substance abuse admissions in 2008, compared with 1.3 percent in 1998. Most admissions ... Read more

Epilepsy Drugs May Raise Fracture Risk in Older Adults

Posted 11 Jan 2011 by Drugs.com

TUESDAY, Jan. 11 – Epilepsy drugs increase older adults' risk for bone fractures, a new study shows. Canadian researchers analyzed the medical records of 15,792 people 50 and older who'd had non-traumatic fractures between April 1996 and March 2004. Each person was matched with up to three people who'd never had a fracture, for a total of 47,289 people to serve as controls. The researchers also looked at the participants' use of epilepsy drugs, including carbamazepine (Carbatrol, Epitol, Tegretol), clonazepam (Klonopin), ethosuximide (Zarontin), gabapentin (Gabarone, Neurontin), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek) and valproic acid (Depakene, Depakote). All but one of the drugs was associated with an increased risk for fractures. The greatest risk was among people taking phenytoin and carbamazepine. Valproic acid was the only drug not linked with an increased chance ... Read more

Psychotropic Medications Associated With Risk of Falls in Older Adults

Posted 1 Dec 2009 by Drugs.com

CHICAGO, Nov. 23, 2009 - Older adults who take several types of psychotropic medications—such as antidepressants or sedatives—appear more likely to experience falls, according to an analysis of previous studies reported in the November 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. More than 30 percent of individuals older than 65 will fall at least once a year, and falls and their complications are the fifth-leading cause of death in the developed world, according to background information in the article. Each year, 85 percent of all injury-related hospital admissions and more than 40 percent of nursing home admissions are related to falls, and the annual costs related to falls and their complications are estimated to be in the billions of dollars worldwide. Both internal and external risk factors contribute to falls, and medications have previously been i ... Read more

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