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Oxytocin Injection

This page contains information on Oxytocin Injection for veterinary use.
The information provided typically includes the following:
  • Oxytocin Injection Indications
  • Warnings and cautions for Oxytocin Injection
  • Direction and dosage information for Oxytocin Injection

Oxytocin Injection

This treatment applies to the following species:
Manufacturer: Vedco

Sterile Solution

20 U.S.P. Units per mL

NADA 109-305, Approved by FDA

FOR USE IN ANIMALS ONLY

RESTRICTED DRUG (CALIFORNIA)

USE ONLY AS DIRECTED

OXYTOCIN is a nonapeptide hormone prepared by synthesis.

It is a sterile aqueous solution containing the equivalent of 20 U.S.P. units Oxytocin, less than 0.4 units of pressor activity per mL. The preservative is 0.5% Chlorobutanol.

Each mL CONTAINS:

Oxytocin (synthetic)

20 USP units

Sodium chloride

0.9% w/v

Clorobutanol

0.5% w/v

Water for Injection

q.s

ph adjusted with Acetic Acid and/or Sodium Hydroxide.

Oxytocin acts directly on the smooth musculature of the uterus in all species to produce rhythmic contractions although it has been demonstrated in some species that the uterine cervix will not respond to oxytocin. The degree of uterine activity elicited by oxytocin depends to a great extent on the stage of the reproductive cycle. Most authorities agree that the level of estrogen and progesterone in the various phases of pregnancy is the main controlling factor of the activity that oxytocin has on the uterus. During the early phases of normal pregnancy, the uterus is relatively insensitive to oxytocin. In the late phases, the sensitivity is increased.

OXYTOCIN has the integral relationship with the letdown of milk. Some authorities refer to this as the galactogogic effect. The mechanism by which milk is discharged from the mammary glands is not definitely known, but Oxytocin is presumed to act on certain smooth muscle elements in the gland. It has been clearly demonstrated, however, that Oxytocin will promote a prompt milk-ejecting effect.

Oxytocin Injection Indications

Due to Oxytocin’s specific action on the uterine musculature, it is recommended as an aid in the management of the following conditions:

1. To precipitate labor

2. To accelerate normal parturition

3. Postpartum evacuation of uterine debris

4. Postoperative contraction of the uterus following Cesarean section and control of uterine hemorrhage.

Because of Oxytocin’s milk ejecting effect, it will contract smooth muscle cells of the mammary gland for milk letdown if the udder is in proper physiological state.

Dosage and Administration

For obstetrical use. Oxytocin may be injected intravenously, intramuscularly or subcutaneously, under aseptic conditions as indicated. The following dosages are recommended and may be repeated as conditions require:

CATS

0.25 to 0.5 mL

5 to 10 U.S.P. units

DOGS

0.25 to 1.5 mL

5 to 30 U.S.P. units

EWES, SOWS

1.5 to 2.5 mL

30 to 50 U.S.P. units

COWS, HORSES

5.0 mL

100 U.S.P. units

For augmenting the letdown of milk, intravenous administration is desirable. The following dosage is recommended and may be repeated as conditions require:

COWS

0.5 to 1.0 mL

10 to 20 U.S.P. units

SOWS

0.25 to 1.0 mL

5 to 20 U.S.P. units

Use product within 60 days of the first puncture. Do not puncture the stopper more than 133 times.

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications

Do not use in dystocia due to abnormal presentation of fetus until correction is accomplished.

Precautions

Oxytocin is a potent preparation. Therefore, it should be administered with due caution. For prepartum usage, full dilation of the cervix should be accomplished either naturally or by administration of Estrogen prior to Oxytocin therapy.

SUPPLIED: Oxytocin is available in 100 mL multiple dose vials.

Oxytocin Injection Caution

KEEP THIS AND ALL OTHER MEDICATIONS OUT OF THE REACH OF CHILDREN.

Keep refrigerated 36-46°F (5°±3°C). Do not freeze.

Distributed By VEDCO, INC., St. Joseph, MO 64507

Iss. 01-15

NET CONTENTS:

NDC

 

 

100 mL

50989-140-12

VINV-OXYT-100M

Iss. 01-15

NAC No.: 1094320.0

VEDCO, INC.
5503 CORPORATE DR., ST. JOSEPH, MO, 64507
Telephone:   816-238-8840
Toll-Free:   888-708-3326 (888-70VEDCO)
Fax:   816-238-1837
Website:   www.vedco.com
Every effort has been made to ensure the accuracy of the Oxytocin Injection information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2015 North American Compendiums. Updated: 2015-07-09

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