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Bipolar Disorder Drugs May 'Tweak' Genes Affecting Brain
Posted 25 Apr 2013 by Drugs.com
THURSDAY, April 25 – Medications taken by people with bipolar disorder may actually be nudging hundreds of genes that direct the brain to behave more normally, according to new research. The study suggests that antipsychotic drugs activate a wide range of genes, changing their function, said lead author Dr. Melvin McInnis. "A gene's activity in any given cell will vary depending on what it's exposed to," said McInnis, a professor of bipolar disorder and depression at the School of Medicine at the University of Michigan. It's not often that scientists stumble upon something in research that they totally weren't expecting to see. "It was a major surprise to us that people treated with an antipsychotic [medication] had changes in the gene expression pattern," McInnis said. The findings could help point the way to new gene-targeted and stem cell therapies, and provide valuable insight into ... Read more
Related support groups: Bipolar Disorder, Risperdal, Risperidone, Haldol, Haloperidol, Clozapine, Clozaril, Risperdal Consta, Haldol Decanoate, Clopine, Risperdal M-Tab, Versacloz, Clozapine Synthon, Zaponex, Denzapine
Psychiatric Drugs More Often Prescribed in the South
Posted 1 Feb 2013 by Drugs.com
FRIDAY, Feb. 1 – Use of psychiatric medications is most prevalent in the southern United States and least prevalent in the West, according to a new U.S. study. Although people living in the West are the least likely to use antipsychotics, antidepressants and stimulants, the Yale researchers found that the drugs' use is 40 percent higher in a large section of the South than in other parts of the country. The study authors attributed this discrepancy to variations in local access to health care and marketing efforts within the pharmaceutical industry. "The geographic patterns we identify are striking and map onto the patterns found for a host of other medical conditions and treatments, from cognitive decline to bypass surgery," Marissa King, assistant professor of organizational behavior at the Yale School of Management, said in a school news release. "Our work suggests that access to ... Read more
Related support groups: Depression, Bipolar Disorder, Adderall, Lexapro, Zoloft, Cymbalta, Wellbutrin, Effexor, Prozac, Seroquel, Celexa, Phentermine, Paxil, Vyvanse, Trazodone
Older Antipsychotics May Work as Well as Newer Ones: Review
Posted 14 Aug 2012 by Drugs.com
TUESDAY, Aug. 14 – Newer, more expensive schizophrenia medications are not noticeably better than their older, cheaper counterparts, a new review suggests. Currently, 75 percent of U.S. adults who are prescribed antipsychotic medications take these second-generation drugs, which were developed largely due to concerns about side effects with their predecessors, experts noted. First-generation antipsychotics are also called typical antipsychotics. This class of drugs includes chlorpromazine (Thorazine), haloperidol (Haldol), perphenazine (Etrafon, Trilafon) and fluphenazine (Prolixin). Second-generation drugs, known as atypical, antipsychotics include risperidone (Risperdal), aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine Fumarate (Seroquel) and ziprasidone (Geodon). There is a major cost difference between the two classes of drugs: For example, a month's supply of olanzapine ... Read more
Related support groups: Seroquel, Abilify, Zyprexa, Geodon, Risperdal, Seroquel XR, Saphris, Risperidone, Latuda, Quetiapine, Haldol, Olanzapine, Invega, Haloperidol, Clozapine
Certain Antipsychotics Up Risk of Death for Patients With Dementia: Study
Posted 23 Feb 2012 by Drugs.com
THURSDAY, Feb. 23 Compared to other antipsychotic drugs, haloperidol (Haldol) raises the risk of death in elderly patients with dementia, a new study finds. One outside expert believes the finding should aid in dementia care. "This data provides much-needed guidance and reassurance for the ever-increasing number of health care practitioners treating older demented patients," said Dr. Gisele Wolf-Klein, director of geriatric education at the North Shore-LIJ Health System in New Hyde Park, N.Y. The study was published online Feb. 23 in the British Medical Journal. In 2005, the U.S. Food and Drug Administration warned that certain antipsychotic drugs are associated with an increased risk of death in elderly patients with dementia. This warning was expanded to include conventional antipsychotics in 2008, according to a journal news release. The authors of the new study said that, despite ... Read more
Related support groups: Seroquel, Abilify, Zyprexa, Geodon, Risperdal, Seroquel XR, Risperidone, Dementia, Quetiapine, Haldol, Olanzapine, Haloperidol, Zyprexa Zydis, Aripiprazole, Ziprasidone
Antipsychotics Best for Controlling Mania: Study
Posted 16 Aug 2011 by Drugs.com
TUESDAY, Aug. 16 – The manic episodes experienced by those with bipolar disorder are better controlled by antipsychotic drugs than mood stabilizers, a new, large study suggests. Researchers from Italy and the United Kingdom also found that three antipsychotics – first-generation haloperidol (Haldol) along with later formulations of risperidone (Risperdal) and olanzapine (Zyprexa) – outperformed 11 other drugs. The scientists analyzed results from 68 randomized, controlled trials with more than 16,000 participants over a 30-year period. Mania typically alternates with depression in those with bipolar disorder, which tends to run in families and begin between the ages of 15 and 25, according to the U.S. National Institutes of Health. Acute manic episodes – characterized by hyperactivity, racing thoughts and reckless behavior – are not experienced by all bipolar patients, but severe ... Read more
Related support groups: Bipolar Disorder, Seroquel, Abilify, Mania, Zyprexa, Geodon, Risperdal, Seroquel XR, Saphris, Risperidone, Latuda, Quetiapine, Haldol, Olanzapine, Haloperidol
Schizophrenia Drugs May Spur Subtle Brain Tissue Loss
Posted 10 Feb 2011 by Drugs.com
MONDAY, Feb. 7 – The use of antipsychotic drugs to treat schizophrenia is associated with the loss of a small but measurable amount of brain tissue, a new study finds. It included 211 schizophrenia patients who each underwent an average of three MRI brain scans over 7.2 years, for a total of 674 scans in the study group. The researchers then examined how four factors affected changes in brain volume over time: illness duration, illness severity, substance abuse and treatment with antipsychotic drugs. Longer duration of illness and antipsychotic treatment were both associated with loss of brain tissue. Higher doses of antipsychotics were associated with overall brain tissue loss, reduced gray matter and progressive declines in white matter. Illness severity and substance abuse had little or no association with brain tissue changes, according to the study, published in the February issue ... Read more
Related support groups: Seroquel, Abilify, Lithium, Schizophrenia, Zyprexa, Geodon, Risperdal, Seroquel XR, Saphris, Risperidone, Quetiapine, Haldol, Olanzapine, Invega, Haloperidol
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