Cydectin (Pour-On for Beef and Dairy Cattle) (Canada)

Moxidectin

(Pour-On for Beef and Dairy Cattle)

DIN 02228386

Veterinary Use Only

(Each mL contains 5 mg of moxidectin)

For the treatment of infections and infestations due to internal and external parasites in cattle, including lactating dairy cows.

External Use Only

Introduction

CYDECTIN Pour-On contains moxidectin, a second generation endectocide of the milbemycin class of compounds. It is highly effective when administered at a dosage of 0.5 mg/kg body weight against a broad range of economically important endoparasites and ectoparasites that infect beef and dairy cattle, including lactating dairy cows.

Mode of action studies indicate that CYDECTIN eliminates parasites by causing paralysis through interfering with neurotransmission of the gamma-aminobutyric acid (GABA)-gated or glutamate-gated chloride channels.

Composition

CYDECTIN Pour-On comes ready to use as a violet solution containing 5 mg/mL (0.5% w/v) moxidectin.

Cydectin (Pour-On for Beef and Dairy Cattle) Indications

CYDECTIN Pour-On is indicated for the treatment of healthy cattle of all ages and breeds including pregnant cows, breeding bulls and lactating dairy cows, which are parasitized by the following gastrointestinal roundworms (including inhibited larvae of Ostertagia ostertagi), lungworms, grubs, mange mites and biting and sucking lice.

Gastrointestinal Roundworms

Ostertagia ostertagi - Adults, Developing L₄, Inhibited L₄

Haemonchus placei - Adults, Developing L₄

Trichostrongylus axei - Adults, Developing L₄

Trichostrongylus colubriformis - Adults, Developing L₄

Cooperia oncophora - Adults, Developing L₄

Cooperia pectinata - Adults

Cooperia punctata - Adults, Developing L₄

Cooperia surnabada - Adults, Developing L₄

Bunostomum phlebotum - Adults

Oesophagostomum radiatum - Adults, Developing L₄

Nematodirus helvetianus - Adults, Developing L₄

Trichuris discolor - Adults, Developing L₄

Lungworms

Dictyocaulus viviparus - Adults, Developing L₄

Mange Mites

Chorioptes bovis

Psoroptes ovis (Psoroptes communis var. bovis)

Sarcoptes bovis

Biting And Sucking Lice

Linognathus vituli

Haematopinus eurysternus

Solenopotes capillatus

Damalinia (Bovicola) bovis

Grubs (migrating Larvae)

Hypoderma lineatum

Hypoderma bovis

Persistent Activity

CYDECTIN Pour-On prevents reinfection with Haemonchus placei for 14 days, Oesophagostomum radiatum, and Ostertagia ostergagi for at least 28 days and Dictycocaulus viviparus for at least 42 days following a single application at the recommended dose.

Research data, based on faecal nematode egg output (EPG counts), lice counts and controlled rainfall simulation, indicate that the application of the pour-on formulation to wet skin or application prior to a typical rain event does not affect the efficacy of the product.

Cydectin (Pour-On for Beef and Dairy Cattle) Dosage And Administration

CYDECTIN Pour-On comes ready to use. A number of different applicators have been tested with CYDECTIN Pour-On and several have proved suitable. Use of applicators is recommended when using the 2.5, 5 and 10 liter sizes and when any large group of animals is to be treated.

Dosage Table

If the animals are likely to be reinfected, a strategic parasite control program should be established.

Safety

CYDECTIN Pour-On has a very broad spectrum of activity and wide safety margin of 10X the recommended dosage of 500 µg moxidectin per kg of body weight. This safety margin is expected to be valid for cattle of most breeds, types and ages. It can be safely administered to breeding animals or replacement animals kept for breeding purposes.

CYDECTIN Pour-On does not cause irritation to the skin or hide damage when used as directed and is not harmful to the eyes of cattle.

Supplied

CYDECTIN Pour-On is supplied in 2.5 L, 5 L and 10 L plastic bottles.

Storage Conditions

CYDECTIN Pour-On should be stored between 4-25°C. Avoid freezing. Protect from light. Store bottle in box.

Cautions

1. Do not apply at the same time as any other pour-on product.

2. Apply to healthy skin. Avoid applying to mange scabs, lesions or foreign matter.

3. Dispose of any containers and any residual content safely (e.g., bury or incinerate). Bury away from water courses.

4. For external application only. Do not administer orally or parenterally to animals.

5. To avoid secondary reactions when treating Hypoderma spp. infections, consult your veterinarian on the correct timing of treatment.

Warnings

1. Treated cattle must not be slaughtered for use in food for at least 15 days after the latest treatment with this drug.

2. Do not use in milk-fed calves. Do not use in calves less than 14 weeks of age to be processed for veal.

3. Keep this and all drugs out of reach of children.

4. Avoid direct contact with skin and eyes.

NOTE TO USER - When used according to label directions, no milk withholding time is required following the application of CYDECTIN Pour-On on dairy cattle.

CYDECTIN is a registered trademark of Boehringer Ingelheim Vetmedica, Inc., used under license.

81232334, R.0

81230293

81228523

81230307

Boehringer Ingelheim (Canada) Ltd., 5180 South Service Road, Burlington, Ontario L7L 5H4

384321-00

NAC No.: 1230075.4