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Chorulon

This page contains information on Chorulon for veterinary use.
The information provided typically includes the following:
  • Chorulon Indications
  • Warnings and cautions for Chorulon
  • Direction and dosage information for Chorulon

Chorulon

This treatment applies to the following species:
Manufacturer: Intervet/Merck Animal Health

(chorionic gonadotropin)

NADA NO. 140-927; APPROVED BY FDA

Chorulon Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

CHORULON® is a freeze-dried preparation of chorionic gonadotropin (human Chorionic Gonadotropin or hCG) for intramuscular administration after reconstitution. When reconstituted with the accompanying sterile diluent, each 10 mL vial contains 10,000 I.U. chorionic gonadotropin (equivalent to 10,000 USP Units chorionic gonadotropin) and 10 mg mannitol, with mono- and disodium phosphate to adjust the pH of the solution.

Action

Chorionic gonadotropin has luteinizing hormone-like activity with little or no follicle stimulating or estrogenic activity.

Chorulon Indications

COWS: CHORULON® is indicated for intramuscular use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries.

FINFISH: CHORULON® is indicated for use as an aid in improving spawning function in male and female brood finfish.

Chorulon Dosage And Administration

To reconstitute, transfer the contents of one vial of sterile diluent into one vial of freeze-dried powder. The resulting 10 mL of CHORULON® contains 10,000 I.U. chorionic gonadotropin.

COWS: The contents of one vial (10 mL) of reconstituted CHORULON® should be administered as a single deep intramuscular injection. Dosage may be repeated in 14 days if the animal’s behavior or rectal examination of the ovaries indicates the necessity for retreatment.

FINFISH: CHORULON® should be administered via intramuscular injection just ventral to the dorsal fin for one (1) to three (3) injections. Any single injection should be administered, depending on the fish species, at a dose of 50 to 510 I.U./lb body weight (bw) for males and 67 to 1816 I.U./lb bw for females. Depending on body weight and dose administered, it may be necessary to divide the dose among two or more injection sites to avoid injecting a large volume at a single site.

Summaries of doses tested in representative fish species are contained within the following tables. The dose of CHORULON® to be used in other species of finfish may differ from those species listed in the tables, but should fall within the suggested range of 50 to 510 I.U./lb bw for males and 67 to 1816 I.U./lb bw for females.

Table 1: Tested Fish Species/Dose Combinations Found to be Effective

Nomenclature
Common Name, Genus & Species, Family

Tested Dose(s)
(I.U./lb bw/injection)

Number of Injections

Injection Interval (h)

Males

Females

yellow perch, Perca flavescens, Percidae

nt1

67-300

1

-

striped bass, Morone saxitilis, Percichthyidae

50-500

75-252

1

-

white bass, Morone chrysops, Percichthyidae

65-510

91-750

1

-

razorback sucker, Xyrauchen texanus, Catostomidae

nt

100

3

24

walleye, Stizostedion vitreum, Percidae

75-400

145-830

1-3

72

red snapper, Lutjanus campechanus, Lutjanidae

250

500

1

-

sauger, Stizostedion canadense, Percidae

500

500-1000

1

-

Chinese catfish, Clarius fuscus, Clariidae

nt

1816

1

-

Footnotes: 1, nt = not tested

Table 2: Tested Fish Species/Dose Combinations Found to be Safe

Nomenclature Common Name, Genus & Species, Family

Tested Dose(s) (I.U./lb bw/injection)

Number of Injections

Injection Interval (h)

Males

Females

white bass, Morone chrysops, Percichthyidae

750

1500

1

-

walleye, Stizostedion vitreum, Percidae

750

1500

1

-

grass carp, Ctenopharyngodon idella, Cyprinidae

2500

5000

1

-

channel catfish, Ictalurus punctatus, Ictaluridae

2500

5000

1

-

Adverse Reactions

Chorionic gonadotropin is a protein. In the unlikely event of an anaphylactic reaction, epinephrine should be administered. The administration of an antihistamine may also be indicated.

Residue Warnings

No withdrawal period is required for cows or brood finfish treated according to label directions. The total dose administered (all injections combined) should not exceed 25,000 I.U. (25 mL) per fish in fish intended for human consumption.

Storage And Handling Precautions

Store at or below room temperature, 77°F (25°C). Keep out of reach of children. Once reconstituted, CHORULON® should be used immediately. Unused solution should be disposed of properly and not stored for future use.

How Supplied

CHORULON® is supplied in cartons containing five vials of freeze-dried powder and five 10 mL vials of sterile diluent. Order Code No. CH-475-1.

FOR ANIMAL USE ONLY

Manufactured for: INTERVET INC., Millsboro, DE 19966

by: INTERVET INTERNATIONAL B.V., BOXMEER - HOLLAND

077925H 0011.240.2330

077925H 6.01

NAC No.: 10473141

MERCK ANIMAL HEALTH
Intervet Inc.

556 MORRIS AVE., SUMMIT, NJ, 07901
Customer Service:   800-521-5767
Order Desk:   800-648-2118
Technical Service (Companion Animal):   800-224-5318
Technical Service (Livestock):   800-211-3573
Fax:   908-473-5560
Website:   www.merck-animal-health-usa.com
Every effort has been made to ensure the accuracy of the Chorulon information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2014 North American Compendiums. Updated: 2014-09-05

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