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Related terms: Coagulopathy, Consumption coagulopathy, Disseminated Intravascular Coagulation (DIC), DIC

2 New Findings Offer Hope for Those With Severe Hemophilia

Posted 5 days ago by Drugs.com

WEDNESDAY, May 25, 2016 – Two new studies could pave the way to major changes in how doctors treat severe cases of hemophilia – a rare genetic disorder that can cause uncontrolled bleeding. Both studies tackle a key challenge: Up to one-third of children with severe hemophilia develop antibodies against the standard therapy. But one study highlights the value of an old therapy, while the other shows promising early results with an experimental drug. Experts said both should stir discussion among doctors, patients and parents who deal with hemophilia. But they were especially hopeful about the new drug, known as emicizumab. In the United States, about 20,000 people – mostly boys and men – are living with hemophilia, according to the U.S. Centers for Disease Control and Prevention. The disorder is caused by a defect in one of the genes that controls proteins needed for normal blood ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Anemia, Blood Transfusion, Hemophilia A, Hemophilia, Coagulation Defects and Disorders, Hemophilia B, Blood Cell Transplantation, Hemophilia A with Inhibitors

Is Daily Blood Thinner Needed for Irregular Heartbeat?

Posted 7 May 2016 by Drugs.com

FRIDAY, May 6, 2016 – A smartphone app might offer an alternative for certain patients with an irregular heartbeat who must take risky blood-thinning medication every day to lower their risk for stroke. New research suggests some people with atrial fibrillation might do just as well by diligently monitoring their pulse, perhaps recording their heartbeat via a smartphone EKG, and only taking such drugs on an as-needed basis. Atrial fibrillation is a serious condition characterized by an abnormal or irregular heart rhythm. Uncontrolled, it can lead to blood clotting and stroke. Blood-thinning drugs, called anticoagulants, are the usual treatment. For years, the blood thinner warfarin (Coumadin) has been the top go-to drug for such patients. "The problem is that long-term use of anticoagulants is associated with an increased risk of bleeding," explained study co-author Dr. Francis ... Read more

Related support groups: Bleeding Disorder, Warfarin, Coumadin, Atrial Fibrillation, Arrhythmia, Xarelto, Pradaxa, Eliquis, Prevention of Thromboembolism in Atrial Fibrillation, Rivaroxaban, Apixaban, Dabigatran, Jantoven, Coagulation Defects and Disorders, Reversal of Dabigatran

Health Tip: Donating Blood

Posted 2 May 2016 by Drugs.com

-- Typically, you must be at least 17 years old and meet a few health criteria to donate blood. If you're able, it's a great way to help save lives. The American Red Cross offers this advice on what to expect: One blood donation can help save the lives of three other people. The donation procedure is safe and easy. While the donation itself only takes about 10 minutes, expect to be at the donation center for about an hour. Prepare for donation by making sure you're well-hydrated. Eat a nutritious meal, skipping any foods that are high in fat. Make sure your shirt sleeves can be rolled up above the elbows. Bring your driver's license or a donor ID card. If you're 16 and donating in a state that allows it, bring signed parental consent. Also bring a list of any medications you take. If you're feeling sick beforehand, reschedule the donation. Read more

Related support groups: Blood Disorders, Bleeding Disorder, Anemia, Blood Transfusion, Coagulation Defects and Disorders, Anemia Associated with Chronic Disease, Blood Cell Transplantation

FDA Approves Experimental Zika Test for Blood Donations

Posted 31 Mar 2016 by Drugs.com

WEDNESDAY, March 30, 2016 – An experimental test to check blood donations for the Zika virus has been approved by the U.S. Food and Drug Administration. The decision to allow use of the test in areas with active mosquito-borne transmission of the virus means that collections of whole blood and blood component donations will be able to resume in Puerto Rico, agency officials said. "The availability of an investigational test to screen donated blood for Zika virus is an important step forward in maintaining the safety of the nation's blood supply, especially for those U.S. territories already experiencing active transmission," Dr. Peter Marks, director of the FDA's Center for Biologics Evaluation and Research, said Wednesday. "In the future, should Zika virus transmission occur in other areas, blood collection establishments will be able to continue to collect blood and use the ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Blood Transfusion, Blood Cell Transplantation, Zika Virus Infection

