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Related terms: Coagulopathy, Consumption coagulopathy, Disseminated Intravascular Coagulation (DIC), DIC

Seniors More Likely to Wind Up in Hospital After Outpatient Surgery: Study

Posted 25 Aug 2015 by

TUESDAY, Aug. 25, 2015 – Seniors are much more likely than younger people to find themselves in the hospital after outpatient surgery, a new study finds. "These seniors were supposed to stay out of the hospital since the procedures were performed in the ambulatory setting, but they were admitted to the hospital within 30 days," corresponding study author Dr. Gildasio De Oliveira Jr., an assistant professor in the Center for Healthcare Studies at Northwestern University's Feinberg School of Medicine in Chicago, said in a university news release. "Age was the biggest factor associated with readmission and complications. It's not because they are sicker, it's because they are older and have trouble understanding their discharge instructions and medication dosing, which often are not clearly explained," he said. Researchers analyzed data from more than 53,000 Americans who underwent ... Read more

Related support groups: Infections, Surgery, Bleeding Disorder, Influenza, Blood Transfusion, Postoperative Infection

Study Sees No Link Between Testosterone Therapy and Blood Clots

Posted 20 Jul 2015 by

MONDAY, July 20, 2015 – Testosterone therapy doesn't appear to increase the risk of blood clots in veins, a new study contends. The most common forms of this problem – called venous thromboembolism (VTE) – are deep vein thrombosis (a clot in the leg) and pulmonary embolism (a clot in the lungs). VTE is the third most common type of cardiovascular problem, after heart attack and stroke, the researchers said. There is conflicting information about the link between testosterone therapy and the risk of VTE. As a result, many men with low testosterone and their doctors are reluctant to start testosterone therapy, the study investigators said. "In 2014, the [U.S.] Federal Drug Administration required manufacturers to add a warning about potential risks of VTE to the label of all approved testosterone products," study author Jacques Baillargeon, a professor of epidemiology at the University ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Testosterone, AndroGel, Testim, Axiron, Androderm, Depo-Testosterone, Testopel, Fortesta, Testopel Pellets, Aveed, Testim 5 g/packet, Coagulation Defects and Disorders, Delatestryl, Striant, AndroGel 1.25 g/actuation, Delatestadiol, FIRST-Testosterone MC, Andro-Cyp 200

Antidepressant, Painkiller Combo May Raise Risk of Brain Bleed

Posted 14 Jul 2015 by

TUESDAY, July 14, 2015 – Taking both an antidepressant and a painkiller such as ibuprofen or naproxen may increase risk of a brain hemorrhage, a new study suggests. Korean researchers found that of more than 4 million people prescribed a first-time antidepressant, those who also used nonsteroidal anti-inflammatory drugs (NSAIDs) had a higher risk of intracranial hemorrhage within the next month. Intracranial hemorrhage refers to bleeding under the skull that can lead to permanent brain damage or death. The findings, published online July 14 in BMJ, add to a week of bad news on NSAIDs, which include over-the-counter pain relievers such as aspirin, ibuprofen (Motrin, Advil) and naproxen (Aleve). Last Thursday, the U.S. Food and Drug Administration strengthened the warning labels on some NSAIDs, emphasizing that the drugs can raise the risk of heart attack and stroke. As far as the new ... Read more

Related support groups: Lexapro, Zoloft, Cymbalta, Wellbutrin, Bleeding Disorder, Effexor, Prozac, Celexa, Paxil, Citalopram, Trazodone, Pristiq, Sertraline, Ibuprofen, Viibryd, Amitriptyline, Naproxen, Bupropion, Fluoxetine, Effexor XR

Anti-Vaccine Trend Has Parents Shunning Newborns' Vitamin Shot

Posted 6 Jul 2015 by

MONDAY, July 6, 2015 – With the recent U.S. measles outbreak, the issue of vaccine refusal has received growing scrutiny. Now doctors are calling attention to a similar problem: Some parents are shunning the vitamin K shot routinely given to newborns to prevent internal bleeding. The consequences of that choice can be severe, pediatric specialists say. Infants can quickly become deficient in vitamin K, which can lead to dangerous bleeding in the intestines or the brain. "If you refuse the shot, you're rolling the dice with your child's health," said Dr. Robert Sidonio Jr., a hematologist and assistant professor of pediatrics at Emory University in Atlanta. Vitamin K is necessary for normal blood clotting. In older children and adults, bacteria in the gut produce much of the vitamin K the body needs. But that's not the case for infants. And breast milk does not supply enough vitamin K ... Read more

Related support groups: Bleeding Disorder, Delivery, Coagulation Defects and Disorders, Vaccination and Prophlaxis, Bleeding Associated with Coagulation Defect

