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White Men May Get Better Treatment for Abnormal Heartbeat

Posted 2 days 13 hours ago by Drugs.com

TUESDAY, June 30, 2015 – Women, Hispanics and blacks are less likely than white men to receive optimal treatment for atrial fibrillation in the United States, researchers say. The study of more than a half-million Medicare patients found that women with this abnormal heart rhythm are less likely than men to get blood thinners to prevent stroke, which is a serious risk with atrial fibrillation. Women, blacks and Hispanics are also less likely to get catheter ablation, a surgical procedure that can restore the heart's normal rhythm. "Across the board, women are offered less aggressive care, particularly in cardiology," said lead researcher Dr. Prashant Bhave, a clinical assistant professor of internal medicine at University of Iowa Health Care. "There are still gaps in how patients are treated," he said. "The most important one is the difference in prescribing blood thinners. Ablation ... Read more

Related support groups: Warfarin, Coumadin, Atrial Fibrillation, Xarelto, Pradaxa, Lovenox, Heparin, Prevention of Thromboembolism in Atrial Fibrillation, Eliquis, Rivaroxaban, Enoxaparin, Clexane, Fragmin, Arixtra, Thromboembolic Stroke Prophylaxis, Hep-Pak, Apixaban, Fondaparinux, Dalteparin, Dabigatran

Drug May Be Antidote to Bleeding Tied to Blood Thinner Pradaxa

Posted 11 days ago by Drugs.com

MONDAY, June 22, 2015 – The new blood thinner Pradaxa (dabigatran) is being widely used, but it comes with one serious drawback: rare but dangerous cases of sudden, uncontrolled bleeding in patients. Now, a new study finds than an experimental, injected drug called idarucizumab could be used to quickly stop that bleeding. "Idarucizumab completely reversed the anticoagulant [bleeding] effect of dabigatran within minutes," researchers say in a study published online June 22 in the New England Journal of Medicine. In recent years, new-generation blood thinners such as Pradaxa have been approved as more manageable alternatives to older drugs such as warfarin. Unlike warfarin, these drugs "do not require blood tests for monitoring... while offering similar results in terms of effectiveness," explained Dr. Kevin Marzo, chief of cardiology at Winthrop-University Hospital in Mineola, N.Y. ... Read more

Related support groups: Warfarin, Coumadin, Atrial Fibrillation, Pradaxa, Transient Ischemic Attack, Prosthetic Heart Valves, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Mechanical Valves, Atrial Flutter, Ischemic Stroke - Prophylaxis, Thrombotic/Thromboembolic Disorder, Thromboembolic Stroke Prophylaxis, Prosthetic Heart Valves - Tissue Valves, Myocardial Infarction - Prophylaxis, Dabigatran, Jantoven, Valvular Heart Disease, Mitral Stenosis, Miradon, Bivalirudin

Blood Thinners OK for Cancers That Spread to Brain, Study Finds

Posted 2 Jun 2015 by Drugs.com

TUESDAY, June 2, 2015 – Blood-thinning drugs are safe for treating blood clots in patients with cancer that has spread to the brain from other areas of the body, according to new research. Cancer normally increases a person's risk of blood clots, the study authors explained in a news release from the American Society of Hematology. When a cancer patient develops a clot, a blood thinner – also called an anticoagulant – is often added to the cancer treatment regimen to prevent the risk of blood clots traveling to the lungs. Such a clot can be fatal. However, if cancer spreads from other parts of the body to the brain (called brain metastases), doctors are hesitant to prescribe blood thinners because of concern they might cause bleeding in the head, which is already a risk for these patients, the study authors added. The new findings show that the use of blood thinners in these patients ... Read more

Related support groups: Cancer, Warfarin, Coumadin, Xarelto, Pradaxa, Lovenox, Heparin, Brain Tumor, Eliquis, Rivaroxaban, Enoxaparin, Clexane, Fragmin, Arixtra, Hep-Pak, Apixaban, Fondaparinux, Tinzaparin, Dabigatran, Dalteparin