Review Finds Mixed Success With Hemophilia Treatment

Posted 16 Mar 2016 by Drugs.com

WEDNESDAY, March 16, 2016 – Though the past 50 years have brought major treatment advances, men with severe hemophilia are still at high risk for bleeding and physical disability, experts say. Hemophilia is a genetic disease that prevents blood from clotting normally, leading to an increased risk of serious bleeding. More common in men than in women, it affects about one out of every 5,000 men, according to the U.S. Centers for Disease Control and Prevention. Researchers analyzed data from nearly 7,500 male hemophilia patients in the United States between 1998 and 2011. Their findings were published online March 16 in the journal Blood. "Our analysis provides a snapshot of how improvements in care have translated into outcomes across different generations of men with hemophilia," study author Dr. Paul Monahan said in a journal news release. Monahan is a former professor of hematology ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Hemophilia A, Coagulation Defects and Disorders, Hemophilia B, Hemophilia, Hemophilia A with Inhibitors

Could a Clot-Busting Drug Help Treat a 'Bleeding' Stroke?

Posted 18 Feb 2016 by Drugs.com

THURSDAY, Feb. 18, 2016 – In what one expert called a "counterintuitive" finding, research suggests that the powerful clot-busting drug known as tPA might help patients suffering a hemorrhagic ("bleeding") stroke. According to the American Stroke Association, only about 15 percent of strokes are caused by runaway bleeding in the brain; the other 85 percent are caused by a clot. And while it makes sense to use the clot-busting tissue plasminogen activator (tPA) to break up a brain clot, it would seem counterproductive to use the same drug in the case of a bleeding stroke. However, two new studies to be presented Thursday at the stroke association's annual meeting in Los Angeles suggest that tPA may, indeed, have a role to play in the treatment of a bleeding stroke. Both studies were funded by the U.S. National Institutes of Neurological Disorders and Stroke. One study involved 500 ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Ischemic Stroke, Transient Ischemic Attack, Blood Transfusion, Ischemic Stroke - Prophylaxis, Thromboembolic Stroke Prophylaxis, Diagnosis and Investigation, Intracranial Hemorrhage, Streptokinase, Urokinase, Abbokinase Open-Cath, Kinlytic, Abbokinase, Kabikinase, Streptase

The Pill, Hormone Therapy Safe for Women Taking Blood Thinners: Study

Posted 22 Dec 2015 by Drugs.com

TUESDAY, Dec. 22, 2015 – Women on blood thinners can also take contraceptives that contain estrogen, or hormone replacement therapy, without raising their risk for blood clots or uterine bleeding, a new Italian study finds. Currently, women diagnosed with blood clots may be advised to stop hormone therapy or use of the contraceptive pill – even if they are already on a blood thinner. The reason: Doctors are often concerned that these drug combinations might raise the patient's risk for more clots. However, "there has been no evidence to support this decision," said the study's senior author, Dr. Ida Martinelli, of the A. Bianchi Bonomi Hemophilia and Thrombosis Center in Milan. "We conducted this study to address the fear felt by both the physician and patient when making the decision to stop or continue hormone therapy in this setting," she explained in a news release from the ... Read more

Related support groups: Birth Control, Contraception, Blood Disorders, Bleeding Disorder, Emergency Contraception, Warfarin, Coumadin, Hot Flashes, Estradiol, Menopausal Disorders, Xarelto, Premarin, Pradaxa, Ethinyl Estradiol, Estrace, Postcoital Contraception, Lovenox, Postmenopausal Symptoms, Eliquis, Vagifem

