Valstar Side Effects

Generic Name: valrubicin

Note: This document contains side effect information about valrubicin. Some of the dosage forms listed on this page may not apply to the brand name Valstar.

Some side effects of Valstar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to valrubicin: intravesical solution

Along with its needed effects, valrubicin (the active ingredient contained in Valstar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of valrubicin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Blood in urine
  • loss of bladder control
  • painful or difficult urination
  • red color in urine
  • strong urge to urinate
  • unusually frequent urination
Less common
  • Increased urination at night
  • local burning sensation
  • Frequent urge to defecate
  • itching
  • loss of sense of taste

For Healthcare Professionals

Applies to valrubicin: irrigation solution


Local adverse reactions associated with valrubicin (the active ingredient contained in Valstar) usually occurred during or shortly after instillate and resolve within one to seven days after the instillation is removed from the bladder.

Local side effects including any local bladder symptom (88%) and procedure related burning symptoms (5%) have been reported.


Genitourinary side effects including urinary frequency (61%), urinary urgency (57%), dysuria (56%), bladder spasm (31%), hematuria (29%), bladder pain (28%), urinary incontinence (22%), urinary tract infection (15%), cystitis (15%), nocturia (7%), urinary retention (4%), microscopic hematuria (3%), urethral pain (3%), pelvic pain (1%), and gross hematuria (1%) have been reported.


General side effects including abdominal pain (5%), asthenia (4%), headache (4%), malaise (4%), back pain (3%), chest pain (3%), and fever (2%) have been reported.


Gastrointestinal side effects including nausea (5%), diarrhea (3%), vomiting (2%), and flatulence (1%) have been reported.

Nervous system

Nervous system side effects including dizziness (3%) have been reported.


Dermatologic side effects including rash (3%) have been reported.


Cardiovascular side effects including vasodilation (2%) have been reported.


Hematologic side effects including anemia (2%) have been reported.


Metabolic side effects including hyperglycemia (1%) and peripheral edema (1%) have been reported.


Musculoskeletal side effects including myalgia (1%) have been reported.


Respiratory side effects including pneumonia (1%) have been reported.

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