Blood Thinner Warfarin May Pose Greater Bleeding Risk for Obese: Study

Posted 8 May 2015 by Drugs.com

FRIDAY, May 8, 2015 – Obese patients taking the blood thinner warfarin appear to have almost twice the risk of severe stomach bleeding compared to their normal-weight counterparts, a new study suggests. Why obese patients may be at greater risk for stomach bleeding isn't clear, according to the study. But Dr. Richard Hayes, a cardiologist at Lenox Hill HealthPlex in New York City, said it isn't surprising that obese patients taking warfarin may have a higher risk for stomach bleeding. "Obese patients have more medical problems, such as high blood pressure and diabetes," he said. "Therefore, they are more likely to be on other medications, many of which interfere with warfarin." Hayes was not involved in the new research, but reviewed the study's findings. Warfarin is taken to prevent heart attacks and stroke. It is often prescribed for patients with atrial fibrillation – an abnormal ... Read more

Related support groups: Obesity, Warfarin, Coumadin, Atrial Fibrillation, Prevention of Thromboembolism in Atrial Fibrillation, Jantoven, Gastrointestinal Hemorrhage, Anisindione, Miradon, Upper GI Hemorrhage, Dicumarol

Pharmacists Key to Whether Patients Take Blood Thinners

Posted 14 Apr 2015 by Drugs.com

TUESDAY, April 14, 2015 – Millions of older Americans are prescribed a blood thinner to help reduce the stroke risks associated with a dangerous irregular heart beat known as atrial fibrillation. A new study finds that even though a large percentage fail to take the potentially life-saving medications as prescribed, the intervention of their local pharmacist might help. In the study, a team led by Dr. Mintu Turakhia, an assistant professor of medicine at Stanford University, in Palo Alto, Calif., looked at the use of the blood thinner Pradaxa (dabigatran) by Veterans Administration outpatients who were prescribed the drug between 2010 and 2012. Pradaxa belongs to a new class of twice-daily oral blood thinners, and it is often prescribed for atrial fibrillation (nicknamed "a-fib"). "The new oral anticoagulants, such as dabigatran, represent the biggest medical change in the delivery of ... Read more

Related support groups: Warfarin, Coumadin, Atrial Fibrillation, Xarelto, Prevention of Thromboembolism in Atrial Fibrillation, Eliquis, Rivaroxaban, Arixtra, Apixaban, Fondaparinux, Jantoven, Savaysa, Edoxaban, Dicumarol, Arixtra 5 mg/dose, Miradon, Anisindione, Arixtra 10 mg/dose, Arixtra 7.5 mg/dose

Blood Thinners Overprescribed for Low-Risk Irregular Heartbeat: Study

Posted 14 Apr 2015 by Drugs.com

TUESDAY, April 14, 2015 – As many as one-quarter of people with atrial fibrillation who have a low risk of stroke are given blood-thinning drugs they likely don't need, a new study contends . Atrial fibrillation – a common form of irregular heartbeat – can cause blood clots. Those blood clots can then travel to the brain and cause a stroke. To prevent this from happening, many people with atrial fibrillation are prescribed blood thinners. However, because the drugs also have a risk of causing excessive bleeding, they generally aren't recommended for people with atrial fibrillation who have the lowest risk for stroke, the study authors explained. The study included information from nearly 11,000 atrial fibrillation patients across the United States. They were all younger than 60. They were also all considered to have a low risk of stroke, according to the researchers. Still, the study ... Read more

Related support groups: Warfarin, Coumadin, Atrial Fibrillation, Xarelto, Eliquis, Rivaroxaban, Arixtra, Apixaban, Fondaparinux, Jantoven, Edoxaban, Savaysa, Dicumarol, Arixtra 5 mg/dose, Miradon, Anisindione, Arixtra 10 mg/dose, Arixtra 7.5 mg/dose

Could Too Much Medication for Irregular Heartbeat Raise Dementia Risk?

Posted 16 Nov 2014 by Drugs.com

SUNDAY, Nov. 16, 2014 – People with atrial fibrillation who are overtreated with anti-clotting drugs may be doubling their risk for dementia, a new study suggests. Atrial fibrillation causes the upper chambers of the heart to contract quickly and irregularly. These abnormal contractions allow blood to pool in the heart, forming clots that can cause a stroke if they break off and are carried into the brain. However, too much anti-clotting medication may raise the chances of tiny brain bleeds that, over time, might raise the risk of dementia, the researchers said. "In patients with atrial fibrillation, dementia risk is dependent on the efficacy and control of long-term use of anti-clotting drugs," said lead researcher Dr. Thomas Jared Bunch, director of electrophysiology at the Intermountain Heart Institute in Murray, Utah. Warfarin and Plavix, along with aspirin, are some of the most ... Read more

