What can I buy over the counter to replace Desonide lotion 0.05?

What are you using the Desonide lotion for? It can be used for psoriasis, eczema, or dermatitis in adults and children. Are you trying to keep moisture in or out?

If you're using it for psoriasis, you'd want to find a lotion that doesn't contain any alcohol.

If you're using it for eczema or dermatitis, you'd probably want to use something with an anti-histamine.

If you're using it for diaper rash, you could try something else on the market like Butt Aid, Desitin, or A&D ointment.