E-Se Injectable (Canada)

This page contains information on E-Se Injectable for veterinary use.
The information provided typically includes the following:
  • E-Se Injectable Indications
  • Warnings and cautions for E-Se Injectable
  • Direction and dosage information for E-Se Injectable

E-Se Injectable

This treatment applies to the following species:
Manufacturer: Merck Animal Health

DIN 00518662

VETERINARY USE ONLY

Description

E-SE is an emulsion of selenium-tocopherol for the prevention and treatment of myositis (Selenium-Tocopherol Deficiency) syndrome in horses. Each mL contains: Active ingredients: Selenium (as sodium selenite) 2.5 mg, Vitamin E (as d-alpha tocopheryl acetate) 68 IU; Preservative: benzyl alcohol 0.02 mL (2% v/v); Inactive ingredients: polyoxyethylated vegetable oil 250 mg, water for injection q.s. Sodium hydroxide or hydrochloric acid may be added to adjust pH.

Pharmacology

It has been demonstrated that selenium and tocopherol exert physiological effects and that these effects are intertwined with sulfur metabolism. Additionally, tocopherol appears to have a significant role in the oxidation process, thus suggesting an interrelationship between selenium and tocopherol in overcoming sulfur-induced depletion and restoring normal metabolism. Although oral ingestion of adequate amounts of selenium and tocopherol would seemingly restore normal metabolism, it is apparent that the presence of sulfur and, perhaps, other factors interfere with the proper utilization of selenium and tocopherol during the digestive process. When selenium and tocopherol are injected, they bypass the digestive process and exert their full metabolic effects promptly on cell metabolism.

E-Se Injectable Indications

Horses: E-SE is recommended for the control of the following clinical signs when associated with myositis (Selenium-Tocopherol Deficiency) syndrome: rapid respiration, profuse sweating, muscle spasms and stiffness, elevated SGOT.

Warning

This drug is not to be administered to horses that are to be slaughtered for use in food.

Adverse Reactions

Selenium is toxic if administered in excess. A fixed dose schedule is therefore important (read package insert for each selenium-tocopherol product carefully before using). Emulsions injected intramuscularly into the horse may produce transitory local muscle soreness and can be prevented to some degree by injecting deeply (5 to 6 cm - 2 to 2 1/2 inches), in divided doses, in two or more sites. Do not continue therapy in horses demonstrating such sensitivity.

Anaphylactoid reactions, some of which have been fatal, have been reported in horses administered with E-SE injectable. Signs include excitement, sweating, trembling, ataxia, respiratory distress, and cardiac dysfunction. Discontinue injection immediately on early signs of anaphylactoid reaction.

E-Se Injectable Cautions

Selenium-Tocopherol Deficiency (STD) syndrome produces a variety and complexity of symptoms often interfering with a proper diagnosis. Even in selenium deficient areas there are other disease conditions which produce similar clinical signs. It is imperative that all these conditions be carefully considered prior to treatment of STD syndrome. Serum selenium levels, elevated SGOT and creatinine levels may serve as aids in arriving at a diagnosis of STD, when associated with other indices.

Important: Use only the selenium-tocopherol product recommended for each species. Each formulation is designed for the species indicated to produce maximum efficacy and safety.

E-Se Injectable Dosage And Administration

Deep intramuscular injections, in divided doses, in two or more sites in the gluteal or cervical muscles. Dosage: 1 mL per 45 kg of body weight. May be repeated at 5-10 day intervals.

How Supplied

100 mL sterile, multiple dose, glass vials. Product Code: 280100

Storage

Store between 2°C and 25°C. Protect from freezing.

Intervet Canada Corp., Kirkland (Quebec), H9H 4M7

1-888-306-0069

® Registered trademark of Schering Corporation, used under license by Intervet Canada Corp.

09-0060INS

CND 3485 1 V

NAC No.: 12080256

MERCK ANIMAL HEALTH
Intervet Canada Corp.

16750 ROUTE TRANSCANADIENNE, KIRKLAND, QC, H9H 4M7
Order Desk:   514-428-7013
Toll-Free:   866-683-7838
Fax:   Toll-free 888-498-4444; local 514-428-7014
Website:   www.merck-animal-health.ca
Every effort has been made to ensure the accuracy of the E-Se Injectable information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-05-28

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