Xofigo Side Effects

Generic Name: radium 223 dichloride

Note: This document contains side effect information about radium 223 dichloride. Some of the dosage forms listed on this page may not apply to the brand name Xofigo.

Some side effects of Xofigo may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to radium 223 dichloride: intravenous solution

Along with its needed effects, radium 223 dichloride (the active ingredient contained in Xofigo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking radium 223 dichloride:

More common
  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • chest pain
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tingling of the hands or feet
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Confusion
  • decreased frequency or amount of urine
  • dizziness
  • dry mouth
  • fainting
  • high fever
  • hoarseness
  • increase in heart rate
  • increased blood pressure
  • increased thirst
  • lightheadedness
  • loss of appetite
  • nausea
  • rapid breathing
  • sunken eyes
  • thirst
  • vomiting
  • weight gain
  • wrinkled skin

Some side effects of radium 223 dichloride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
Less common
  • Redness, pain, and swelling at the injection site

For Healthcare Professionals

Applies to radium 223 dichloride: intravenous solution

General

The most common side effects (incidence of 10% or greater) were nausea, diarrhea, vomiting, and peripheral edema.

The most common hematologic laboratory abnormalities (incidence of 10% or greater) were anemia, lymphocytopenia, leukopenia, thrombocytopenia, and neutropenia.

Hematologic

Very common (10% or more): Anemia (93%), lymphocytopenia (72%), leukopenia (35%), thrombocytopenia (31%), neutropenia (18%)
Common (1% to 10%): Pancytopenia (2%)

Gastrointestinal

Very common (10% or more): Nausea (36%), diarrhea (25%), vomiting (19%)

Local

Common (1% to 10%): Erythema, pain, and edema at the injection site

Other

Very common (10% or more): Peripheral edema (13%)
Common (1% to 10%): Dehydration (3%)

Renal

Common (1% to 10%): Renal failure and impairment (3%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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