Related support groups: Warfarin, Coumadin, Plavix, Atrial Fibrillation, Dementia, Clopidogrel, Prevention of Thromboembolism in Atrial Fibrillation, Jantoven

Study: Aspirin Might Work Instead of Warfarin for Deep Vein Clots

Posted 26 Aug 2014 by Drugs.com

TUESDAY, Aug. 26, 2014 – Aspirin may offer an alternative for people who've had blood clots in the deep veins of the legs and can't tolerate long-term use of blood thinners, according to Australian researchers. The condition, called deep vein thrombosis (DVT), can be life-threatening if clots break loose, travel to the lungs and block a pulmonary artery. Patients are usually prescribed blood thinners such as warfarin to prevent clot formation, the researchers noted. "Most people who have had a blood clot in a leg vein or an embolism where the clot blocks the blood flow have anticoagulant drug treatment, such as warfarin, for at least six months, first to dissolve the clot and then to prevent it happening again," said lead researcher Dr. John Simes, a professor of medicine at the University of Sydney. However, long-term use of warfarin (Coumadin) can be inconvenient, requiring frequent ... Read more

Related support groups: Aspirin, Warfarin, Coumadin, Xarelto, Deep Vein Thrombosis (DVT), Pradaxa, Deep Vein Thrombosis, Rivaroxaban, Ecotrin, Bayer Aspirin, Bufferin, Jantoven, Dabigatran, Ascriptin, Low Dose ASA, Aspergum, Buffered Aspirin, Aspir-Low, St Joseph Aspirin, Aspirin Low Strength

FDA Medwatch Alert: Coumadin (warfarin sodium) for Injection by Bristol-Myers Squibb: Recall - Particulate Matter

Posted 3 Jul 2014 by Drugs.com

ISSUE:  Bristol-Myers Squibb Company issued a voluntary recall of six lots of Coumadin for Injection, 5 mg single-use vials in the U.S. Visible particulate matter was found in a small number of Coumadin for Injection unreleased samples. Injected particulate metallic and non-metallic cellulose material can cause serious and potentially fatal adverse reactions such as embolization. Allergic reactions to the foreign material could also occur. To date, there have been no product complaints or adverse events reported to Bristol-Myers Squibb related to this issue. Coumadin for Injection 5 mg single-use vials is packaged in cartons of six vials. The affected Coumadin for Injection includes the following six lots distributed to hospitals and pharmacies from November 2011 through January 2014: 201125, 201126, 201127, 201228, 201229, 201230. BACKGROUND: Coumadin for Injection was discontinued in ... Read more

Related support groups: Warfarin, Coumadin, Pulmonary Embolism, Jantoven

Doctors' Groups Issue New Guidelines on Treating Common Irregular Heartbeat

Posted 28 Mar 2014 by Drugs.com

FRIDAY, March 28, 2014 – Reduced use of aspirin and the addition of three new blood thinners as treatment options are among the recommendations in updated guidelines to manage a heart rhythm disorder called atrial fibrillation, which is a major risk factor for stroke. According to the American Heart Association, atrial fibrillation involves rapid and disorganized electrical signals that cause the heart's two upper chambers – the atria – to contract rapidly and irregularly. Symptoms can include rapid and irregular heartbeat, heart palpitations, shortness of breath, dizziness, sweating, fatigue or chest pain. Atrial fibrillation is not a fatal condition, but it can increase a person's risk of stroke five-fold. That's because atrial fibrillation allows blood to pool in the atria and form clots, the AHA said. One study published in November at the AHA's annual meeting found that ... Read more

Related support groups: Aspirin, Warfarin, Coumadin, Atrial Fibrillation, Xarelto, Pradaxa, Prevention of Thromboembolism in Atrial Fibrillation, Eliquis, Rivaroxaban, Ecotrin, Bayer Aspirin, Apixaban, Bufferin, Jantoven, Dabigatran, Low Dose ASA, Aspergum, Buffered Aspirin, St Joseph Aspirin, Aspirin Low Strength

Warfarin Safe for Kidney Patients With Irregular Heartbeat: Study

Posted 4 Mar 2014 by Drugs.com

TUESDAY, March 4, 2014 – People with chronic kidney disease who take the blood thinner warfarin to treat a form of irregular heartbeat are at no greater risk for stroke or death than similar patients who don't take the medicine, researchers report. The Swedish study involved more than 24,000 people diagnosed with heart disease and atrial fibrillation, a common and dangerous form of irregular heartbeat. In atrial fibrillation, blood pools in the heart's chambers, raising the risk for stroke. Researchers led by Juan Jesus Carrero of the Karolinska Institute in Stockholm examined the link between treating atrial fibrillation with a blood thinner and patients' kidney function. The study, published in the March 5 issue of the Journal of the American Medical Association, found that taking warfarin was associated with a lower one-year risk of death, heart attack or stroke combined, without ... Read more