FDA Lifts Ban on Blood Donations by Gay Men

Posted 21 Dec 2015 by Drugs.com

MONDAY, Dec. 21, 2015 – Gay and bisexual men who have abstained from sex for one year will now be allowed to donate blood in the United States. The new policy, announced Monday by the U.S. Food and Drug Administration, reverses a three-decades-old ban on donations from this group of men that traces back to the start of the AIDS epidemic. "The FDA's responsibility is to maintain a high level of blood product safety for people whose lives depend on it," FDA Acting Commissioner Stephen Ostroff said in an agency news release. "We have taken great care to ensure this policy revision is backed by sound science and continues to protect our blood supply." The FDA said it was changing its policy based on data from other countries that show allowing such donations would not increase the risk of HIV-tainted blood entering America's blood supply. FDA officials have estimated that about half of the ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Harvoni, HIV Infection, Valtrex, Acyclovir, Anemia, Tamiflu, Atripla, Ribavirin, Valacyclovir, Pre-Exposure Prophylaxis, Incivek, Blood Transfusion, Zovirax, Truvada, Stribild, Complera, Triumeq, Famciclovir

Seniors More Likely to Wind Up in Hospital After Outpatient Surgery: Study

Posted 25 Aug 2015 by Drugs.com

TUESDAY, Aug. 25, 2015 – Seniors are much more likely than younger people to find themselves in the hospital after outpatient surgery, a new study finds. "These seniors were supposed to stay out of the hospital since the procedures were performed in the ambulatory setting, but they were admitted to the hospital within 30 days," corresponding study author Dr. Gildasio De Oliveira Jr., an assistant professor in the Center for Healthcare Studies at Northwestern University's Feinberg School of Medicine in Chicago, said in a university news release. "Age was the biggest factor associated with readmission and complications. It's not because they are sicker, it's because they are older and have trouble understanding their discharge instructions and medication dosing, which often are not clearly explained," he said. Researchers analyzed data from more than 53,000 Americans who underwent ... Read more

Related support groups: Infections, Surgery, Bleeding Disorder, Influenza, Blood Transfusion, Postoperative Infection

Study Sees No Link Between Testosterone Therapy and Blood Clots

Posted 20 Jul 2015 by Drugs.com

MONDAY, July 20, 2015 – Testosterone therapy doesn't appear to increase the risk of blood clots in veins, a new study contends. The most common forms of this problem – called venous thromboembolism (VTE) – are deep vein thrombosis (a clot in the leg) and pulmonary embolism (a clot in the lungs). VTE is the third most common type of cardiovascular problem, after heart attack and stroke, the researchers said. There is conflicting information about the link between testosterone therapy and the risk of VTE. As a result, many men with low testosterone and their doctors are reluctant to start testosterone therapy, the study investigators said. "In 2014, the [U.S.] Federal Drug Administration required manufacturers to add a warning about potential risks of VTE to the label of all approved testosterone products," study author Jacques Baillargeon, a professor of epidemiology at the University ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Testosterone, AndroGel, Testim, Axiron, Androderm, Depo-Testosterone, Testopel, Fortesta, Testopel Pellets, Testim 5 g/packet, Coagulation Defects and Disorders, Delatestryl, Testosterone Topical, Striant, AndroGel 1.25 g/actuation, Aveed, Depotest, FIRST-Testosterone

Antidepressant, Painkiller Combo May Raise Risk of Brain Bleed

Posted 14 Jul 2015 by Drugs.com

TUESDAY, July 14, 2015 – Taking both an antidepressant and a painkiller such as ibuprofen or naproxen may increase risk of a brain hemorrhage, a new study suggests. Korean researchers found that of more than 4 million people prescribed a first-time antidepressant, those who also used nonsteroidal anti-inflammatory drugs (NSAIDs) had a higher risk of intracranial hemorrhage within the next month. Intracranial hemorrhage refers to bleeding under the skull that can lead to permanent brain damage or death. The findings, published online July 14 in BMJ, add to a week of bad news on NSAIDs, which include over-the-counter pain relievers such as aspirin, ibuprofen (Motrin, Advil) and naproxen (Aleve). Last Thursday, the U.S. Food and Drug Administration strengthened the warning labels on some NSAIDs, emphasizing that the drugs can raise the risk of heart attack and stroke. As far as the new ... Read more

Related support groups: Lexapro, Zoloft, Wellbutrin, Cymbalta, Bleeding Disorder, Effexor, Prozac, Celexa, Citalopram, Paxil, Trazodone, Sertraline, Pristiq, Ibuprofen, Amitriptyline, Bupropion, Viibryd, Naproxen, Fluoxetine, Effexor XR

