AceproTabs

Mode Of Action

Acepromazine Maleate has a depressant effect on the central nervous system and therefore causes sedation, muscular relaxation and a reduction in spontaneous activity. It acts rapidly, exerting a prompt and pronounced calming effect. It is an effective preanesthetic agent and lowers the dosage requirement of general anesthetics.

Toxicology

Acute and chronic toxicity studies have shown a very low order of toxicity for Acepromazine Maleate.

A safety study using elevated dosages of ACEPROTABS demonstrated no adverse reactions even when administered at three times the upper limit of the recommended daily dosage (3.0 mg/lb body weight). The clinical observation for this high dosage was mild depression which disappeared in most dogs 24 hours after termination of dosing.

The only occurrence of adverse reaction during numerous clinical trials was a very mild respiratory distress (reverse sneeze) which was transient in nature and had no effect on the desired action of the drug.

AceproTabs Indications

As an aid in tranquilization and as a preanesthetic agent in dogs.

ACEPROTABS can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures.

Contraindications

Phenothiazines may potentiate the toxicity of organophosphates. Therefore, do not use Acepromazine Maleate to control tremors associated with organic phosphate poisoning.

Do not use in conjunction with organophosphorus vermifuges or ectoparasiticides, including flea collars.

Do not use with procaine hydrochloride.

Warning

Federal law prohibits the use of this product in animals intended for human consumption.

AceproTabs Cautions

Tranquilizers are potent central nervous system depressants, and they can cause marked sedation with suppression of the sympathetic nervous system.

Tranquilizers can produce prolonged depression or motor restlessness when given in excessive amounts or when given to sensitive animals.

Tranquilizers are additive in action to the actions of other depressants and will potentiate general anesthesia. Tranquilizers should be administered in smaller doses and with greater care during general anesthesia and also to animals exhibiting symptoms of stress, debilitation, cardiac disease, sympathetic blockade, hypovolemia or shock. Acepromazine, like other phenothiazine derivatives, is detoxified in the liver; therefore, it should be used with caution on animals with a previous history of liver dysfunction or leukopenia.

Epinephrine is contraindicated for treatment of acute hypotension produced by phenothiazine-derivative tranquilizers since further depression of blood pressure can occur.

Phenothiazines should be used with caution when followed by epidural anesthetic procedures because they may potentiate the arterial hypotensive effects of local anesthetics.

A few rare but serious occurrences of idiosyncratic reactions to Acepromazine may occur in dogs following oral or parenteral administration. These potentially serious adverse reactions include behavioral disorders in dogs such as aggression, biting/chewing, and nervousness.

AceproTabs Dosage And Administration

Dogs: 0.25-1.0 mg/lb of body weight. Dosage may be repeated as required.

How Supplied

ACEPROTABS are available in 10 & 25 mg concentrations, and are quarter scored for convenience of administration. This concentration is available in bottles of 100 and 500 tablets.

670111L-01-0402

Keep Out Of Reach Of Children

Manufactured by: Boehringer Ingelheim Vetmedica, Inc., St. Joseph, MO 64506 U.S.A.

Manufactured for: BUTLER ANIMAL HEALTH SUPPLY, DUBLIN, OHIO 43017

Nac No.

10820023