Related support groups: Warfarin, Coumadin, Prevention of Thromboembolism in Atrial Fibrillation, Jantoven

Warfarin May Up Stroke Risk in Those With Irregular Heartbeat: Study

Posted 19 Dec 2013 by Drugs.com

WEDNESDAY, Dec. 18, 2013 – Many older Americans take the blood thinner warfarin to help guard against heart trouble. However, a new study suggests use of the drug is tied to a temporary spike in the risk of stroke for people with a common heart rhythm disorder. People with the irregular heart beat known as atrial fibrillation had nearly double the odds of suffering a stroke in the month after they started taking warfarin, compared to similar patients who weren't taking the medication, researchers report. The findings seem counterintuitive, since many people with atrial fibrillation are placed on warfarin to help lessen their odds for a stroke, the researchers noted. However, prior studies have suggested that there may be an initial period of heightened risk after people move from other drugs to warfarin. Patients who are new to warfarin might also experience a temporary state of ... Read more

Related support groups: Warfarin, Coumadin, Prevention of Thromboembolism in Atrial Fibrillation, Jantoven

Studies Suggest Better Approaches to Staying Clot-Free

Posted 19 Nov 2013 by Drugs.com

TUESDAY, Nov. 19, 2013 – Genetic testing could help better guide doctors' use of warfarin, new research suggests. The blood-thinning medication is widely used to prevent stroke and heart attack in people with irregular heartbeats. Warfarin is a popular medication, but a tricky one to use, the researchers said. Patients who receive too strong a dose can suffer from unusual and excessive bleeding, potentially coughing up or vomiting blood, according to the American Heart Association (AHA). But doctors who used genetic testing to guide patients' warfarin doses were better able to quickly reach and consistently remain within the drug's therapeutic "sweet spot," according to the study. It was published in the Nov. 19 online edition of the New England Journal of Medicine and presented Tuesday at the AHA's annual meeting in Dallas. "[Blood-thinning] therapy is difficult and it's associated ... Read more

Related support groups: Warfarin, Coumadin, Prevention of Thromboembolism in Atrial Fibrillation, Jantoven

FDA Medwatch Alert: Warfarin 2 mg Tablets by Zydus Pharmaceuticals USA Inc.: Recall - Due to Oversized Tablets

Posted 12 Jun 2013 by Drugs.com

ISSUE: Zydus Pharmaceuticals USA Inc. is voluntarily recalling one lot of Warfarin 2 mg Tablets, Lot #MM5767, expiration date June 2014 to the retail level. Four tablets of Warfarin 2 mg Tablets, Lot MM5767, have been found to be oversized in one product complaint. Ingestion of a greater than intended dose of Warfarin, could lead to an increased pharmacological effect of warfarin. As a result, patients would be more likely to develop bleeding as an adverse reaction and in some patients that bleeding into a critical organ (mostly the central nervous system) could be fatal. The risk of bleeding is increased if overdosing is repeated continuously on a daily basis. BACKGROUND:  The product is used as prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE), prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation (AF) ... Read more

Related support groups: Warfarin, Coumadin, Jantoven

Blacks With Certain Gene Need Lower Doses of Warfarin: Study

Posted 5 Jun 2013 by Drugs.com

WEDNESDAY, June 5 – The discovery of a genetic variation that affects how some black patients respond to the blood thinner warfarin could improve the safety and effectiveness of the drug, researchers report. Blacks with this common genetic variation need a significantly lower dose of warfarin than those without the variation, the researchers report online June 4 in The Lancet. "Adding this genetic marker – found in more than 40 percent of African-American patients in the study – to standard dosing algorithms improved the predictability of warfarin dosing by 21 percent in these individuals, which has the potential to increase the safety and effectiveness of this notoriously hard-to- dose drug," study leader Julie Johnson, of the University of Florida, said in a journal news release. Warfarin is widely used to prevent blood clots in patients with a heart rhythm disorder called atrial ... Read more

Related support groups: Warfarin, Coumadin, Jantoven

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