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Crohn's Disease, Colitis Tied to Anxiety in Study

Posted 4 Aug 2015 by Drugs.com

TUESDAY, Aug. 4, 2015 – People with inflammatory bowel disease, such as Crohn's disease or ulcerative colitis, have an increased risk for an anxiety disorder, especially women, a new study suggests. Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation of the digestive tract. "Patients with IBD face substantial chronic physical problems associated with the disease," lead author Esme Fuller-Thomson, a professor from the University of Toronto, said in a university news release. "The additional burden of anxiety disorders makes life much more challenging so this 'double jeopardy' must be addressed." The study authors looked at 269 Canadian adults who had been diagnosed with an inflammatory bowel disease. The researchers found that these patients were two times more likely to have had generalized anxiety disorder at some point in their lives than adults ... Read more

Related support groups: Anxiety, Generalized Anxiety Disorder, Panic Disorder, Anxiety and Stress, Post Traumatic Stress Disorder, Social Anxiety Disorder, Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance, Performance Anxiety, Lymphocytic Colitis, Allergic Colitis

Stem Cells, Fecal Transplants Show Promise for Crohn's Disease

Posted 10 Apr 2015 by Drugs.com

FRIDAY, April 10, 2015 – Two experimental therapies might help manage the inflammatory bowel disorder Crohn's disease, if this early research pans out. In one study, researchers found that a fecal transplant – stool samples taken from a healthy donor – seemed to send Crohn's symptoms into remission in seven of nine children treated. In another, a separate research team showed that stem cells can have lasting benefits for a serious Crohn's complication called fistula. According to the Crohn's & Colitis Foundation, up to 700,000 Americans have Crohn's – a chronic inflammatory disease that causes abdominal cramps, diarrhea, constipation and rectal bleeding. It arises when the immune system mistakenly attacks the lining of the digestive tract. A number of drugs are available to treat Crohn's, including drugs called biologics, which block certain immune-system proteins. But fecal ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

New Drug for Crohn's Disease Shows Early Promise

Posted 18 Mar 2015 by Drugs.com

WEDNESDAY, March 18, 2015 – An experimental drug may quickly quash symptoms of the digestive disorder Crohn's disease – at least for the short term, an early clinical trial finds. The study, of more than 150 adults with Crohn's, found that just two weeks of treatment sent many into remission – meaning they had few to no symptoms of the inflammatory bowel disease 28 days after the study began. Experts said the findings are encouraging. For one, the drug is a pill, whereas the current "biologic" drugs for Crohn's – such as Remicade and Humira – are given by injection or IV. And the drug worked quickly. "There was a pretty high remission rate in a short period of time. That's impressive," said Dr. Raymond Cross, a gastroenterologist at the University of Maryland Medical Center, who was not involved in the study. In theory, the new drug – dubbed mongersen – could be safer than ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Acute

Slowed Growth Could Signal Crohn's Disease in Kids

Posted 18 Mar 2015 by Drugs.com

WEDNESDAY, March 18, 2015 – A lag in growth could be a sign that a child might suffer from undiagnosed inflammatory bowel disease (IBD), especially Crohn's disease, one pediatric doctor says. "Growth charts are one of the most important things we look at with children because sometimes a slower growth rate is the only sign of IBD, especially with Crohn's disease," Dr. Marc Schaefer, a pediatric gastroenterologist, said in a Penn State University news release. Other symptoms of inflammatory bowel disease in children include not wanting to eat, persistent stomach pains, and diarrhea or bloody stools, said Schaefer, who works at Penn State Hershey Children's Hospital in Hershey, Pa. Children with these symptoms should be evaluated, he suggested. Blood tests and endoscopy are also used to diagnose and to distinguish Crohn's from ulcerative colitis, another type of inflammatory bowel ... Read more

Related support groups: Crohn's Disease, Inflammatory Bowel Disease, Growth Retardation

Black Children May Fare Worse With Crohn's Disease

Posted 10 Mar 2015 by Drugs.com

TUESDAY, March 10, 2015 – Race may play a role in outcomes for children and teens with Crohn's disease, with black patients faring worse than whites, a new study suggests. "We found racial inequalities exist among children and adolescents with Crohn's disease, likely due to a combination of genetic and environmental differences," Dr. Jennifer Dotson, a gastroenterologist at Nationwide Children's Hospital and principal investigator in the Center for Innovation and Pediatric Practice, said in a hospital news release. Researchers analyzed data from more than 4,000 white and black patients with moderate to severe Crohn's disease. They were all aged 21 or younger. All had been hospitalized due to the digestive system disease between 2004 and 2012. Black patients were 1.5 times more likely to be readmitted to the hospital and required readmission sooner than white patients, according to the ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Viruses May Play Role in Crohn's Disease, Colitis: Study

