Skip to Content


This page contains information on Guardian for veterinary use.
The information provided typically includes the following:
  • Guardian Indications
  • Warnings and cautions for Guardian
  • Direction and dosage information for Guardian


This treatment applies to the following species:
Manufacturer: Intervet/Merck Animal Health

Bovine Rotavirus-Coronavirus Vaccine, Killed Virus, Clostridium Perfringens Types C & D-Escherichia Coli Bacterin-Toxoid

Guardian® vaccine is a multiple antigen product which includes a cell-free extract of K99 pilus type of Escherichia coli, a unique combination of two inactivated coronaviruses, two G-types of inactivated rotaviruses and a bacterin-toxoid from Clostridium perfringens Types C and D. It is recommended for use in healthy pregnant heifers and cows as an aid in the prevention of neonatal calf diarrhea caused by enterotoxigenic E. coli pilus type K99, bovine Group A Serotype G6 rotaviruses, enterotoxemia caused by C. perfringens Types C and D, and as an aid in the control of neonatal calf diarrhea caused by bovine coronaviruses.

DOSAGE: Using aseptic technique, inject healthy pregnant cattle with 2 mL subcutaneously 3 months prior to calving. Repeat in 3 - 6 weeks following initial vaccination. For subsequent calvings, revaccinate with a single 2 mL dose 5 - 7 weeks before calving. For E. coli, protection was shown when the first dose was given as early as 6 months prior to calving.

Guardian Caution

For veterinary use only. Store at 2° to 7°C (35° to 45°F). Do not freeze. Shake well before use. Use entire contents when first opened. Do not vaccinate within 60 days before slaughter. Transient local reaction may occur at the injection site. If allergic response occurs, administer epinephrine.

PRESERVATIVES: Gentamicin and thimerosal.

Intervet Inc., Omaha, NE 68103 USA

U.S. Veterinary License No. 165A

1 800 211-3573 (USA)

© 2003, 2010, Intervet Inc.

All rights reserved.





10 Doses

20 mL



50 Doses

100 mL



NAC No.: 10472415

Intervet Inc.

Customer Service:   800-521-5767
Order Desk:   800-648-2118
Technical Service (Companion Animal):   800-224-5318
Technical Service (Livestock):   800-211-3573
Fax:   973-937-5557
Every effort has been made to ensure the accuracy of the Guardian information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2015 North American Compendiums. Updated: 2015-09-25