Enterovax

Tenosynovitis Vaccine

Modified Live Virus

DIRECTIONS FOR USE, READ CAREFULLY

ENTEROVAX Vaccine is a live vaccine containing an avian reovirus (tenosynovitus biotype) in a freeze-dried preparation sealed under vacuum. It is recommended for use in healthy chickens to aid in the prevention of reovirus induced tenosynovitis (viral arthritis) by spray or drinking water administration.

WHEN TO VACCINATE

SPRAY METHOD: 1 day of age.

WATER: 1 week of age or older.

YOUR VACCINATION PROGRAM

The development of a durable, strong protection to this disease depends upon the use of an effective vaccination program as well as many other circumstances such as administration techniques, environment and flock health at the time of vaccination. Also, the immune response to one vaccination under field conditions is seldom complete for all animals within a given flock. Even when vaccination is successful, the protection stimulated in individual animals against different diseases may not be life long. Therefore, a program of periodic revaccination may be necessary.

PREPARATION OF THE VACCINE

FOR SPRAY:

1. Do not open and mix the vaccine until ready for use.

2. Mix only one vial at a time and use entire contents within 2 hours.

3. Remove the tear-off aluminum seal and stopper from the vial containing the dried vaccine.

4. Remove the tear-off aluminum seal and stopper from the bottle containing the diluent. Insert long end of adapter into diluent bottle.

5. Hold the diluent bottle firmly in an upright position and insert the vaccine vial on the adapter of the diluent bottle. The neck of the vaccine vial should snap into position and should be seated securely on the adapter on the diluent bottle.

6. Invert the two containers so that the vaccine vial is on the bottom and allow the diluent to flow into the vaccine vial. If the diluent does not flow freely, squeeze the bottle gently and the diluent will flow into the vaccine vial. The vaccine vial should be completely filled with diluent to prevent excess foaming.

7. Hold the joined containers by the ends; shake vigorously until the vaccine plug is completely dissolved.

8. Return the joined containers to their original position (diluent bottle on the bottom). Allow the vaccine to flow into the diluent bottle. If the vaccine does not flow into the diluent bottle, tap or squeeze the diluent bottle gently and release to draw the vaccine into the diluent bottle. Be sure all the product is removed from the vaccine vial.

9. Remove the vaccine vial and adapter from the neck of the diluent bottle.

10. The vaccine is now ready for use.

FOR DRINKING WATER:

1. Do not open and mix the vaccine until ready for use.

2. Mix only one vial at a time and use entire contents within 1 hour.

3. Remove the tear-off aluminum seal from the vaccine vial without disturbing the rubber stopper.

4. Use cool, clean, non-chlorinated tap water to which powdered milk has been added as directed under HOW TO VACCINATE.

5. Remove the rubber stopper from the vaccine vial and rehydrate the vaccine by filling the vial about half-full with tap water (milk added).

6. Reseat the stopper and shake to thoroughly dissolve the vaccine.

7. The vaccine is now ready for use.

HOW TO VACCINATE

BY SPRAY: Use this method for day of age vaccination. Proper coarse spray application of this vaccine is best accomplished through use of a clean spray cabinet, such as the ASL SPRAMARK II, adjusted to deliver approximately 7 mL per 100 chicks. Rehydrate the vaccine according to the above instructions “PREPARATION OF THE VACCINE FOR SPRAY.”

Further dilute each 1000 doses of vaccine to 70 mL, each 2500 doses of vaccine to 175 mL, or each 5000 doses to 350 mL using distilled water. Following the spray cabinet directions, adjust the cabinet so that 100 chicks are sprayed with 7 mL of the diluted vaccine over a two second period.

BY DRINKING WATER: Do not mix the vaccine into the drinking water until ready for use. Drinking water for vaccination should be mixed with powdered milk to prevent inactivation from chlorine or other water additives and also to stabilize the vaccine virus. The powdered milk should be added to the water at the rate of 3 grams per 11 liters (one heaped teaspoon per 3 U.S. gallons or 2.5 Imp. gallons); or 90 grams per 300 liters (one heaped cupful per 80 U.S. gallons or 66 Imp. gallons).

Use only clean waterers and equipment free of disinfectants or sanitizers. All water must be withheld from the birds for at least 2 hours prior to vaccination to assure that all birds drink. Mix the rehydrated vaccine in the quantity of drinking water (milk added) which will be consumed by thirsty chickens in approximately 1 hour.

Add the rehydrated vaccine to water as follows:

Distribute diluted vaccine so that all birds are able to drink within one hour. The diluted vaccine should be the sole source of drinking water until completely consumed. Avoid placing water in direct sunlight.

CAUTION

1. For veterinary use only.

2. Vaccinate only healthy birds.

3. Do not spill or spatter the vaccine. Burn empty bottles, caps and all unused vaccine and accessories. Use entire contents of vial when first opened.

4. Wash hands thoroughly after using the vaccine.

5. Store at 2° to 7°C (35° to 45°F). Do not freeze.

6. Do not vaccinate within 21 days of slaughter.

7. Do not administer this product by injection. Studies have demonstrated that injection will produce significant mortality in day of age birds.

8. Do not administer using an automatic eyedrop vaccinator (eg. Biojector-Plus) to day of age birds.

9. Do not administer this product to breeders 18 weeks of age or older. Studies have demonstrated that the vaccine virus will be shed in the eggs.

PRESERVATIVE

This vaccine contains gentamicin.

RECORDS

Keep a record of vaccine type, quantity, serial number, expiration date, and place of purchase; the date and time of vaccination; the number, age, breed, and location of the birds; names of operators performing the vaccination and any observed reactions.

U.s. Federal Regulations Prohibit Repackaging Or Sale Of The Contents Of Carton In Fractional Units. Do Not Accept If Seal Is Broken.

U.S. Veterinary License No. 165A

Schering-Plough Animal Health Corp., Omaha, Nebraska 68103, USA

1 800 219-9286 (USA)

1 888 306-0069 (Canada)

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Schering-Plough Animal Health Corp.

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Made in USA

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P16702-14

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