I have been diagnosed with insulin resistance Nov 2011. Taking METFORMIN, HCL ER 2000mg (since 11/4/11 worked my way up to full dose). Been on full dose for 2.5 weeks now. No weight loss. I am keeping total daily carbs under 45grams per day. Total calories < 1400. PROTEIN = 60-80GRAMS PER DAY. Diet controlled w/dietician every 6 weeks. I work out 5x per week, 45 mins each time = 50/50 cardio/strength training. Drink 8 glasses of water per day. I am very frustrated. How long does full dose of MET 2000mg take to lose any weight? My endo says he feels I can lose 10 lbs by the follow up appt 2/3/12. I haven't lose one ounce yet. PLEASE HELP. DEE