Anti-Vaccine Trend Has Parents Shunning Newborns' Vitamin Shot

Posted 6 Jul 2015 by Drugs.com

MONDAY, July 6, 2015 – With the recent U.S. measles outbreak, the issue of vaccine refusal has received growing scrutiny. Now doctors are calling attention to a similar problem: Some parents are shunning the vitamin K shot routinely given to newborns to prevent internal bleeding. The consequences of that choice can be severe, pediatric specialists say. Infants can quickly become deficient in vitamin K, which can lead to dangerous bleeding in the intestines or the brain. "If you refuse the shot, you're rolling the dice with your child's health," said Dr. Robert Sidonio Jr., a hematologist and assistant professor of pediatrics at Emory University in Atlanta. Vitamin K is necessary for normal blood clotting. In older children and adults, bacteria in the gut produce much of the vitamin K the body needs. But that's not the case for infants. And breast milk does not supply enough vitamin K ... Read more

Related support groups: Bleeding Disorder, Delivery, Coagulation Defects and Disorders, Vaccination and Prophlaxis, Bleeding Associated with Coagulation Defect

Researchers Report Progress in Making All Blood Types Universally Accepted

Posted 21 May 2015 by Drugs.com

THURSDAY, May 21, 2015 – Scientists are closing in on a way to transform any type of donated blood into type O, the universal blood type that can safely be given to any patient. Researchers have created a special enzyme that can shear off the substances on red blood cells that are responsible for potentially fatal immune reactions if a patient receives the wrong type of blood, according to a new study. The enzyme is not yet effective enough to allow for large-scale processing to convert type A or type B blood into type O, said lead author David Kwan, a postdoctoral fellow of chemistry at the University of British Columbia's Centre for Blood Research in Vancouver, Canada. "We're not there yet. This is really a step towards that," Kwan said. "The big thing is that we've shown that it's feasible to improve these enzymes." Results of the study were published online recently in the Journal ... Read more

Related support groups: Blood Disorders, Bleeding Disorder, Anemia, Blood Transfusion, Exchange Transfusion, Blood Cell Transplantation, Anemia Prior to Surgery

Does Long-Term Acetaminophen Use Raise Health Risks?

Posted 3 Mar 2015 by Drugs.com

MONDAY, March 2, 2015 – Acetaminophen may not be as safe as previously thought, with larger doses and long-term use linked to increased risk of health problems, a new report contends. Best known in the United States under the brand name Tylenol, acetaminophen is the most widely used painkiller in the world, the study authors said in background notes. It is the World Health Organization's front-line treatment for pain, and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen, the researchers said. But a small group of studies has raised questions about acetaminophen's safety if used for a long time and at high doses to treat chronic pain, said lead author Dr. Philip Conaghan, a professor with the Leeds Institute of Rheumatic and Musculoskeletal Medicine in England. Heavy use of acetaminophen is associated with kidney disease and bleeding ... Read more

Related support groups: High Blood Pressure, Percocet, Vicodin, Bleeding Disorder, Norco, Hypertension, Lortab, Tylenol, Ischemic Stroke, Acetaminophen, Paracetamol, Fioricet, Endocet, Excedrin, Darvocet-N 100, NyQuil, Tylenol PM, Acetaminophen/Hydrocodone, Tylenol with Codeine, Percocet 10/325

Tretten Approved for Genetic Clotting Disorder

Posted 23 Dec 2013 by Drugs.com

MONDAY, Dec. 23, 2013 – Tretten (coagulation factor XIII A-Subunit recombinant) has been approved by the U.S. Food and Drug Administration to treat a very rare blood clotting disorder called congenital Factor XIII A-Subunit deficiency. People with the genetic disorder do not make enough Factor XIII, a blood component that promotes clotting. Tretten, a human recombinant produced in yeast cells, makes up for this deficiency, which could otherwise be life threatening, the FDA said Monday in a news release. Tretten was evaluated in a clinical study of 77 people with the disorder. Administered monthly, it was effective in preventing bleeding in 90 percent of recipients. Side effects included headache, extremity pain and pain at the injection site. No study participant developed abnormal clotting, the FDA said. The product was developed and is produced by Novo Nordisk, based in Denmark. More ... Read more

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