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Ultrasound Might Speed Up Digestive Drug Delivery: Animal Study

Posted 21 Oct 2015 by

WEDNESDAY, Oct. 21, 2015 – Ultrasound waves could be used to rapidly deliver drugs to the digestive system, new animal research suggests. This new approach to drug delivery might potentially benefit people with inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. However, this new method of drug delivery hasn't yet been tested in humans. "With additional research, our technology could prove invaluable in both clinical and research settings, enabling improved therapies and expansion of research techniques applied to the [gastrointestinal] tract," said co-senior study author Daniel Blankschtein, a professor of chemical engineering at Massachusetts Institute of Technology (MIT) in Cambridge. "[Our study] demonstrates for the first time the active administration of drugs, including biologics, through the GI tract," he said in an MIT news release. The ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance, Diagnosis and Investigation

Crohn's Disease Treatments for Kids May Not Get Gut Back to Normal

Posted 14 Oct 2015 by

WEDNESDAY, Oct. 14, 2015 – Current therapies for children with Crohn's disease don't fully restore healthy bacteria and fungi populations in their digestive systems, a new study shows. These findings suggest that treatments don't have to bring bacteria and other microbe levels back to normal levels in the gut to be useful. This knowledge could lead to new approaches for diagnosing and treating inflammatory bowel disease, according to the Oct. 14 study in the journal Cell Host & Microbe. "We show that microbes in the gut respond to treatment of inflammatory bowel disease in a much more complex way than has been previously appreciated," co-principal investigator Gary Wu, from the University of Pennsylvania in Philadelphia, said in a journal news release. "The results of our study provide information that could be used to track or predict disease, as well as new diet-based therapeutic ... Read more

Related support groups: Prednisone, Methylprednisolone, Crohn's Disease, Prednisolone, Medrol, Dexamethasone, Hydrocortisone, Cortisone, Triamcinolone, Asacol, Crohn's Disease - Maintenance, Betamethasone, Sulfasalazine, Pentasa, Budesonide, Lialda, Crohn's Disease - Acute, Decadron, Entocort, Solu-Medrol

More Evidence High-Fiber, Mediterranean Diet Is Good for You

Posted 29 Sep 2015 by

TUESDAY, Sept. 29, 2015 – Numerous studies have extolled the health benefits of the Mediterranean diet. Now, research suggests the regimen may also boost levels of beneficial fatty acids. These so-called "short chain fatty acids" are produced by bacteria in the intestine during fermentation of insoluble fiber from fruits, vegetables and legumes. The fatty acids are believed to provide a number of health benefits, including a lower risk of diabetes, heart disease and inflammatory diseases, an Italian team reports in the Sept. 29 issue of the journal Gut. "We provide here tangible evidence of the impact of a healthy diet and a Mediterranean dietary pattern," wrote the team led by Danilo Ercolini, a professor of microbiology at the University of Naples in Italy. The study of 153 Italian adults found higher levels of short chain fatty acids in vegans, vegetarians and those who closely ... Read more

Related support groups: Diabetes, Type 2, Heart Disease, Crohn's Disease, Ulcerative Colitis, Fish Oil, Lovaza, Inflammatory Bowel Disease, Omega-3, Dietary Fiber Supplementation, Omacor, MaxEPA, Omega-3 Polyunsaturated Fatty Acids, Animi-3, Marine Lipid Concentrate, Lactobacillus Casei/omega-3 Polyunsaturated Fatty Acids, Omega-500, Omega Essentials, EPA Fish Oil, Restora, Sea-Omega

Crohn's Disease, Colitis Tied to Anxiety in Study

Posted 4 Aug 2015 by

TUESDAY, Aug. 4, 2015 – People with inflammatory bowel disease, such as Crohn's disease or ulcerative colitis, have an increased risk for an anxiety disorder, especially women, a new study suggests. Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation of the digestive tract. "Patients with IBD face substantial chronic physical problems associated with the disease," lead author Esme Fuller-Thomson, a professor from the University of Toronto, said in a university news release. "The additional burden of anxiety disorders makes life much more challenging so this 'double jeopardy' must be addressed." The study authors looked at 269 Canadian adults who had been diagnosed with an inflammatory bowel disease. The researchers found that these patients were two times more likely to have had generalized anxiety disorder at some point in their lives than adults ... Read more

Related support groups: Anxiety, Generalized Anxiety Disorder, Panic Disorder, Anxiety and Stress, Post Traumatic Stress Disorder, Social Anxiety Disorder, Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Performance Anxiety, Lymphocytic Colitis, Allergic Colitis