Posted 23 Jan 2015 by Drugs.com

FRIDAY, Jan. 23, 2015 – Viruses may play a role in inflammatory bowel diseases, including the two most common types, Crohn's disease and ulcerative colitis, a new study reveals. Previous research has linked these bowel diseases with a lower variety of bacteria in the gut, according to the researchers. In this new study, people with inflammatory bowel disease had a greater variety of viruses in their digestive systems compared to healthy people, the investigators found. The findings suggest that viruses, as well as bacteria, are a factor in inflammatory bowel disease, according to the study published online Jan. 22 in the journal Cell. The findings are the "tip of the iceberg," said study senior author Dr. Herbert Virgin IV, a professor of pathology and head of the department of pathology and immunology at Washington University School of Medicine in St. Louis. Much more research is ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis

Crohn's, Colitis May Have Genetic Underpinnings, Study Finds

Posted 19 Dec 2014 by Drugs.com

FRIDAY, Dec. 19, 2014 – The intestinal bacteria that cause inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, may be inherited, researchers report. The findings, published recently in the journal Genome Medicine, could help in efforts to prevent the disease and treat the 1.6 million Americans with Crohn's or colitis, the study authors added. "The intestinal bacteria, or 'gut microbiome,' you develop at a very young age can have a big impact on your health for the rest of your life," lead author Dan Knights, an assistant professor in the department of computer science and engineering and the Biotechnology Institute at the University of Minnesota, said in a journal news release. "We have found groups of genes that may play a role in shaping the development of imbalanced gut microbes," he explained. The study of 474 adults with inflammatory bowel disease ... Read more

Related support groups: Crohn's Disease, Inflammatory Bowel Disease, Pseudomembranous Colitis

Scientists Grow, Implant Human Intestinal Tissue in Mice

Posted 20 Oct 2014 by Drugs.com

SUNDAY, Oct. 19, 2014 – New stem cell-based research could improve understanding of intestinal diseases and eventually lead to new treatments, a new study suggests. Scientists used stem cells to grow "organoids" of functioning human intestinal tissue in a lab dish. They then transplanted the organoids into mice, creating a new model for studying intestinal disorders, according to the researchers. "This provides a new way to study the many diseases and conditions that can cause intestinal failure, from genetic disorders appearing at birth to conditions that strike later in life, such as cancer and Crohn's disease," lead investigator Dr. Michael Helmrath, surgical director of the Intestinal Rehabilitation Program at the Cincinnati Children's Hospital Medical Center, said in a center news release. "These studies also advance the longer-term goal of growing tissues that can replace damaged ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Certain Autoimmune Drugs in Pregnancy May Up Newborn Infection Risk: Study

Posted 3 Oct 2014 by Drugs.com

FRIDAY, Oct. 3, 2014 – When given to pregnant women, a common treatment for ulcerative colitis may inadvertently lower their baby's ability to fight off infections at birth, new French research suggests. The treatment, called anti-TNF therapy, is an injected, artificial antibody. This type of medication is widely seen as a safe and effective way to tackle a wide range of autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel conditions that include ulcerative colitis and Crohn's disease. It's not unusual for pregnant women to receive the treatment, given that inflammatory bowel diseases often strike women of childbearing age. However, this type of drug can cross the placenta and reach the fetus, the study authors said. And four French cases – all involving babies born to women exposed to Remicade (infliximab) during pregnancy – suggest the therapy may cause newborn ... Read more

Related support groups: Rheumatoid Arthritis, Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Cimzia, Inflammatory Bowel Disease, Simponi, Infliximab, Etanercept, Adalimumab, Golimumab, Certolizumab

FDA Approves Humira (adalimumab) for the Treatment of Pediatric Patients with Crohn's Disease

Posted 26 Sep 2014 by Drugs.com

NORTH CHICAGO, Ill., Sept. 25, 2014 /PRNewswire/ – AbbVie announced today that the U.S. Food and Drug Administration (FDA) has approved Humira (adalimumab) for reducing signs and symptoms, and achieving and maintaining clinical remission, in pediatric Crohn's disease patients 6 years of age and older when certain other treatments have not worked well enough. This FDA approval represents the eighth indication for Humira in the United States and makes it the first and only biologic treatment approved for use in this patient population that can be administered at home. "Moderate to severe Crohn's disease is a serious chronic disorder that can impact children and adolescents in significant ways during this important stage of their lives," said Jeffrey S. Hyams, M.D., head, Division of Digestive Diseases, Hepatology and Nutrition, Connecticut Children's Medical Center. "The approval of ... Read more

