Vistaril Side Effects
Generic Name: hydroxyzine
Note: This page contains side effects data for the generic drug hydroxyzine. It is possible that some of the dosage forms included below may not apply to the brand name Vistaril.
It is possible that some side effects of Vistaril may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to hydroxyzine: oral capsules, oral suspension or solution, parenteral injection
Side effects include:
Drowsiness, dry mouth.
For Healthcare Professionals
Applies to hydroxyzine: compounding powder, intramuscular solution, oral capsule, oral suspension, oral syrup, oral tablet
Nervous system side effects have included moderate to slight drowsiness. This effect is usually transitory and may disappear with continued therapy or upon discontinuation of the agent. Headache, fatigue, depression, insomnia, sedation, and nervousness have also been reported with hydroxyzine (the active ingredient contained in Vistaril) With higher than recommended doses of hydroxyzine, involuntary motor activity such as tremor and convulsions have been reported in rare instances.[Ref]
Gastrointestinal side effects have included dry mouth (most common side effect), nausea, diarrhea, abdominal pain, and increases in weight and appetite.[Ref]
Respiratory side effects have included the thickening of bronchial secretions. Rare occurrences of pharyngitis, bronchospasm, and epistaxis have also been reported.[Ref]
Cardiovascular side effects have included palpitations, hypotension, and edema.[Ref]
Dermatologic side effects have included angioedema, photosensitivity, and rash.[Ref]
Genitourinary side effects have included rare cases of urinary retention and prolonged penile erections.[Ref]
Ocular side effects have included blurred vision.[Ref]
1. Maddox DE, Reed CE "Clinical pharmacodynamics of antihistamines." Ann Allergy 59 (1987): 43-8
2. Simons FE, Watson WT, Chen XY, Minuk GY, Simons KJ "The pharmacokinetics and pharmacodynamics of hydroxyzine in patients with primary biliary cirrhosis." J Clin Pharmacol 29 (1989): 809-15
3. Simons FE, Simons KJ, Frith EM "The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine." J Allergy Clin Immunol 73 (1984): 69-75
4. "Product Information. Vistaril (hydroxyzine)." Pfizer US Pharmaceuticals, New York, NY.
5. Michel M, Dompmartin A, Louvet S, Szczurko C, Castel B, Leroy D "Skin reactions to hydroxyzine." Contact Dermatitis 36 (1997): 147-9
6. Thavundayil JX, Hambalek R, Kin NMKNY, Krishnan B, Lal S "Prolonged penile erections induced by hydroxyzine: possible mechanism of action." Neuropsychobiology 30 (1994): 4-6
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