Stem Cells, Fecal Transplants Show Promise for Crohn's Disease

Posted 10 Apr 2015 by

FRIDAY, April 10, 2015 – Two experimental therapies might help manage the inflammatory bowel disorder Crohn's disease, if this early research pans out. In one study, researchers found that a fecal transplant – stool samples taken from a healthy donor – seemed to send Crohn's symptoms into remission in seven of nine children treated. In another, a separate research team showed that stem cells can have lasting benefits for a serious Crohn's complication called fistula. According to the Crohn's & Colitis Foundation, up to 700,000 Americans have Crohn's – a chronic inflammatory disease that causes abdominal cramps, diarrhea, constipation and rectal bleeding. It arises when the immune system mistakenly attacks the lining of the digestive tract. A number of drugs are available to treat Crohn's, including drugs called biologics, which block certain immune-system proteins. But fecal ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

New Drug for Crohn's Disease Shows Early Promise

Posted 18 Mar 2015 by

WEDNESDAY, March 18, 2015 – An experimental drug may quickly quash symptoms of the digestive disorder Crohn's disease – at least for the short term, an early clinical trial finds. The study, of more than 150 adults with Crohn's, found that just two weeks of treatment sent many into remission – meaning they had few to no symptoms of the inflammatory bowel disease 28 days after the study began. Experts said the findings are encouraging. For one, the drug is a pill, whereas the current "biologic" drugs for Crohn's – such as Remicade and Humira – are given by injection or IV. And the drug worked quickly. "There was a pretty high remission rate in a short period of time. That's impressive," said Dr. Raymond Cross, a gastroenterologist at the University of Maryland Medical Center, who was not involved in the study. In theory, the new drug – dubbed mongersen – could be safer than ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Acute

Slowed Growth Could Signal Crohn's Disease in Kids

Posted 18 Mar 2015 by

WEDNESDAY, March 18, 2015 – A lag in growth could be a sign that a child might suffer from undiagnosed inflammatory bowel disease (IBD), especially Crohn's disease, one pediatric doctor says. "Growth charts are one of the most important things we look at with children because sometimes a slower growth rate is the only sign of IBD, especially with Crohn's disease," Dr. Marc Schaefer, a pediatric gastroenterologist, said in a Penn State University news release. Other symptoms of inflammatory bowel disease in children include not wanting to eat, persistent stomach pains, and diarrhea or bloody stools, said Schaefer, who works at Penn State Hershey Children's Hospital in Hershey, Pa. Children with these symptoms should be evaluated, he suggested. Blood tests and endoscopy are also used to diagnose and to distinguish Crohn's from ulcerative colitis, another type of inflammatory bowel ... Read more

Related support groups: Crohn's Disease, Inflammatory Bowel Disease, Growth Retardation

Black Children May Fare Worse With Crohn's Disease

Posted 10 Mar 2015 by

TUESDAY, March 10, 2015 – Race may play a role in outcomes for children and teens with Crohn's disease, with black patients faring worse than whites, a new study suggests. "We found racial inequalities exist among children and adolescents with Crohn's disease, likely due to a combination of genetic and environmental differences," Dr. Jennifer Dotson, a gastroenterologist at Nationwide Children's Hospital and principal investigator in the Center for Innovation and Pediatric Practice, said in a hospital news release. Researchers analyzed data from more than 4,000 white and black patients with moderate to severe Crohn's disease. They were all aged 21 or younger. All had been hospitalized due to the digestive system disease between 2004 and 2012. Black patients were 1.5 times more likely to be readmitted to the hospital and required readmission sooner than white patients, according to the ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Viruses May Play Role in Crohn's Disease, Colitis: Study

Posted 23 Jan 2015 by

FRIDAY, Jan. 23, 2015 – Viruses may play a role in inflammatory bowel diseases, including the two most common types, Crohn's disease and ulcerative colitis, a new study reveals. Previous research has linked these bowel diseases with a lower variety of bacteria in the gut, according to the researchers. In this new study, people with inflammatory bowel disease had a greater variety of viruses in their digestive systems compared to healthy people, the investigators found. The findings suggest that viruses, as well as bacteria, are a factor in inflammatory bowel disease, according to the study published online Jan. 22 in the journal Cell. The findings are the "tip of the iceberg," said study senior author Dr. Herbert Virgin IV, a professor of pathology and head of the department of pathology and immunology at Washington University School of Medicine in St. Louis. Much more research is ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis

Crohn's, Colitis May Have Genetic Underpinnings, Study Finds

Posted 19 Dec 2014 by

FRIDAY, Dec. 19, 2014 – The intestinal bacteria that cause inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, may be inherited, researchers report. The findings, published recently in the journal Genome Medicine, could help in efforts to prevent the disease and treat the 1.6 million Americans with Crohn's or colitis, the study authors added. "The intestinal bacteria, or 'gut microbiome,' you develop at a very young age can have a big impact on your health for the rest of your life," lead author Dan Knights, an assistant professor in the department of computer science and engineering and the Biotechnology Institute at the University of Minnesota, said in a journal news release. "We have found groups of genes that may play a role in shaping the development of imbalanced gut microbes," he explained. The study of 474 adults with inflammatory bowel disease ... Read more

