Vanguard Plus 5 L4

Company: Zoetis

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine

Modified Live Virus

Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin

For use in dogs only

For vaccination of healthy dogs 6 weeks of age or older as an aid in preventing disease caused by CD virus, CAV-1, CAV-2, CPI virus, CPV and CPV-2c, Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona. Vanguard Plus 5 L4 contains attenuated strains of CD virus, CAV-2, CPI virus, CPV, and inactivated whole cultures of the four Leptospira serovars mentioned above. The high-titer, low-passage CPV virus in Vanguard Plus 5 L4 is highly immunogenic and capable of stimulating active immunity in the presence of maternal antibodies. This product does not contain CPV type 2c. Cross protection against CPV type 2c was demonstrated in vaccinated puppies challenged 5 weeks following second vaccination.

Vaccination and revaccination according to label directions have been demonstrated (under field conditions) to result in serum antibody titers that persist for 12-48 months against CAV- 1 (SN ≥ 1:16), CAV-2 (SN ≥ 1:16), CPI virus (SN ≥ 1:16), and CPV (hemagglutination inhibition [HAI] titer ≥ 1:80).

Directions For Use

Aseptically rehydrate the freeze-dried vaccine (Vanguard Plus 5 L4) with the sterile gel provided, shake well, and administer 1 mL subcutaneously or intramuscularly. Healthy dogs should receive 2 doses administered 3 weeks apart. To avoid the potential for maternal antibody interference, dogs vaccinated at less than 9 weeks of age should receive 3 doses, each administered 3 weeks apart. Annual revaccination with a single dose is recommended. Duration of immunity has not been established.

Precautions

Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine. Burn containers and all unused contents. Contains gentamicin as preservative. Vaccination of pregnant bitches should be avoided. In case of anaphylaxis, administer epinephrine or equivalent.

Technical inquiries should be directed to Zoetis Inc. Veterinary Services, (888) 963-8471 (USA), (800) 461-0917 (Canada).

This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.

U.S. Veterinary License No. 190

Zoetis Inc., Kalamazoo, MI 49007

CPN: 36902276