Denagard Medicated Premix (Canada)

Manufacturer: Novartis

(tiamulin)

DIN 00860735

Veterinary Use Only

Active Ingredient

Tiamulin Base: 17.8 g/kg (equivalent to 22 g tiamulin hydrogen fumarate/kg)

For use in swine for the treatment and for the prevention of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin.

Mixing Directions

Thoroughly mix Denagard Premix into complete nonmedicated swine feed for the treatment or for the prevention of swine dysentery at the rates per metric tonne (1,000 kg) of feed as shown in the table below.

Denagard Medicated Premix Indications	Tiamulin Base Use Level	Amount Of Denagard Premix Per Tonne Of Feed
Treatment of Swine Dysentery	178.1 g/tonne	10.0 kg/tonne
Prevention of Swine Dysentery	31.2 g/tonne	1.75 kg/tonne

Feeding Instructions

For treatment of swine dysentery, feed at 178.1 g/tonne for 14 days.

For prevention of swine dysentery, feed continuously at 31.2 g/tonne as the sole ration to swine on premises with a history of swine dysentery but where signs of the disease have not yet occurred. Feed continuously at 31.2 g/tonne to prevent reinfection following use of tiamulin at 178.1 g/tonne for 14 days or following use of tiamulin medicated water for treatment of swine dysentery associated with Brachyspira hyodysenteriae.

Warning

1. Direct contact with skin or mucous membranes may cause irritation.

2. If contact occurs, wash with soap and water.

3. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug at 178.1 g/tonne for therapy for swine dysentery or at least 2 days after use at 31.2 g/tonne for prevention of swine dysentery.

Denagard Medicated Premix Caution

1. Do not use in feeds containing pellet binding agents.

2. Do not feed to animals other than swine.

3. Do not feed undiluted.

4. Swine being medicated with Denagard (tiamulin) should not have access to or be treated with tiamulin incompatible polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin).

5. Use as the only source of tiamulin.

6. Discontinue use if signs of toxicity occur.

7. Do not administer to sows and gilts during four (4) weeks after service.

Adverse Reactions (associated With The Use Of 178.1 G/tonne Level For Treatment Of Swine Dysentery)

i Overdoses Of Denagard Have Sometimes Produced Transitory Salivation, Vomiting And An Apparent Calming Effect On The Pig.

ii In Rare Cases, Redness Of The Skin, Primarily Over The Ham And Underline, Has Been Observed During Medication.

iii If Signs Of Toxicity Or Redness Of The Skin Occurs, Promptly Discontinue Use Of The Therapeutic Level Of Medicated Feed.

note

During treatment swine should be housed under conditions of adequate space and sanitation.

Storage

Store at less than 25°C in a dry place.

Novartis Animal Health Canada Inc., 2000 Argentia Road, Plaza 3, Suite 400, Mississauga, ON L5N 1V9

^® Registered trademark of Novartis AG - Novartis Animal Health Canada Inc., authorized user

Net Weight:
15 kg	NAH/DEN-MP/CAN/BL/1

Nac No.

12310851