I take 150mg Effexor XR at 6pm everyday have done so for many years. I was prescribed Tramadol 50mg 1-2, 2 times a day for a workplace injury.
I have read that the two can Interact and cause the body to produce to much serotonin leading to mild or severe serotonin syndrome. On the contrary I also have read that people do take the two together probably not at the same time I'm guessing but have had no problems.
I understand that It is a personal thing and that everyone will react differently. I have just taken 100mg just before at 1.00pm and will be taking my usual Effexor XR at 6-7pm after dinner.
When I spoke to my doctor about my Effexor being taken at night (different doctor prescribed it 6 years ago) and not in the morning he told me that it is mostly taken in the mornings and I will be changing that within a few days after I establish my relationship with Tramadols effects.
Will report back on how it goes and any information and or experiences are welcome.
Thanks
*Louig*
I also was wondering if you had to change around the times at which you took the two meds in order to avoid interactions? Thanks!
I tell you what I have found MOST Dr's really don't know what drug does what with each drug. If you really want to know find yourself a pharmacist that is also a compounding pharmacist that's the most important part because that means they can mix anything and make any combo of drug needed. They have an intimate knowledge of the chemical make up of these drugs and can tell you exactly what will adversely affect you with your combination of RX. However you need to keep your Dr in the loop !!!
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QU
Quando62
14 Nov 2014
Interesting combination since Tramadol and Effexor are SO similar on the same exact receptors.
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BA
balbanese
14 Nov 2014
If they're clashing it won't matter how you space them out, they still wind up in your system together
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DE
Delila
14 Nov 2014
Hi there is a risk of serotonin syndrome as both medication increase your serotonin levels. As Kaismama has said, you can't avoid the interaction if you are taking both medications daily. I also used to take 2 x SSRI medications alongside Tramadol with no problems, but everybody is different. What has your doctor said about the potential interaction risk? Has he considered an alternative analgesic?
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KA
kaismama
14 Nov 2014
You can't avoid drug interactions by taking them at different times. The interaction is in the blood not the stomach and effexor is always in your blood I took 150 of effexor and 400 of Tramadol every day for more than. 10 yrs without a problem.
