Targiniq ER

Generic Name: naloxone and oxycodone extended release tablets
Brand Names: Targiniq ER

What is Targiniq ER?

Targiniq ER contains a combination of naloxone and oxycodone. Naloxone is a special narcotic drug that reverses the effects of other narcotic medicines. Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic.

Targiniq ER is used for around-the-clock treatment of severe pain, that is not controlled by other medicines. Naloxone is included in this medicine to prevent the misuse of the narcotic ingredient.

Targiniq ER is not for use on an as-needed basis for pain that is not around-the-clock.

Important information

You should not use Targiniq ER if you have severe asthma or breathing problems, severe liver disease, or a blockage in your stomach or intestines.

Oxycodone can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Swallow the tablet whole to avoid exposure to a potentially fatal dose. Targiniq ER may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

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MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Tell your doctor if you are pregnant. Oxycodone may cause life-threatening addiction and withdrawal symptoms in a newborn.

Some drugs can raise or lower your blood levels of oxycodone, which may cause fatal overdose, or make oxycodone less effective. Tell your doctor about all other medicines you start or stop using.

Before taking this medicine

You should not use Targiniq ER if you are allergic to naloxone or oxycodone, or if you have:

  • severe asthma or breathing problems;

  • severe liver disease; or

  • a blockage in your stomach or intestines.

To make sure Targiniq ER is safe for you, tell your doctor if you have:

  • any type of breathing problem or lung disease;

  • a history of head injury, brain tumor, or seizures;

  • a history of drug abuse, alcohol addiction, or mental illness;

  • urination problems;

  • liver or kidney disease;

  • heart disease; or

  • problems with your gallbladder, pancreas, or thyroid.

FDA pregnancy category C. It is not known whether Targiniq ER will harm an unborn baby. Oxycodone may cause breathing problems, behavior changes, or life-threatening addiction and withdrawal symptoms in your newborn if you use Targiniq ER during pregnancy. Tell your doctor if you are pregnant.

See also: Pregnancy and breastfeeding warnings (in more detail)

Oxycodone can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Targiniq ER.

How should I take Targiniq ER?

Take Targiniq ER exactly as prescribed by your doctor. Follow all directions on your prescription label. Oxycodone can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take Targiniq ER in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Oxycodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away Targiniq ER is against the law.

Do not crush, chew, or break a Targiniq ER extended release tablet. Swallow it whole to avoid exposure to a potentially fatal dose.

Targiniq ER is usually taken every 12 hours. Take the medicine at the same time each day.

Do not stop using Targiniq ER suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using Targiniq ER.

Never crush or break a Targiniq ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of oxycodone and similar prescription drugs.

Store at room temperature, away from heat, moisture, and light.

Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

After you have stopped using Targiniq ER, flush any unused pills down the toilet. Disposal of medicines by flushing is recommended to reduce the danger of accidental overdose causing death. This advice applies to a very small number of medicines only. The FDA, working with the manufacturer, has determined this method to be the most appropriate route of disposal and presents the least risk to human safety.

What happens if I miss a dose?

Since Targiniq ER is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Targiniq ER overdose can be fatal, especially in a child or other person using the medicine without a prescription.

Overdose symptoms may include extreme drowsiness, weak or limp muscles, cold and clammy skin, pinpoint pupils, loss of consciousness, weak pulse, or slowed breathing (breathing may stop).

What should I avoid while taking Targiniq ER?

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with Targiniq ER. Check your food and medicine labels to be sure these products do not contain alcohol.

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how Targiniq ER will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Targiniq ER side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Targiniq ER: hives; feeling light-headed; chest pain, fast heartbeats, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • shallow breathing, slow heartbeat, cold, clammy skin;

  • seizure (convulsions);

  • confusion, severe drowsiness; or

  • a light-headed feeling, like you might pass out.

Targiniq ER is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

Common Targiniq ER side effects may include:

  • drowsiness, headache, dizziness;

  • stomach pain, nausea, constipation;

  • anxiety; or

  • sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Targiniq ER?

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Targiniq ER with a sleeping pill, muscle relaxer, other pain medicine, or medicine for anxiety, depression, or seizures.

Sometimes it is not safe to use certain medications at the same time. Some drugs can raise or lower your blood levels of oxycodone, which may cause side effects or make oxycodone less effective. Oxycodone can also affect blood levels of certain other drugs, making them less effective or increasing side effects.

TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU START OR STOP USING. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Give a list of all your medicines to any healthcare provider who treats you.

More about Targiniq ER (naloxone / oxycodone)

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Where can I get more information?

  • Your pharmacist can provide more information about Targiniq ER.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Targiniq ER only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 1.01. Revision Date: 2014-08-29, 10:25:03 AM.

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