Vitamin B6 Side Effects

Generic name: pyridoxine

Note: This document contains side effect information about pyridoxine. Some of the dosage forms listed on this page may not apply to the brand name Vitamin B6.

Some side effects of Vitamin B6 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to pyridoxine: injectable solution, oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking pyridoxine (the active ingredient contained in Vitamin B6) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• decreased sensation to touch, temperature, and vibration;

• loss of balance or coordination;

• numbness in your feet or around your mouth;

• clumsiness in your hands; or

• feeling tired.

Less serious side effects of pyridoxine may include:

• nausea;

• headache;

• drowsiness; or

• mild numbness or tingling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to pyridoxine: compounding powder, injectable solution, oral tablet

Nervous system

The profound sensory loss following treatment with high doses of parenteral pyridoxine (the active ingredient contained in Vitamin B6) may not be reversible.

Nervous system side effects have included sensory neuropathy with axonal degeneration. The adverse neurologic side effects have been reported following a single large dose (10 g) administered intravenously. It may rarely occur following chronic administration of lower doses. Peripheral sensory neuropathy has also been reported.

Hypersensitivity

Hypersensitivity side effects have been reported rarely.

Dermatologic

Dermatologic side effects have included allergic contact dermatitis. Photosensitivity has been confirmed in a female patient taking pyridoxine (the active ingredient contained in Vitamin B6) 100 mg orally daily.

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