Related support groups: Crohn's Disease, Inflammatory Bowel Disease, Pseudomembranous Colitis

Scientists Grow, Implant Human Intestinal Tissue in Mice

Posted 20 Oct 2014 by

SUNDAY, Oct. 19, 2014 – New stem cell-based research could improve understanding of intestinal diseases and eventually lead to new treatments, a new study suggests. Scientists used stem cells to grow "organoids" of functioning human intestinal tissue in a lab dish. They then transplanted the organoids into mice, creating a new model for studying intestinal disorders, according to the researchers. "This provides a new way to study the many diseases and conditions that can cause intestinal failure, from genetic disorders appearing at birth to conditions that strike later in life, such as cancer and Crohn's disease," lead investigator Dr. Michael Helmrath, surgical director of the Intestinal Rehabilitation Program at the Cincinnati Children's Hospital Medical Center, said in a center news release. "These studies also advance the longer-term goal of growing tissues that can replace damaged ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Certain Autoimmune Drugs in Pregnancy May Up Newborn Infection Risk: Study

Posted 3 Oct 2014 by

FRIDAY, Oct. 3, 2014 – When given to pregnant women, a common treatment for ulcerative colitis may inadvertently lower their baby's ability to fight off infections at birth, new French research suggests. The treatment, called anti-TNF therapy, is an injected, artificial antibody. This type of medication is widely seen as a safe and effective way to tackle a wide range of autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel conditions that include ulcerative colitis and Crohn's disease. It's not unusual for pregnant women to receive the treatment, given that inflammatory bowel diseases often strike women of childbearing age. However, this type of drug can cross the placenta and reach the fetus, the study authors said. And four French cases – all involving babies born to women exposed to Remicade (infliximab) during pregnancy – suggest the therapy may cause newborn ... Read more

Related support groups: Rheumatoid Arthritis, Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Cimzia, Inflammatory Bowel Disease, Simponi, Infliximab, Adalimumab, Etanercept, Golimumab, Certolizumab

FDA Approves Humira (adalimumab) for the Treatment of Pediatric Patients with Crohn's Disease

Posted 26 Sep 2014 by

NORTH CHICAGO, Ill., Sept. 25, 2014 /PRNewswire/ – AbbVie announced today that the U.S. Food and Drug Administration (FDA) has approved Humira (adalimumab) for reducing signs and symptoms, and achieving and maintaining clinical remission, in pediatric Crohn's disease patients 6 years of age and older when certain other treatments have not worked well enough. This FDA approval represents the eighth indication for Humira in the United States and makes it the first and only biologic treatment approved for use in this patient population that can be administered at home. "Moderate to severe Crohn's disease is a serious chronic disorder that can impact children and adolescents in significant ways during this important stage of their lives," said Jeffrey S. Hyams, M.D., head, Division of Digestive Diseases, Hepatology and Nutrition, Connecticut Children's Medical Center. "The approval of ... Read more

Related support groups: Humira, Crohn's Disease, Adalimumab

Scientists Spot Genetic Clues to Crohn's Disease

Posted 27 Aug 2014 by

WEDNESDAY, Aug. 27, 2014 – A new genetic discovery about Crohn's disease could lead to different ways to fight the bowel disorder, researchers report. The scientists pinpointed chemical changes in Crohn's patients' DNA that affect how their genes work, and said these changes can be detected in blood samples. Along with raising the possibility of a simple diagnostic test for Crohn's, the findings provide new insight into how the disease develops and suggest possible gene targets for new treatments, said the authors of the study. It was published Aug. 26 in the journal Inflammatory Bowel Diseases. Previous research has found several genes linked to Crohn's, but not everyone who has the genes develops the condition. The findings of this new study involving children with Crohn's disease in Scotland suggest that differences in environmental factors among people – such as diet and gut ... Read more

Related support groups: Crohn's Disease

Popular Crohn's, Colitis Drugs Not Linked to Short-Term Cancer Risk: Study

Posted 18 Jun 2014 by

WEDNESDAY, June 18, 2014 – A popular class of drugs used to treat inflammatory bowel disease isn't linked to an increase in the short-term risk of cancer, Danish researchers report. Researchers found that people with Crohn's disease or colitis who received the drugs – tumor necrosis factor alpha (TNF-a) antagonists – had about the same risk of cancer as other people with these inflammatory bowel diseases who were not treated with the medication. The drugs work by interrupting the function of TNF-a, a substance used by the immune system to increase inflammation. "Treatment with these drugs inhibits the inflammatory response in the gastrointestinal tract thereby leading to reduced symptoms," said lead author Dr. Nynne Nyboe Andersen of the Statens Serum Institute in Copenhagen. The problem is that TNF-a also serves a key role in protecting the body against cancer, raising concerns that ... Read more

Related support groups: Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Colorectal Cancer, Inflammatory Bowel Disease, Cimzia, Simponi, Infliximab, Adalimumab, Etanercept, Golimumab, Certolizumab

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