Researchers Report Progress in Making All Blood Types Universally Accepted

Posted 21 May 2015 by

THURSDAY, May 21, 2015 – Scientists are closing in on a way to transform any type of donated blood into type O, the universal blood type that can safely be given to any patient. Researchers have created a special enzyme that can shear off the substances on red blood cells that are responsible for potentially fatal immune reactions if a patient receives the wrong type of blood, according to a new study. The enzyme is not yet effective enough to allow for large-scale processing to convert type A or type B blood into type O, said lead author David Kwan, a postdoctoral fellow of chemistry at the University of British Columbia's Centre for Blood Research in Vancouver, Canada. "We're not there yet. This is really a step towards that," Kwan said. "The big thing is that we've shown that it's feasible to improve these enzymes." Results of the study were published online recently in the Journal ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Anemia, Blood Transfusion, Anemia Prior to Surgery, Exchange Transfusion, Blood Cell Transplantation

Does Long-Term Acetaminophen Use Raise Health Risks?

Posted 3 Mar 2015 by

MONDAY, March 2, 2015 – Acetaminophen may not be as safe as previously thought, with larger doses and long-term use linked to increased risk of health problems, a new report contends. Best known in the United States under the brand name Tylenol, acetaminophen is the most widely used painkiller in the world, the study authors said in background notes. It is the World Health Organization's front-line treatment for pain, and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen, the researchers said. But a small group of studies has raised questions about acetaminophen's safety if used for a long time and at high doses to treat chronic pain, said lead author Dr. Philip Conaghan, a professor with the Leeds Institute of Rheumatic and Musculoskeletal Medicine in England. Heavy use of acetaminophen is associated with kidney disease and bleeding ... Read more

Related support groups: High Blood Pressure, Percocet, Vicodin, Bleeding Disorder, Norco, Hypertension, Lortab, Tylenol, Ischemic Stroke, Acetaminophen, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, NyQuil, Tylenol PM, Acetaminophen/Hydrocodone, Tylenol with Codeine, Chronic Kidney Disease

Tretten Approved for Genetic Clotting Disorder

Posted 23 Dec 2013 by

MONDAY, Dec. 23, 2013 – Tretten (coagulation factor XIII A-Subunit recombinant) has been approved by the U.S. Food and Drug Administration to treat a very rare blood clotting disorder called congenital Factor XIII A-Subunit deficiency. People with the genetic disorder do not make enough Factor XIII, a blood component that promotes clotting. Tretten, a human recombinant produced in yeast cells, makes up for this deficiency, which could otherwise be life threatening, the FDA said Monday in a news release. Tretten was evaluated in a clinical study of 77 people with the disorder. Administered monthly, it was effective in preventing bleeding in 90 percent of recipients. Side effects included headache, extremity pain and pain at the injection site. No study participant developed abnormal clotting, the FDA said. The product was developed and is produced by Novo Nordisk, based in Denmark. More ... Read more

Related support groups: Bleeding Disorder

Later Clamping of Umbilical Cord May Benefit Newborns: Study

Posted 11 Jul 2013 by

THURSDAY, July 11 – Doctors may be clamping umbilical cords too soon after a baby's birth, according to a new study. Doctors routinely clamp and sever the umbilical cord less than a minute after birth, a practice believed to lower the risk of severe bleeding in the mother. But this new study found that delaying clamping for at least a minute after birth allows more time for blood to move from the placenta and helps boost iron stores and hemoglobin levels in newborns, without increasing the risks to mothers, The New York Times reported Thursday. Compared with babies who had early clamping, those who had delayed clamping had higher hemoglobin levels 24 to 48 hours after birth and were less likely to be iron deficient three to six months after birth, the Times reported. Later clamping did not increase the mothers' risk of severe bleeding after birth, blood loss or reduced hemoglobin ... Read more

Related support groups: Bleeding Disorder

FDA Approves Kcentra for the Urgent Reversal of Anticoagulation in Adults with Major Bleeding

Posted 6 May 2013 by

April 29, 2013 – The U.S. Food and Drug Administration today approved Kcentra (Prothrombin Complex Concentrate, Human) for the urgent reversal of vitamin K antagonist (VKA) anticoagulation in adults with acute major bleeding. Plasma is the only other product approved for this use in the United States. Patients receiving chronic anticoagulation therapy with warfarin and other VKA anticoagulants to prevent blood clotting in conditions such as atrial fibrillation or the presence of an artificial heart valve sometimes develop acute bleeding. Like plasma, Kcentra is used in conjunction with the administration of vitamin K to reverse the anticoagulation effect and stop the bleeding. Unlike plasma, Kcentra does not require blood group typing or thawing, so it can be administered more quickly than frozen plasma. “The FDA’s approval of this new product gives physicians a choice when deciding h ... Read more

