Urofollitropin Side Effects

It is possible that some side effects of urofollitropin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to urofollitropin: powder for solution

As well as its needed effects, urofollitropin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking urofollitropin, check with your doctor immediately:

More common
  • Abdominal or pelvic pain
  • bloating (mild)
Less common or rare
  • Abdominal or stomach pain (severe)
  • bloating (moderate to severe)
  • chest pain or trouble breathing
  • decreased amount of urine
  • feeling of indigestion
  • headache, sudden and severe
  • nausea, vomiting, or diarrhea (continuing or severe)
  • pelvic pain (severe)
  • shortness of breath or wheezing
  • skin rash or hives
  • swelling of the arms or lower legs
  • weight gain (rapid)

Some urofollitropin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare
  • Breast tenderness
  • diarrhea (mild)
  • headache
  • hot flashes
  • nausea
  • redness, pain, or swelling at the injection site
  • vomiting

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

  • Abdominal or stomach pain (severe)
  • bloating (moderate to severe)
  • decreased amount of urine
  • feeling of indigestion
  • nausea, vomiting, or diarrhea (continuing or severe)
  • pelvic pain (severe)
  • shortness of breath
  • swelling of the lower legs
  • weight gain (rapid)

For Healthcare Professionals

Applies to urofollitropin: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection

General

The most common adverse events were multi-fetal gestation and birth, abdominal cramps, headache, and ovarian hyperstimulation syndrome (OHSS).[Ref]

Genitourinary

Very common (10% or more): Multi-fetal gestation and birth (up to 66.7%), ovarian hyperstimulation syndrome (OHSS) (11.4%)
Common (1% to 10%): Hot flashes, vaginal hemorrhage, ovarian disorder (pain, cyst), urinary tract infection, cervix disorder, post retrieval pain, uterine spasms, vaginal spotting, breast tenderness, vaginal discharge, infection fungal
Frequency not reported: Abnormal ovarian enlargement
Postmarketing reports: Ovarian enlargement, pelvic pain, hot flushes[Ref]

Cardiovascular

Common (1% to 10%): Hypertension[Ref]

Dermatologic

Common (1% to 10%): Acne, exfoliative dermatitis, rash[Ref]

Gastrointestinal

Very common (10% or more): Abdominal cramps (14%)
Common (1% to 10%): Nausea, enlarged abdomen, abdominal pain, vomiting, diarrhea, constipation[Ref]

Local

Common (1% to 10%): Injection site reactions[Ref]

Metabolic

Common (1% to 10%): Weight gain, dehydration

Musculoskeletal

Common (1% to 10%): Neck pain
Postmarketing reports: Muscle spasm

Nervous system

Very common (10% or more): Headache (12.7%)

Other

Common (1% to 10%): Pain, fever, accidental injury[Ref]

Psychiatric

Common (1% to 10%): Emotional lability, depression

Respiratory

Common (1% to 10%): Respiratory disorder, sinusitis
Postmarketing reports: Nasopharyngitis[Ref]

References

1. "Product Information. Fertinex Injection (urofollitropin)." Serono Laboratories Inc, Norwell, MA.

2. "Product Information. Bravelle (urofollitropin)." Ferring Pharmaceuticals Inc, Tarrytown, NY.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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