I have been taking Norco/hydrocodone 10 325 three Pills allowed a day since May 2016, very recently we moved and a friend that I've known for eight years brought a girl with him claimed he knew her very well turns out he didn't so therefore she 25 of my pain meds. I have 10 of the oxycodone 10 325 from about six months ago not expired and I have taken one in the morning and then one at night and that's it. The reason I don't take three like the hydrocodone 10 325 a day is because I don't have that many and I have to wait another eight days before I get my prescription filled. The point of my question is why is it that the Norco/hydrocodone 10 325 which are yellow I get from H-E-B work way better then the Oxycodone 10 325???
Hydrocodone 10 325 versus oxycodone 10 325 which one is stronger?
Question posted by HayBro on 3 Feb 2017
Last updated on 28 December 2023
10 Answers
mjb1965
6 Nov 2023
I'm trying to find out the difference between pain relief from oxycodone with Tylenol 10-325 and hydrocodone with Tylenol 10-325
Alco89
26 Sep 2023
I use 10 325 Hydrocodone for many years and it helps my back pain, but lately walgreens said they won't have it until next month. I been out for 2 days and a friend gave me oxycocone 5 MG. I asked the pharmacist is it stronger that what I take, he said 1 to 10 it;s about a 7, not as strong as what I'm use too. Still haven't taken one but maybe today I will.
gslick2u
24 Aug 2021
I had been on oxycodone 10/325 since 1982. I fell from a tree and broke my back which has caused back pain ever since. I tried hydrocodone 10/325 but I did not like it the hydrocodone 10/325 worked to slow. Percocet is a combination of oxycodone and acetaminophen. Oxycodone is a semi-synthetic opiate that is made by modifying thebaine, an organic compound in opium with the addition of Tylenol so it acts faster than hydrocodone. Percocet is not recommended for long-term use because acetaminophen has been found to cause serious liver damage. That's why some doctors prescribe hydrocodone 10/325 which Hydrocodone is a semi-synthetic opioid drug, derived from the opiate codeine.
When thebaine is modified for oxycodone one (1) more molecule of oxygen is formed causing the drug to be absorbed faster so its able to acts quicker.
As stated before every person is different. My doctor switched me from Percocet to plain oxycodone 15mg. It works but not like the Percocet 10/325 even though its 15mg. To help the oxycodone 15mg. work faster and better I take 300mg of Tylenol with each tablet.
Shirley Goodman
27 Nov 2020
In my case I say No... I have had 4 back surgeries, and don't want to another one.
LemonEatingRat
3 Oct 2017
Structurally, oxycodone (molecular formula C18H21NO4) and hydrocodone (molecular formula C18H21NO3) are very similar, the difference in their structure comes down to one extra oxygen atom on Oxycodone.
Oxycodone is semi-synthetic and is synthesized from thebaine (an opium alkaloid) and will only relieve pain, not cough. Hydrocodone is also semi-synthetic but derived from codeine. They are the same at pain relief. DUH
bobsy
28 Dec 2023
No, incorrect. If you will look at an Equianalgesic you will see that Oxycodone is 1.5 times stronger than Hydrocodone. By the way all hydrocodone that is IR (immediate release) has acetaminophen in the pill along with the hydrocodone.
Tlbenson
13 Sep 2017
That's what I'm asking what is stronger a Percocet 10/325 Than a hydrocodone 10/325
mjb1965
6 Nov 2023
I am trying to find out the same thing and I get answers that they are the same thing
to they are different like the hydro is more powerful or the oxycodone is stronger. I am giving it up maybe the drug company can tell us !!! lol
Gabbie5177
27 July 2017
Oxycodone have different brands I take the endocet 10/325mg they r yellow and it works. Ask your doctor to write you the endocets 10/325 see how it works for you.
Potus45sucks
27 Feb 2017
According to all manufacturers of hydrocodone 10/325 and oxycodone 10/325 the oxycodone 10/325 is almost 2x stronger than the hydrocodone. I have taken both and the oxycodone is stronger. Perhaps you have convinced yourself that the oxycodone is not as strong. Mind over matter. Take the oxycodone and tell your brain to shut the f**k up.
HayBro
1 March 2017
LOL... Thanks for your input!!!
I appreciate it, I love the comment " Take the Oxycodone and tell your brain to shut the f**k up!!! That's awesome!!!
HayBro
1 March 2017
LOL... Thanks for your input!!!
I appreciate it, I love the comment " Take the Oxycodone and tell your brain to shut the f**k up!!! That's awesome!!!
cindystuart
7 June 2017
Oxy definitely stronger than hydro. I have both 10/325. Our bodies react differently. Oxycodone still gives me a buzz and makes my eyes blurry and gives me a headache. I have No side effects from hydrocodone so I prefer that for pain. No buzz, no tiredness, moderate pain relief. Both Will cause physical dependency which sucks. Withdrawal is worse than the pain you're taking it for so beware. Must gradually taper. Cut pill several parts, take 1 piece at reg intervals for week, eliminate 1 piece, repeat. Will take time but u wont suffer.
chuck1957
4 Feb 2017
Haybro here is the drug id on the Oxycodone/325 and it is the right thing.10/325 M5231/3 Previous Image Next Image
Drug: Acetaminophen and Oxycodone Hydrochloride
Strength: 325 mg / 10 mg
Pill Imprint: 10/325 M523
Color: White
Shape: Capsule-shape
View Images & Details Print
Everyone reacts differently to different medications they are still the right strength let your doctor know that the Oxycodone is not working for you at all. Normally Oxycodone would be stronger for most people but we are not all the same and they can act differently on each of us. but you do have the right medications so call your doctor Monday if your still having problems with pain and let them know the one is not working at all. good luck
HayBro
7 Feb 2017
Thank you so much!!!
chuck1957
28 July 2017
Potus45sucks: is correct when you compare these 2 medications, But when we are on one for a longer period of time, it's strange but it can feel like the medication that is just a bit different in structure can feel like it is working better.This is very common on many medications so the doctor will switch for a while then put you back on the real stronger one. and then you start getting the relief you did before. hope you're doing ok by now. Chuck1957 Thanks a lot, Potus45; Just need to be honest on how they work and they don't really have any Idea. CHUCK.
botta71
3 Feb 2017
Oxycodone is stronger than hydrocodone.
HayBro
4 Feb 2017
Thank you for responding... but, I was more less asking, why the Oxycodone 10/325 wasn't working at all for my pain...
The Hydrocodone (yellow) 10/325 works way better. (It at least takes the edge off).
The Oxycodone 10/325 which are white, didn't even take the edge off at all.
The Oxycodone are long white and has 10/325 on one side and M523 on the other side. If oxy's are stronger than the hydro's
why didn't they at least take the edge off?
Do you have any suggestions, or reasoning at all?
Do you think that maybe my body is just used to Hydrocodone?
The bottle is 6 months old but not expired, it says discard after September 2017...
By chance, do you think it is possible that they lost some of their potency?
tsimm97
1 Oct 2018
People respond differently to different medications. We're not machines.
Related topics
norco, pain, hydrocodone, oxycodone, chronic pain, pill
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