Is it possible to overdose on Benadryl?

Bottom line, follow the label for use. I am a Critical Care Paramedic and also work in a major metro Emergency Department. Taking on a does above 300+ mg will cause different effects. People and teens intentionally OD on Benadryl taking 300-800 mg orally to get a "high". Depending on multiple variables (patients weight etc) it causes the person to see things and answer questions they were not asked. I saw this just last week in 2 male patients of 15 years old. The OD causes tachycardia (rapid heart rate), and hypertension (high blood pressure).

Take it as directed by label or MD only or results will vary.

Absolutely! I did so myself, accidentally. Ok so I wanted to sleep, was having psychological issues and downed a whole bottle. It took about an hour and a half but when I started to feel it it hit hard. I remember hallucinating and acting like a drunk person. My parents tell me that in the emergency room I went into seizures. This stuff is not something to play with, I was scared to take it at all for a while after that incident. I also remember the nurse putting the tube up my nose and me fighting the whole time. Then she put the charcoal in and everything came up, instantly. I still remember her face, I hit her, slapped her, kicked and screamed. I saw my dog in the hospital looking for me, I called out for her. This was a scary thing and I NEVER want to do it again.

yes. the dose that has been known to od and death in rats is 500 mg/kg. that would be 20 pills to get 500 mg. I normally use 20-50 pills: that is 500 mg to 1250 mg. if I take to many i start to vomit it out. I have also had seizures. so, since can cause the mentioned symptoms one can od; but i have not known anyone that died from it yet. depending on tolerance you can take more then 36.I hope this helps