I have been on 300mg of Effexor XR for at least 15 years. All of a sudden, these past two weeks have me in a terrible slump of depression and anxiety. I can't eat, sleep, go anywhere and have bad thoughts. I would like to know if anyone out there has tried Rexulti with Effexor XR. As for side effects, I don't care about any of them as long as I don't have bad thoughts or feel depressed or anxious. I would rather be 500lbs, or have cancer, or lose a limb than have no control over my thoughts. Thank you for any info!