Related support groups: Humira, Crohn's Disease, Adalimumab

Scientists Spot Genetic Clues to Crohn's Disease

Posted 27 Aug 2014 by Drugs.com

WEDNESDAY, Aug. 27, 2014 – A new genetic discovery about Crohn's disease could lead to different ways to fight the bowel disorder, researchers report. The scientists pinpointed chemical changes in Crohn's patients' DNA that affect how their genes work, and said these changes can be detected in blood samples. Along with raising the possibility of a simple diagnostic test for Crohn's, the findings provide new insight into how the disease develops and suggest possible gene targets for new treatments, said the authors of the study. It was published Aug. 26 in the journal Inflammatory Bowel Diseases. Previous research has found several genes linked to Crohn's, but not everyone who has the genes develops the condition. The findings of this new study involving children with Crohn's disease in Scotland suggest that differences in environmental factors among people – such as diet and gut ... Read more

Related support groups: Crohn's Disease

Popular Crohn's, Colitis Drugs Not Linked to Short-Term Cancer Risk: Study

Posted 18 Jun 2014 by Drugs.com

WEDNESDAY, June 18, 2014 – A popular class of drugs used to treat inflammatory bowel disease isn't linked to an increase in the short-term risk of cancer, Danish researchers report. Researchers found that people with Crohn's disease or colitis who received the drugs – tumor necrosis factor alpha (TNF-a) antagonists – had about the same risk of cancer as other people with these inflammatory bowel diseases who were not treated with the medication. The drugs work by interrupting the function of TNF-a, a substance used by the immune system to increase inflammation. "Treatment with these drugs inhibits the inflammatory response in the gastrointestinal tract thereby leading to reduced symptoms," said lead author Dr. Nynne Nyboe Andersen of the Statens Serum Institute in Copenhagen. The problem is that TNF-a also serves a key role in protecting the body against cancer, raising concerns that ... Read more

Related support groups: Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Colorectal Cancer, Cimzia, Inflammatory Bowel Disease, Simponi, Infliximab, Etanercept, Adalimumab, Golimumab, Certolizumab

FDA OKs New Drug for Hard-to-Treat Colitis and Crohn's

Posted 21 May 2014 by Drugs.com

WEDNESDAY, May 21, 2014 – A new drug to treat adults with ulcerative colitis and Crohn's disease has been approved by the U.S. Food and Drug Administration. The agency said Tuesday that injections of Entyvio (vedolizumab) can be used to treat patients with moderate to severe ulcerative colitis and Crohn's disease who have had poor responses to one or more of the current standard therapies: corticosteroids, immunomodulators, or tumor necrosis factor blocker medications. The FDA's approval of the new drug is based on two clinical trials of about 900 patients with ulcerative colitis, and three clinical trials of about 1,500 patients with Crohn's disease. Ulcerative colitis causes inflammation and ulcers in the inner lining of the large intestine and can lead to abdominal discomfort, bleeding and diarrhea. It affects about 620,000 Americans. Crohn's can cause inflammation and irritation in ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis

Entyvio Approved for Ulcerative Colitis and Crohn's Disease

Posted 20 May 2014 by Drugs.com

TUESDAY, May 20, 2014 – Entyvio (vedolizumab) has been approved by the U.S. Food and Drug Administration to treat adults with moderate-to-severe forms of two gastrointestinal conditions – ulcerative colitis and Crohn's disease. The approval applies to people for whom standard therapies – such as corticosteroids or tumor necrosis factor-blocking medications – have failed. Ulcerative colitis, affecting about 620,000 Americans, causes inflammation and ulcers in the large intestine. This can lead to abdominal discomfort, bleeding and diarrhea, the FDA said in a news release. Crohn's causes inflammation and irritation of any part of the gastrointestinal tract. More than 500,000 Americans have been diagnosed with Crohn's, the FDA said. The most common side effects of Entyvio include headache, joint pain, nausea and fever. More serious adverse reactions observed during clinical testing ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance

FDA Approves Entyvio (vedolizumab) to treat Ulcerative Colitis and Crohn's Disease

Posted 20 May 2014 by Drugs.com

May 20, 2014 – The U.S. Food and Drug Administration today approved Entyvio (vedolizumab) injection to treat adult patients with moderate to severe ulcerative colitis and adult patients with moderate to severe Crohn‘s disease. Entyvio is approved to treat those conditions when one or more standard therapies (corticosteroids, immunomodulators, or tumor necrosis factor blocker medications) have not resulted in an adequate response. Ulcerative colitis is a chronic disease that affects about 620,000 Americans. It causes inflammation and ulcers in the inner lining of the large intestine and is one of two main forms of chronic inflammatory bowel disease. The inflammation can lead to abdominal discomfort, gastrointestinal bleeding, and diarrhea. Crohn‘s disease is a chronic inflammatory condition that causes inflammation, or swelling, and irritation of any part of the digestive tract—also c ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis

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