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Vibativ Side Effects

Generic Name: telavancin

Note: This page contains side effects data for the generic drug telavancin. It is possible that some of the dosage forms included below may not apply to the brand name Vibativ.

It is possible that some side effects of Vibativ may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to telavancin: intravenous powder for solution

As well as its needed effects, telavancin (the active ingredient contained in Vibativ) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking telavancin, check with your doctor or nurse immediately:

Less common
  • Blood in the urine
  • change in the frequency of urination or amount of urine
  • difficulty with breathing
  • drowsiness
  • increased thirst
  • loss of appetite
  • nausea or vomiting
  • swelling of the feet or lower legs
  • weakness
Incidence not known
  • Abdominal or stomach tenderness
  • chills or fever
  • cough
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness, especially when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • hives or itching of the skin
  • nausea or vomiting
  • pain, redness, or soreness at the injection site
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash or redness of the face, base of the neck, upper body, back, and arms
  • severe abdominal or stomach cramps and pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

Some telavancin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Bad, unusual or unpleasant (after) taste
  • change in taste
  • diarrhea
  • foamy urine
Less common
  • Decreased appetite
  • dry, red, hot, or irritated skin
  • feeling unusually cold
  • shivering

For Healthcare Professionals

Applies to telavancin: intravenous powder for injection


Very common (10% or more): All-cause mortality (up to 44%)
Common (1% to 10%): Fungal infection, fatigue, chills
Uncommon (0.1% to 1%): Septic shock, multi-organ failure, tinnitus, asthenia, malaise, non-cardiac chest pain, peripheral edema, pain, pyrexia, infusion site reactions including Red Man syndrome
Rare (less than 0.1%): Deafness[Ref]


Very common (10% or more): Increased serum creatinine to 1.5 times baseline (up to 16%), renal impairment/renal insufficiency/renal failure (up to 10%)
Common (1% to 10%): Acute renal failure, increased blood creatinine
Uncommon (0.1% to 1%): Increased blood urea[Ref]


Uncommon (0.1% to 1%): Anemia, leukopenia, thrombocythemia, thrombocytopenia, increased eosinophil count, increased neutrophil count, increased INR


Common (1% to 10%): QTc prolongation
Uncommon (0.1% to 1%): Angina pectoris, atrial fibrillation, bradycardia, congestive cardiac failure, prolonged electrocardiogram QT corrected interval, palpitations, sinus tachycardia, supraventricular extrasystoles, ventricular extrasystoles, flushing, hypertension, hypotension, phlebitis[Ref]


Very common (10% or more): Nausea (up to 27%), vomiting (up to 14%)
Common (1% to 10%): Diarrhea, constipation
Uncommon (0.1% to 1%): Clostridium colitis, abdominal pain, dry mouth, dyspepsia, flatulence, oral hypoesthesia[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions
Postmarketing reports: Anaphylaxis[Ref]

Nervous system

Very common (10% or more): Metallic/soapy taste disturbance (up to 33%), dysgeusia (more than 10%)
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Ageusia, migraine, paraesthesia, parosmia, somnolence, tremor[Ref]


Very common (10% or more): Foamy urine (up to 13%)
Uncommon (0.1% to 1%): Urinary tract infection, dysuria, hematuria, microalbuminuria, oliguria, pollakiuria, abnormal urine odor


Common (1% to 10%): Increased ALT, increased AST
Uncommon (0.1% to 1%): Hepatitis


Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Erythema, face edema, hyperhidrosis, urticaria[Ref]


Common (1% to 10%): Decreased appetite
Uncommon (0.1% to 1%): Hyperglycemia, hyperkalemia, hypoglycemia, hypokalemia, hypomagnesemia[Ref]


Common (1% to 10%): Rigors
Uncommon (0.1% to 1%): Arthralgia, back pain, muscle cramp, myalgia


Uncommon (0.1% to 1%): Eye irritation, blurred vision


Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Agitation, anxiety, confusional state, depression


Uncommon (0.1% to 1%): Dyspnea, hiccups, nasal congestion, pharyngolaryngeal pain


1. "Product Information. Vibativ (telavancin)." Theravance Inc, South San Francisco, CA.

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