Related support groups: Bleeding Disorder

Major Bleeds After Heart Procedures May Raise Death Risk: Study

Posted 12 Mar 2013 by

TUESDAY, March 11 – Patients with major bleeding after procedures to open blocked heart arteries are at significantly increased risk for death, according to a new study. Researchers analyzed data from 3.3 million percutaneous coronary interventions (balloon angioplasty and stent-placement procedures) performed in the United States between 2004 and 2011. The study found that 1.7 percent of the patients had major bleeding after their procedure and 0.65 percent of them died in the hospital. The in-hospital death rate for patients with major bleeding was 5.3 percent, compared with 1.9 percent for those without bleeding. After taking other factors into account, the researchers calculated that patients with major bleeding after percutaneous coronary intervention had about a 12 percent increased risk of in-hospital death, according to the study, which was published in the March 13 issue of ... Read more

Related support groups: Bleeding Disorder

Fraudulent Data May Have Led to Use of Risky Treatment in ICUs

Posted 19 Feb 2013 by

TUESDAY, Feb. 19 – Studies loaded with fraudulent data may have encouraged the use of a treatment for patients in intensive care units that now appears to do more harm than good, new research shows. At issue is hydroxyethyl starch, an intravenous solution sometimes used to replace lost blood volume in critically ill patients. According to a new review article in the Feb. 20 issue of the Journal of the American Medical Association, the starchy solution may instead boost their risk of death or kidney failure. "Almost certainly, what is happening is that some of the starch molecules leak out of blood vessels into the kidney itself so the kidney doesn't work as efficiently," said Dr. David Taylor, chairman of pulmonary and critical care medicine at Ochsner Health System in New Orleans. He was not involved in the new review. Luckily for American patients, hydroxyethyl starch is not commonly ... Read more

Related support groups: Bleeding Disorder

Octaplas Approved for Blood-Clotting Disorders

Posted 17 Jan 2013 by

THURSDAY, Jan. 17 – Octaplas has been approved by the U.S. Food and Drug Administration to augment insufficient clotting proteins that could otherwise lead to excessive bleeding or excessive clotting. The product is a sterile, frozen solution made from human plasma. A "solvent detergent process" is applied to minimize the possibility of serious viral transmission, the agency said. Octaplas should be matched to the recipient's blood type to help avoid transfusion reactions. Each lot is measured for the required presence of clotting factors before the lot is approved for use, the FDA said. The current version has been used in Europe and elsewhere since 2006, and a prior formulation was first used in 1992. In all, more than 2 million people have been treated with more than 7 million doses outside the United States, the agency said. Clinical testing of Octaplas focused on people with liver ... Read more

Related support groups: Bleeding Disorder

Health Tip: What's Behind Your Nosebleed

Posted 21 Dec 2012 by

-- Nosebleeds affect one in seven people during their lives, the American Academy of Otolaryngology says. They're most common among people aged 2-10, and aged 50-80. The academy says the most common causes of nosebleeds include: Dryness, allergies or infections. Blowing your nose too hard. A blood clotting problem triggered by heredity or a current medication. A skull fracture or fracture of the nose. Tumors or hereditary blood vessel disorders. Read more

Related support groups: Bleeding Disorder

FDA Approves Corifact to Prevent Bleeding in People With Rare Genetic Defect

Posted 21 Feb 2011 by

SILVER SPRING, Md., Feb. 17, 2011 /PRNewswire-USNewswire/ – The U.S. Food and Drug Administration today approved Corifact, the first product intended to prevent bleeding in people with the rare genetic defect congenital Factor XIII deficiency. Patients with congenital Factor XIII deficiency don't make enough Factor XIII, a substance that circulates in the blood and is important for normal clotting. Without treatment, people with the condition are at risk for life-threatening bleeding. Congenital Factor XIII deficiency is rare and affects 1 out of every 3 million to 5 million people in the United States. The deficiency may lead to soft tissue bruising, mucosal bleeding and fatal intracranial bleeding. Newborns with Factor XIII deficiency may have umbilical cord bleeding. "This product helps fill an important need," said Karen Midthun, M.D., director of the FDA's Center for Biologics ... Read more

Related support groups: Bleeding Disorder, Bleeding Associated with Coagulation Defect

Gene Therapy Corrected Rare Bleeding Disorder: Study

Posted 6 Dec 2010 by

SUNDAY, Dec. 5 – Using gene therapy, German researchers report that they managed to "correct" a malfunctioning gene responsible for Wiskott-Aldrich syndrome, a rare but devastating childhood disorder that leads to prolonged bleeding from even minor hits or scrapes, and also leaves these children vulnerable to certain cancers and dangerous infections. However, one of the 10 kids in the study developed acute T-cell leukemia, apparently as a result of the viral vector that was used to insert the healthy gene. The boy is currently on chemotherapy, the study authors noted. "This is a very good first step, but it's a little scary and we need to move to safer vectors," said Dr. Mary Ellen Conley, director of the Program in Genetic Immunodeficiencies at St. Jude Children's Research Hospital in Memphis, Tenn. "The study shows proof-of-principle that gene therapy with stem cells in a genetic ... Read more

Related support groups: Bleeding Disorder

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