Enterovax

Tenosynovitis Vaccine

Modified Live Virus

DIRECTIONS FOR USE, READ CAREFULLY

Description

ENTEROVAX Vaccine is a live vaccine containing an avian reovirus (tenosynovitis biotype) in a freeze-dried preparation sealed under vacuum.

Enterovax Indications For Use

This product has been shown to be effective for the vaccination of healthy chickens 1 day of age or 1 week of age or older against reovirus induced tenosynovitis (viral arthritis). Duration of immunity has not been established. For more information regarding efficacy and safety data, see productdata.aphis.usda.gov.

Vaccination Program

The development of a durable, strong protection to this disease depends upon the use of an effective vaccination program as well as many circumstances such as administration techniques, environment and flock health at the time of vaccination. Also, the immune response to one vaccination under field conditions is seldom complete for all animals within a given flock. Even when vaccination is successful, the protection stimulated in individual animals against different diseases may not be life long. Therefore, a program of periodic revaccination may be necessary.

Preparation Of Vaccine

FOR DRINKING WATER OR COARSE SPRAY USE

DO NOT OPEN AND MIX THE VACCINE UNTIL READY TO BEGIN VACCINATION. USE VACCINE IMMEDIATELY AFTER MIXING.

1. Remove the tear-off seal and stopper from the vial containing the lyophilized vaccine.

2. Carefully pour clean, cool, non-chlorinated water into the vaccine vial until the vial is approximately two-thirds full.

3. Insert the rubber stopper and shake vigorously until all material is dissolved.

4. The vaccine is now ready to be applied as per label in accordance with the directions below. For best results, be sure to follow directions carefully!

Drinking Water Administration

FOR CHICKENS ONE WEEK OF AGE OR OLDER

1. Do not use any disinfectants in the drinking water for 48 hours before vaccinating and 24 hours after vaccination.

2. Withhold water from the chickens until they are thirsty.

3. Calculate the water volume needed so the vaccine will be consumed in approximately 2 hours.

4. Optional: as an aid in preserving the virus, add a vaccine stabilizer to the stock solution or to the tank containing clean, cool, non-chlorinated water. Agitate thoroughly. Follow the manufacturer’s rate of administration and wait time.

5. Add rehydrated vaccine from vial to the water and mix thoroughly.

6. Turn on tank valve or automatic dosing system.

7. Provide as sole source of drinking water until all vaccine-water solution has been consumed.

Coarse Spray Administration

FOR CHICKENS ONE DAY OF AGE

Calculate the water volume needed. For example, a machine which dispenses 21 ml to a box of 100 chickens - total volume for 1,000 doses is 210 ml and/or 2,000 doses is 420 ml, 5,000 doses is 1,050 ml of non-chlorinated water. For coarse spray in chicken houses, follow manufacturer’s direction for the particular spray machine. Add rehydrated vaccine and mix thoroughly.

Enterovax Caution

1. VACCINATE ONLY HEALTHY CHICKENS

2. All chickens should be vaccinated at the same time.

3. Do not administer this product by injection. Studies have demonstrated that injection will produce significant mortality in day of age chickens.

4. Do not administer this product to breeders 18 weeks of age or older. Studies have demonstrated that the vaccine virus will be shed in the eggs.

5. Use entire contents when first opened.

6. Do not vaccinate within 21 days of slaughter.

7. Store at 2° to 8° C (35° to 46° F). Do not freeze.

8. Inactivate unused contents before disposal.

9. Do not mix with other products, except as specified on the label.

10. In case of human exposure, contact a physician.

11. Contains gentamicin as a preservative.

12. FOR ANIMAL USE ONLY.

Notice

This vaccine has undergone rigid potency, safety and purity tests, and meets Merck Animal Health, U.S. and local regulatory requirements. It is designed to stimulate effective immunity when used as directed, but the user must be advised that the response to the product depends upon many factors, including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of the individual chickens and the degree of field exposure. Therefore, directions should be followed carefully.

Records

Keep a record of vaccine type, quantity, serial number, expiration date, and place of purchase; the date and time of vaccination; the number, age, breed, and location of the chickens; names of operators performing the vaccination and any observed reactions.

FEDERAL REGULATIONS PROHIBIT THE REPACKAGING OR SALE OF THE CONTENTS OF THIS CARTON IN FRACTIONAL UNITS. DO NOT ACCEPT IF SEAL IS BROKEN.

Intervet Inc., Omaha, NE 68103 USA

VLN 165A/PCN 1951.02

1 800 211-3573 (USA)

1 866 683-7838 (CAN)

388039 R4

CPN: 1047058.6