Denagard Medicated Premix (Canada)This page contains information on Denagard Medicated Premix for veterinary use.
The information provided typically includes the following:
- Denagard Medicated Premix Indications
- Warnings and cautions for Denagard Medicated Premix
- Direction and dosage information for Denagard Medicated Premix
Denagard Medicated PremixThis treatment applies to the following species:
(tiamulin hydrogen fumarate)
Veterinary Use Only
For Use in Swine Feed Only
Tiamulin Base: 17.8 g/kg (equivalent to 22 g tiamulin hydrogen fumarate/kg)
Denagard Premix contains 14-desoxy-14-[(2-diethylaminoethyl) mercaptoacetoxy] mutilin hydrogen fumarate, a semi-synthetic derivative of the antibiotic, pleuromulin. Each kg contains 17.8 g of tiamulin base equivalent to 22 g of tiamulin hydrogen fumarate.
Therapeutic Classification: Antibiotic.
Denagard Medicated Premix Indications
For use in swine for the treatment and for the prevention of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin.
Dosage and Administration
Mixing Directions: Thoroughly mix Denagard Premix into complete nonmedicated swine feed for the treatment or for the prevention of swine dysentery at the rates per metric tonne (1,000 kg) of feed as shown in the table below.
Denagard Medicated Premix Indications
Tiamulin Base Use Level
Amount of Denagard Premix per tonne of Feed
Treatment of Swine Dysentery
178.1 g/tonne (1,000 kg)
10.0 kg/tonne (1,000 kg)
Prevention of Swine Dysentery
31.2 g/tonne (1,000 kg)
1.75 kg/tonne (1,000 kg)
Feeding Directions: For treatment of swine dysentery, feed at 178.1 g/tonne for 14 days.
For prevention of swine dysentery, feed continuously at 31.2 g/tonne as the sole ration to swine on premises with a history of swine dysentery but where signs of the disease have not yet occurred. Feed continuously at 31.2 g/tonne to prevent reinfection following use of tiamulin at 178.1 g/tonne for 14 days or following use of tiamulin medicated water for treatment of swine dysentery associated with Brachyspira hyodysenteriae susceptible to tiamulin.
Note: Use as the only source of tiamulin. During treatment swine should be housed under conditions of adequate space and sanitation.
1. Do not use in feeds containing pellet binding agents.
2. Do not feed to animals other than swine.
3. Do not feed undiluted.
4. Swine being medicated with Denagard Premix should not have access to or be treated with tiamulin incompatible polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin).
Cautions: For use in swine feed only. This drug should not be administered to sows and gilts 4 weeks after service.
Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug at 178.1 g/tonne for therapy for swine dysentery.
Treated animals must not be slaughtered for use in food for at least 2 days after the latest treatment with this drug at 31.2 g/tonne for prevention of swine dysentery.
Direct contact with the skin or mucous membranes may cause irritation. If contact occurs, wash with soap and water. KEEP OUT OF REACH OF CHILDREN.
1. Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. In very rare cases, death has been reported.
2. In rare cases, redness of the skin, primarily over the ham and underline, has been observed during medication.
3. If signs of toxicity or redness of the skin occurs, promptly discontinue use of the therapeutic level of medicated feed.
StorageStore at less than 25°C in a dry place.
Presentation: Denagard Premix is supplied in a 15kg bag containing 17.8 g of tiamulin per kg (equivalent to 22 g of tiamulin hydrogen fumarate/kg).
Date: June 2012
Manufactured and Distributed by: Novartis Animal Health Canada Inc., 2000 Argentia Road, Suite 400, Mississauga, ON L5N 1V9
® Registered trademark of Novartis AG; Novartis Animal Health Canada Inc., authorized user
NAC No.: 1231085.2
Distributed by ELANCO, Division Eli Lilly Canada Inc. & ELANCO CANADA LIMITED (successor to Novartis Animal Health Canada Inc.)
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|Every effort has been made to ensure the accuracy of the Denagard Medicated Premix information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.|
Copyright © 2015 North American Compendiums. Updated: 2015-11-23