Medication Guide App

Zelboraf Side Effects

Generic Name: vemurafenib

Note: This page contains side effects data for the generic drug vemurafenib. It is possible that some of the dosage forms included below may not apply to the brand name Zelboraf.

It is possible that some side effects of Zelboraf may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to vemurafenib: oral tablet

As well as its needed effects, vemurafenib (the active ingredient contained in Zelboraf) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking vemurafenib, check with your doctor immediately:

More common
  • Blistering, peeling, or loosening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision or other change in vision
  • chills
  • cough
  • diarrhea
  • dizziness
  • eye pain
  • fainting
  • fast or irregular heartbeat
  • fever
  • increased sensitivity of the skin to sunlight
  • itching
  • joint or muscle pain
  • lump or growth on the skin
  • pain in the ankles or knees
  • painful, red lumps under the skin, mostly on the legs
  • paralysis of the nerves
  • rapid weight gain
  • rash with flat lesions or small raised lesions on the skin
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness or other discoloration of the skin
  • redness, soreness, swelling, or itching skin
  • scaling of the skin on the hands and feet
  • sensitivity of the eye to light
  • severe sunburn
  • skin rash
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sores, welting, or blisters
  • tearing
  • tingling of the hands and feet
  • ulceration of the skin
  • unusual tiredness or weakness
  • unusual weight gain or loss

Some vemurafenib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Back or bone pain
  • burning, itching, and pain in the hairy areas, or pus at the root of the hair
  • change in taste
  • cough
  • decreased appetite
  • decreased weight
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dry skin
  • hair loss or thinning of the hair
  • headache
  • lack or loss of strength
  • loss of taste
  • muscle stiffness
  • nausea
  • pain in the arms or legs
  • rash
  • sunburn
  • vomiting

For Healthcare Professionals

Applies to vemurafenib: oral tablet

Oncologic

Very common (10% or more): Skin papilloma (up to 30%), cutaneous SCC (24%), seborrheic keratosis (up to 14%)
Common (1% to 10%): Basal cell carcinoma, oropharyngeal squamous cell carcinoma
Postmarketing reports: Progression of a preexisting-existing chronic myelomonocytic leukemia with NRAS mutation[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Atrial fibrillation, vasculitis[Ref]

Hepatic

Very common (10% or more): Hepatic laboratory abnormalities (GGT, AST, ALT, alkaline phosphatase, bilirubin) (up to 11.5%)[Ref]

Respiratory

Common (1% to 10%): Cough[Ref]

General

The most common side effects reported were arthralgia, rash, alopecia, fatigue, photosensitivity reaction, nausea, pruritus, and skin papilloma.[Ref]

Dermatologic

Very common (10% or more): Rash (up to 52%), photosensitivity (up to 49 %), alopecia (up to 45%), pruritus (up to 30%), hyperkeratosis (up to 28%), dry skin (up to 19%), erythema (up to 14%), sunburn (up to 14%)
Common (1% to 10%): Maculo-papular rash, actinic keratosis, papular rash, palmar-plantar erythrodysesthesia syndrome, keratosis pilaris, erythema nodosum, folliculitis
Uncommon (0.1% to 1%): Stevens-Johnson syndrome, toxic epidermal necrolysis
Postmarketing reports: DRESS syndrome[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 37%), diarrhea (up to 29%), vomiting (up to 26%), constipation (up to 16%)[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 21%)[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (Up to 67%), myalgia (up to 24%), pain in extremity (up to 18%)
Common (1% to 10%): Musculoskeletal pain, back pain, arthritis
Uncommon (0.1% to 1%): VIIth nerve paralysis[Ref]

Nervous system

Very common (10% or more): Headache (up to 27%), dysgeusia (up to 14%)
Common (1% to 10%): Dizziness, peripheral neuropathy[Ref]

Other

Very common (10% or more): Fatigue (up to 54%), peripheral edema (up to 23%), pyrexia (up to 19%), asthenia (up to 11%)[Ref]

Ocular

Common (1% to 10%): Uveitis
Uncommon (0.1% to 1%): Retinal vein occlusion[Ref]

References

1. "Product Information. Zelboraf (vemurafenib)." Genentech, South San Francisco, CA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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